Sweeta Akbari*, Mart Kroon, Vijay Singh Parihar, Janne T. Koivisto, Markus Hannula, Minna Kellomäki and Jari Hyttinen,
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Synthesis and Characterization of PolyHIPE-Gellan Gum Material with Tunable Macroporosity for Tissue Engineering Applications
Polymerized high internal phase emulsions (polyHIPEs) were combined with gellan gum (GG) in an innovative approach. Four GG concentrations in polyHIPEs (P-GG 0%, P-GG 0.1%, P-GG 0.5%, and P-GG 1%) were explored for their impact on polyHIPE materials. The resulting macroporous polyHIPE-GG (P-GG) scaffolds exhibited up to 95% porosity and remarkable interconnectivity. Elevating GG concentration correlated with larger pore sizes, increased hydrophilicity, and degradability. Scanning electron microscopy (SEM) and X-ray microcomputed tomography provided insights into the structural influence of GG on polyHIPE materials. Pore sizes ranged from 32 to 1036 μm. In vitro Live/Dead assay confirmed the cytocompatibility of these scaffolds with human fibroblast cells, showcasing their potential for mimicking cartilage and bone tissue structures, promoting cell activities, nutrient exchange, supporting various cell lines, and facilitating vascularization.
期刊介绍：
Macromolecules publishes original, fundamental, and impactful research on all aspects of polymer science. Topics of interest include synthesis (e.g., controlled polymerizations, polymerization catalysis, post polymerization modification, new monomer structures and polymer architectures, and polymerization mechanisms/kinetics analysis); phase behavior, thermodynamics, dynamic, and ordering/disordering phenomena (e.g., self-assembly, gelation, crystallization, solution/melt/solid-state characteristics); structure and properties (e.g., mechanical and rheological properties, surface/interfacial characteristics, electronic and transport properties); new state of the art characterization (e.g., spectroscopy, scattering, microscopy, rheology), simulation (e.g., Monte Carlo, molecular dynamics, multi-scale/coarse-grained modeling), and theoretical methods. Renewable/sustainable polymers, polymer networks, responsive polymers, electro-, magneto- and opto-active macromolecules, inorganic polymers, charge-transporting polymers (ion-containing, semiconducting, and conducting), nanostructured polymers, and polymer composites are also of interest. Typical papers published in Macromolecules showcase important and innovative concepts, experimental methods/observations, and theoretical/computational approaches that demonstrate a fundamental advance in the understanding of polymers.
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