白细胞介素-10缺乏会诱发胸部血管周围脂肪组织变白和血管重塑。

IF 2.9 4区生物学 Q3 CELL BIOLOGY Journal of Molecular Histology Pub Date : 2024-06-19 DOI:10.1007/s10735-024-10202-8

Raiany A. de Freitas, Rinaldo R. dos Passos Jr, Fernanda C. A. dos Santos, Alecsander F. M. Bressan, Fernando S. Carneiro, Victor V. Lima, Fernanda R. C. Giachini

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引用次数: 0

摘要

血管周围脂肪组织（PVAT）是血管周围的脂肪层，具有局部调节作用。白细胞介素-10（IL-10）已被证明能调节血管组织。本研究旨在确定 IL-10 在血管重塑和 PVAT 表型中的内源性作用。研究使用了对照组（C57BL/6J）和IL-10基因敲除（IL-10-/-）雄性小鼠的胸主动脉切片。对主动脉/PVAT形态测量以及弹性蛋白、胶原蛋白和网状纤维素沉积进行了分析。通过 Western 印迹法检测组织解偶联蛋白 1（UCP1）。内源性 IL-10 的缺失减少了 PVAT 总面积（p = 0.0310）和管壁/管腔比率（p = 0.0024），而增加了血管面积和厚度（p -/-，但在偏振光下，发现胶原蛋白-I 减少（p = 0.0075），胶原蛋白-III 增加（p = 0.0055），同时弹性纤维沉积减少（p = 0.0282），网状纤维沉积增加（p -/-，p -/-为白色样脂肪细胞表型。内源性IL-10可防止血管重塑并有利于棕色样脂肪细胞表型，这表明IL-10在PVAT可塑性中起着调节作用。

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Interleukin-10 deficiency induces thoracic perivascular adipose tissue whitening and vascular remodeling

Absence of endogenous IL-10 reduces total thoracic PVAT.

Brown adipose PVAT whitening is observed in thoracic aortas from IL-10^-/- mice.

Thoracic PVAT adipocyte size is augmented and UCP1 expression is reduced in IL-10^-/- mice.

Thoracic aortas from IL-10^-/- mice display augmented thickness and vascular remodeling.

Remodeling is characterized by augmented collagen-III and reduced elastic fibers.

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来源期刊

Journal of Molecular Histology 生物-细胞生物学

CiteScore

5.90

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： The Journal of Molecular Histology publishes results of original research on the localization and expression of molecules in animal cells, tissues and organs. Coverage includes studies describing novel cellular or ultrastructural distributions of molecules which provide insight into biochemical or physiological function, development, histologic structure and disease processes. Major research themes of particular interest include: - Cell-Cell and Cell-Matrix Interactions; - Connective Tissues; - Development and Disease; - Neuroscience. Please note that the Journal of Molecular Histology does not consider manuscripts dealing with the application of immunological or other probes on non-standard laboratory animal models unless the results are clearly of significant and general biological importance. The Journal of Molecular Histology publishes full-length original research papers, review articles, short communications and letters to the editors. All manuscripts are typically reviewed by two independent referees. The Journal of Molecular Histology is a continuation of The Histochemical Journal.