霍奇金淋巴瘤的现代放射治疗。

IF 5 3区 医学 Q1 HEMATOLOGY Seminars in hematology Pub Date : 2024-05-31 DOI:10.1053/j.seminhematol.2024.05.006
Omran Saifi, Bradford S Hoppe
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引用次数: 0

摘要

放射治疗在霍奇金淋巴瘤的治疗中起着举足轻重的作用,尤其是在联合模式治疗中。它是治疗早期疾病和缓解晚期局部复发高风险病例的基石。近几十年来,放射治疗取得了长足的进步,特别是随着诊断成像技术的改进,放射野的大小和剂量都有所减少。这一进步显著降低了毒性,同时保持了疗效。这篇综合综述广泛评估了霍奇金淋巴瘤放射治疗的适应症和进展,主要侧重于提高疗效,同时最大限度地减少放射相关毒性。研究详细探讨了霍奇金淋巴瘤治疗中采用的各种放射领域、技术和给药模式,包括调强放射治疗(IMRT)、体调弧治疗(VMAT)和质子治疗。它深入探讨了最佳剂量选择和治疗计划策略的复杂性,旨在实现最大程度的疾病控制,同时将长期副作用的风险降至最低。
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Contemporary radiation therapy use in Hodgkin lymphoma.

Radiation therapy assumes a pivotal role in Hodgkin lymphoma management, especially within combined modality therapy. It serves as a cornerstone in early-stage disease and in mitigating high-risk instances of local relapse in advanced stages. Over recent decades, radiation therapy has undergone significant advancements, notably alongside diagnostic imaging improvements, facilitating the reduction of radiation field size and dosage. This progress has notably led to minimized toxicity while upholding treatment efficacy. This comprehensive review extensively evaluates the indications and advancements in radiation therapy for Hodgkin lymphoma, with a primary focus on enhancing treatment efficacy while minimizing radiation-related toxicities. The exploration encompasses a detailed examination of various radiation fields, techniques and delivery modalities employed in Hodgkin lymphoma treatment, including intensity-modulated radiation therapy (IMRT), volumetric modulated arc therapy (VMAT), and proton therapy. It delves into the intricacies of optimal dose selection and treatment planning strategies aimed at achieving maximal disease control while concurrently minimizing the risk of long-term side effects.

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来源期刊
Seminars in hematology
Seminars in hematology 医学-血液学
CiteScore
6.20
自引率
2.80%
发文量
30
审稿时长
35 days
期刊介绍: Seminars in Hematology aims to present subjects of current importance in clinical hematology, including related areas of oncology, hematopathology, and blood banking. The journal''s unique issue structure allows for a multi-faceted overview of a single topic via a curated selection of review articles, while also offering a variety of articles that present dynamic and front-line material immediately influencing the field. Seminars in Hematology is devoted to making the important and current work accessible, comprehensible, and valuable to the practicing physician, young investigator, clinical practitioners, and internists/paediatricians with strong interests in blood diseases. Seminars in Hematology publishes original research, reviews, short communications and mini- reviews.
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