妊娠期跑轮能缓解小鼠产后焦虑和抑郁样行为:NLRP3神经炎症体激活、催乳素和海马中催乳素受体的作用

IF 3.7 3区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Neurochemical Research Pub Date : 2024-06-21 DOI:10.1007/s11064-024-04180-2
Yixin Li, Lin Zhou, Ling Xiao, Huiling Wang, Gaohua Wang
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引用次数: 0

摘要

尽管产后抑郁症在孕产妇疾病中的发病率有所上升,但其治疗效果仍不理想。研究表明,运动可以减少产妇产后抑郁发作,但人们对孕期运动对产妇行为的影响及其潜在机制仍知之甚少。从怀孕第二天到分娩当天,母马每天在一个可控的轮子上跑步锻炼 1 小时。产后第2天至第8天对母鼠的母性行为进行了评估。从产后第2天到第12天,对母鼠施加慢性束缚应激。在产后第3天和第8天采集血液,然后用酶联免疫吸附法测定血清中催乳素的浓度。记录每只母鼠的体重和进食量。进行了焦虑和抑郁样行为测试,并测量了海马神经炎症和催乳素受体水平。结果表明,在诱导产后慢性束缚应激后,母马表现出焦虑和抑郁水平升高、血清催乳素水平下降、催乳素受体表达减少以及海马中NLRP3介导的神经炎症激活,而在孕期控制车轮跑步可逆转这些症状。总之,本研究结果显示,孕期运动对产后焦虑和抑郁样行为的预防作用伴随着血清催乳素水平、海马催乳素受体表达和海马NLRP3介导的神经炎症的增加。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Wheel Running During Pregnancy Alleviates Anxiety-and Depression-Like Behaviors During the Postpartum Period in Mice: The Roles of NLRP3 Neuroinflammasome Activation, Prolactin, and the Prolactin Receptor in the Hippocampus

Despite the increase in the prevalence of postpartum depression among maternal disorder, its treatment outcomes remain suboptimal. Studies have shown that exercise can reduce postpartum depressive episodes in the mother, but the effects of exercise during pregnancy on maternal behavior and the potential mechanisms involved remain poorly understood. From the second day of pregnancy to the day of birth, dams exercised for 1 h a day by running on a controlled wheel. The maternal behaviors of the dams were assessed on postpartum day 2 to postpartum day 8. Chronic restraint stress was applied from postpartum day 2 to day 12. Blood was collected on postpartum days 3 and 8, then subjected to ELISA to determine the serum concentration of prolactin. The weight of each dam and the food intake were recorded. Anxiety- and depression-like behavioral tests were conducted, and hippocampal neuroinflammation and prolactin receptor levels were measured. The dams exhibited elevated levels of anxiety and depression, decreased serum prolactin levels, decreased prolactin receptor expression, and activation of NLRP3-mediated neuroinflammation in the hippocampus following the induction of postpartum chronic restraint stress, which were reversed with controlled wheel running during pregnancy. Overall, the findings of this study revealed that the preventive effects of exercise during pregnancy on postpartum anxiety-and depression-like behaviors were accompanied by increased serum prolactin levels, hippocampal prolactin receptor expression and hippocampal NLRP3-mediated neuroinflammation.

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来源期刊
Neurochemical Research
Neurochemical Research 医学-神经科学
CiteScore
7.70
自引率
2.30%
发文量
320
审稿时长
6 months
期刊介绍: Neurochemical Research is devoted to the rapid publication of studies that use neurochemical methodology in research on nervous system structure and function. The journal publishes original reports of experimental and clinical research results, perceptive reviews of significant problem areas in the neurosciences, brief comments of a methodological or interpretive nature, and research summaries conducted by leading scientists whose works are not readily available in English.
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