两种旧的免疫抑制剂甲氨蝶呤和硫唑嘌呤治疗扁平苔藓的临床疗效:随机临床试验

IF 3.7 4区 医学 Q1 DERMATOLOGY Dermatologic Therapy Pub Date : 2024-06-19 DOI:10.1155/2024/5556945
Mina Saber, Parisa Hajheidari, Farahnaz Fatemi Naeini, Fatemeh Mohaghegh
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引用次数: 0

摘要

背景。扁平苔癣是卡他性脱发的主要病因,其治疗对皮肤科医生来说极具挑战性。这是一种细胞介导的自身免疫性疾病,活化的 T 淋巴细胞会攻击毛囊。研究目的比较甲氨蝶呤和硫唑嘌呤这两种影响淋巴细胞功能的药物在治疗白发性脱发症中的疗效和安全性。方法32 名 LPP 患者被随机分配接受每周 15 毫克的甲氨蝶呤或每公斤 2 毫克的硫唑嘌呤治疗,为期 6 个月。在治疗 2、4 和 6 个月后,使用扁平苔藓活动指数 (LPPAI)、毛囊镜检查和摄影来评估疗效。结果显示甲氨蝶呤组和硫唑嘌呤组的 LPPAI(P <0.001)和毛囊周围鳞屑(P <0.01)均有显著改善。不过,两组在研究期间没有明显差异。硫唑嘌呤组明显改善了毛囊周围红斑(P = 0.002),但与甲氨蝶呤组(P = 0.69)无明显差异。照片评估显示,两组中均有 75% 以上的患者病情有所改善,两组之间无明显差异。结论甲氨蝶呤和硫唑嘌呤这两种抗淋巴细胞药物对治疗 LPP 同样有效,且耐受性良好。本试验注册号为 IRCT20191006045005N2。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Clinical Effectiveness of Two Old Immunosuppressant Drugs, Methotrexate and Azathioprine, in the Treatment of Lichen Planopilaris: A Randomized Clinical Trial

Background. Lichen planopilaris is the leading cause of cicatricial alopecia, and its management is challenging for dermatologists. It is a cell-mediated autoimmune disorder in which activated T-lymphocytes attack hair follicles. Aim. To compare the efficacy and safety of methotrexate versus azathioprine, two medications that affect lymphocyte function, in treating LPP. Methods. 32 LPP patients were randomly assigned to receive either 15 mg/week methotrexate or 2 mg/kg azathioprine for six months. Treatment efficacy was evaluated using the Lichen Planopilaris Activity Index (LPPAI), trichoscopy, and photography after 2, 4, and 6 months of treatment. Results. Both methotrexate and azathioprine groups showed significant improvements in LPPAI (P < 0.001) and perifollicular scaling on trichoscopy (P < 0.01). However, the two groups had no significant difference during the study. The azathioprine group significantly improved perifollicular erythema on trichoscopy (P = 0.002), but this was not significantly different from the methotrexate group (P = 0.69). Photographic assessment showed that more than 75% of patients in both groups improved without significant differences between the two groups. Conclusion. Methotrexate and azathioprine are two antilymphocyte medications which are both equally effective and well-tolerated for managing LPP. This trial is registered with IRCT20191006045005N2.

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来源期刊
Dermatologic Therapy
Dermatologic Therapy 医学-皮肤病学
CiteScore
7.00
自引率
8.30%
发文量
711
审稿时长
3 months
期刊介绍: Dermatologic Therapy has been created to fill an important void in the dermatologic literature: the lack of a readily available source of up-to-date information on the treatment of specific cutaneous diseases and the practical application of specific treatment modalities. Each issue of the journal consists of a series of scholarly review articles written by leaders in dermatology in which they describe, in very specific terms, how they treat particular cutaneous diseases and how they use specific therapeutic agents. The information contained in each issue is so practical and detailed that the reader should be able to directly apply various treatment approaches to daily clinical situations. Because of the specific and practical nature of this publication, Dermatologic Therapy not only serves as a readily available resource for the day-to-day treatment of patients, but also as an evolving therapeutic textbook for the treatment of dermatologic diseases.
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