口咽混合性神经内分泌-非神经内分泌肿瘤（MiNEN）：病例报告与文献综述

IF 3.2 Q2 PATHOLOGY Head & Neck Pathology Pub Date : 2024-06-19 DOI:10.1007/s12105-024-01660-3

Leen AlQudah, Trevor Hackman, Amy Brownlee

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引用次数: 0

摘要

头颈部神经内分泌-非神经内分泌混合瘤（MiNEN）是一种异常罕见的双相肿瘤，发病机制不清，临床表现具有侵袭性。这是首例报道的口咽部 MiNEN 病例，其中的非神经内分泌成分是人乳头瘤病毒相关腺癌。该肿瘤发生在一名有长期吸烟史的 56 岁男性身上，由腺癌和小细胞神经内分泌癌混合组成。P16免疫组化染色和HPV16/18原位杂交在这两种成分中均有强烈的弥漫表达。

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Oropharyngeal Mixed Neuroendocrine-Nonneuroendocrine Neoplasm (MiNEN): A Case Report and Literature Review.

Mixed neuroendocrine-nonneuroendocrine (MiNEN) neoplasms in the head and neck are exceptionally rare biphasic tumors with unclear pathogenesis and an aggressive clinical behavior. This is the first reported case of an oropharyngeal MiNEN with the nonneuroendocrine component being an HPV-associated adenocarcinoma. The tumor arose in a 56 year-old male with history of long-term cigarette smoking and was composed of an adenocarcinoma intermixed with a small cell neuroendocrine carcinoma. P16 immunohistochemical stain and HPV16/18 in-situ hybridization were strongly and diffusely expressed in both components.

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来源期刊

Head & Neck Pathology PATHOLOGY-

CiteScore

5.70

自引率

9.50%

发文量

期刊介绍： Head & Neck Pathology presents scholarly papers, reviews and symposia that cover the spectrum of human surgical pathology within the anatomic zones of the oral cavity, sinonasal tract, larynx, hypopharynx, salivary gland, ear and temporal bone, and neck. The journal publishes rapid developments in new diagnostic criteria, intraoperative consultation, immunohistochemical studies, molecular techniques, genetic analyses, diagnostic aids, experimental pathology, cytology, radiographic imaging, and application of uniform terminology to allow practitioners to continue to maintain and expand their knowledge in the subspecialty of head and neck pathology. Coverage of practical application to daily clinical practice is supported with proceedings and symposia from international societies and academies devoted to this field. Single-blind peer review The journal follows a single-blind review procedure, where the reviewers are aware of the names and affiliations of the authors, but the reviewer reports provided to authors are anonymous. Single-blind peer review is the traditional model of peer review that many reviewers are comfortable with, and it facilitates a dispassionate critique of a manuscript.