Zhiwei Li, Jiwei Ren, Xin Sui, Nan Yang, Sijia Li, Le Qi, Sining Li, Yixin Fan, Zhihui Liu
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引用次数: 0
摘要
细菌感染是伤口愈合过程中最常见的并发症,因此迫切需要开发创新的抗菌技术和治疗方法,以应对细菌感染带来的日益严重的威胁。黑磷纳米片(BPNS)作为一种前景广阔的二维纳米材料,已被用于治疗受感染的伤口。然而,BP 有限的稳定性限制了它的应用。在本研究中,我们通过在 BP 表面锚定镓离子(Ga3+),增强了 BP 的稳定性和抗菌性能,从而创建了一种新型抗菌平台。这种改性降低了 BP 的电子密度,并通过协同效应增强了其抗菌能力。在近红外(NIR)照射下,BP/Ga3+组合通过光热疗法(PTT)和光动力疗法(PDT)发挥抗菌作用,同时还释放出Ga3+。Ga3+ 采用 "特洛伊木马策略 "破坏铁的新陈代谢,大大提高了复合物的抗菌功效。这种创新材料是抗生素的可行替代品,在治疗感染伤口和帮助皮肤重建方面大有可为。
A win-win platform: Stabilized black phosphorous nanosheets loading gallium ions for enhancing the healing of bacterial-infected wounds through synergistic antibacterial approaches
Bacterial infection is the most common complication in wound healing, highlighting an urgent need for the development of innovative antibacterial technologies and treatments to address the growing threats posed by bacterial infections. Black phosphorus nanosheets (BPNSs), as a promising two-dimensional nanomaterial, have been utilized in treating infected wounds. However, BP's limited stability restricts its application. In this study, we enhance BP's stability and its antibacterial properties by anchoring gallium ions (Ga3+) onto BP's surface, creating a novel antibacterial platform. This modification reduces BP's electron density and enhances its antibacterial capabilities through a synergistic effect. Under near-infrared (NIR) irradiation, the BP/Ga3+ combination exerts antibacterial effects via photothermal therapy (PTT) and photodynamic therapy (PDT), while also releasing Ga3+. The Ga3+ employ a ‘Trojan horse strategy’ to disrupt iron metabolism, significantly boosting the antibacterial efficacy of the complex. This innovative material offers a viable alternative to antibiotics and holds significant promise for treating infected wounds and aiding skin reconstruction.
期刊介绍:
The Editors welcome papers on all aspects of prevention and treatment of wounds and associated conditions in the fields of surgery, dermatology, oncology, nursing, radiotherapy, physical therapy, occupational therapy and podiatry. The Journal accepts papers in the following categories:
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The Editors are supported by a board of international experts and a panel of reviewers across a range of disciplines and specialties which ensures only the most current and relevant research is published.