Wiktoria Tomal, Filip Petko, Mariusz Galek, Andrzej Świeży, Małgorzata Tyszka-Czochara, Patrycja Środa, Krystian Mokrzyński and Joanna Ortyl*,
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引用次数: 0
摘要
本文介绍了五种以前未知的安息香缩酮基衍生物，它们是用于生物医学应用的自由基光聚合过程的水溶性 I 型光引发剂。这些化合物在长波紫外线和 500 纳米可见光范围内具有优异的光谱特性，在水中的溶解性更强，细胞毒性更低，与生物医学应用中常用的光引发剂相比取得了重大进展。研究发现，所开发的新型安息香衍生物可有效光引发丙烯酸酯单体的自由基聚合，包括在水介质中形成水凝胶材料。此外，这些化合物还可用于先进的应用领域，包括利用增值税打印技术制造具有复杂几何形状的水凝胶细胞外基质。所述研究是开发生物医学应用水溶性光引发剂的重大进展。
Water-Soluble Type I Radical Photoinitiators Dedicated to Obtaining Microfabricated Hydrogels
Herein, five previously unknown benzoin ketal-based derivatives are presented as water-soluble, type I photoinitiators of free-radical photopolymerization processes for biomedical applications. Excellent spectroscopic properties of these compounds in the longwave ultraviolet and visible range up to 500 nm, enhanced solubility in water, and low cytotoxicity have been successfully proved, marking a significant advance over commonly used photoinitiators for biomedical applications. The developed new benzoin derivatives have been found to be effective in photoinitiating the free-radical polymerization of acrylate monomers, including the formation of hydrogel materials in aqueous media. In addition, these compounds can be used in advanced applications, including manufacturing of a hydrogel extracellular matrix with complex geometries using VAT printing. The described research represents a significant advance in the development of water-soluble photoinitiators for biomedical applications.
期刊介绍：
The journal Chemistry of Materials focuses on publishing original research at the intersection of materials science and chemistry. The studies published in the journal involve chemistry as a prominent component and explore topics such as the design, synthesis, characterization, processing, understanding, and application of functional or potentially functional materials. The journal covers various areas of interest, including inorganic and organic solid-state chemistry, nanomaterials, biomaterials, thin films and polymers, and composite/hybrid materials. The journal particularly seeks papers that highlight the creation or development of innovative materials with novel optical, electrical, magnetic, catalytic, or mechanical properties. It is essential that manuscripts on these topics have a primary focus on the chemistry of materials and represent a significant advancement compared to prior research. Before external reviews are sought, submitted manuscripts undergo a review process by a minimum of two editors to ensure their appropriateness for the journal and the presence of sufficient evidence of a significant advance that will be of broad interest to the materials chemistry community.
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