N-乙酰半胱氨酸作为一种潜在的安全辅助剂,用于治疗甲基吡啶磷中毒引起的神经中毒。

IF 2.7 4区 医学 Q2 PHARMACOLOGY & PHARMACY Basic & Clinical Pharmacology & Toxicology Pub Date : 2024-06-19 DOI:10.1111/bcpt.14044
Adamczuk Piotr, Jamka Konrad, Bojar Hubert, Łukawski Krzysztof, Raszewski Grzegorz
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引用次数: 0

摘要

外源性、公认的抗氧化剂 N-乙酰半胱氨酸可减少或防止杀虫剂的有害影响。在这项研究中,我们利用每天单剂量给药 N-乙酰半胱氨酸的小鼠模型,研究了这种辅助剂对阿托品和/或奥比多肟治疗的影响,以及嘧啶磷-甲基诱导毒性中氧化应激反应的影响。我们发现,N-乙酰半胱氨酸能显著降低甲基嘧啶磷产生的氧化应激。在包括甲基嘧啶磷在内的有机磷杀虫剂中毒中常规使用的阿托品和/或奥比多肟疗法对 N-乙酰半胱氨酸的抗氧化特性没有影响。N-乙酰半胱氨酸提供的辅助治疗填补了治疗空白,并可充分发挥其抗击甲基嘧啶磷引起的毒性的潜力。
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N-acetylcysteine as a potentially safe adjuvant in the treatment of neurotoxicity due to pirimiphos-methyl poisoning

Exogenous, well-established antioxidant N-acetylcysteine can reduce or prevent the deleterious effects of pesticides. In this study, utilizing a mouse model of daily single dose of N-acetylcysteine administration, we investigated the impact of this adjuvant on the treatment with atropine and/or obidoxime as well as oxidative stress response in pyrimiphos-methyl-induced toxicity. We found that N-acetylcysteine significantly reduces the oxidative stress generated by pyrimiphos-methyl. The therapy consisting of atropine and/or obidoxime routinely used in organophosphorous insecticide poisonings, including pyrimiphos-methyl, had no effect on the antioxidant properties of N-acetylcysteine. Adjunctive treatment offered by N-acetylcysteine fills therapeutic gap and may provide the full potential against pyrimiphos-methyl-induced toxicity.

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来源期刊
CiteScore
5.60
自引率
6.50%
发文量
126
审稿时长
1 months
期刊介绍: Basic & Clinical Pharmacology and Toxicology is an independent journal, publishing original scientific research in all fields of toxicology, basic and clinical pharmacology. This includes experimental animal pharmacology and toxicology and molecular (-genetic), biochemical and cellular pharmacology and toxicology. It also includes all aspects of clinical pharmacology: pharmacokinetics, pharmacodynamics, therapeutic drug monitoring, drug/drug interactions, pharmacogenetics/-genomics, pharmacoepidemiology, pharmacovigilance, pharmacoeconomics, randomized controlled clinical trials and rational pharmacotherapy. For all compounds used in the studies, the chemical constitution and composition should be known, also for natural compounds.
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