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引用次数: 0
摘要
肥胖者体内过多的脂肪沉积会诱发代谢性疾病，如 2 型糖尿病（T2DM）、心血管疾病和非酒精性脂肪肝（NAFLD）。脂肪组织不仅是能量储存的主要形式，也是一个内分泌器官，不仅能分泌脂肪细胞因子，还能释放出许多细胞外小泡（EVs），在调节全身代谢中发挥作用。外泌体是EVs的一种亚型，越来越多的证据表明，脂肪组织外泌体（AT Exos）通过旁分泌或内分泌机制转移到目标细胞或组织，从而介导脂肪组织与多个器官之间的串联。然而，脂肪组织外泌体在与代谢器官串联中的作用仍有待全面阐明。在这篇综述中，我们总结了 AT Exos 在调节代谢紊乱中的作用的最新研究进展。此外，我们还讨论了AT Exos作为生物标记物在代谢性疾病中的潜在作用及其临床应用。
The Role of Adipose Tissue-derived Exosomes in Chronic Metabolic Disorders.
Excessive fat deposition in obese subjects promotes the occurrence of metabolic diseases, such as type 2 diabetes mellitus (T2DM), cardiovascular diseases, and non-alcoholic fatty liver disease (NAFLD). Adipose tissue is not only the main form of energy storage but also an endocrine organ that not only secretes adipocytokines but also releases many extracellular vesicles (EVs) that play a role in the regulation of whole-body metabolism. Exosomes are a subtype of EVs, and accumulating evidence indicates that adipose tissue exosomes (AT Exos) mediate crosstalk between adipose tissue and multiple organs by being transferred to targeted cells or tissues through paracrine or endocrine mechanisms. However, the roles of AT Exos in crosstalk with metabolic organs remain to be fully elucidated. In this review, we summarize the latest research progress on the role of AT Exos in the regulation of metabolic disorders. Moreover, we discuss the potential role of AT Exos as biomarkers in metabolic diseases and their clinical application.
期刊介绍：
Current Medical Science provides a forum for peer-reviewed papers in the medical sciences, to promote academic exchange between Chinese researchers and doctors and their foreign counterparts. The journal covers the subjects of biomedicine such as physiology, biochemistry, molecular biology, pharmacology, pathology and pathophysiology, etc., and clinical research, such as surgery, internal medicine, obstetrics and gynecology, pediatrics and otorhinolaryngology etc. The articles appearing in Current Medical Science are mainly in English, with a very small number of its papers in German, to pay tribute to its German founder. This journal is the only medical periodical in Western languages sponsored by an educational institution located in the central part of China.
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