{"title":"通过形成 EDA 复合物加速 N-苯甲酰基胺与草酸盐的光化学还原羧化反应","authors":"Wen-Wen Liu, Pei Xu, Hui-Xian Jiang, Meng-Lei Li, Tian-Zi Hao, Yi-Qin Liu, Song-Lei Zhu, Kun-Xiao Zhang* and Xu Zhu*, ","doi":"10.1021/acscatal.4c02007","DOIUrl":null,"url":null,"abstract":"<p >Herein, a visible-light-induced umpolung strategy for reductive carboxylation of imines for synthesis of unnatural α-amino acids was disclosed. A reaction mechanism involving electron-donor–acceptor (EDA) complex formation between substrate and oxalate to furnish the desired products was proposed. Oxalic salt in situ generates CO<sub>2</sub> radical anion (CO<sub>2</sub><sup>•–</sup>) and carbon dioxide (CO<sub>2</sub>) as the key single-electron reductant and carbonyl (C1) source, respectively, during the transformation with or without photocatalyst.</p>","PeriodicalId":9,"journal":{"name":"ACS Catalysis ","volume":null,"pages":null},"PeriodicalIF":11.3000,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Photochemical Reductive Carboxylation of N-Benzoyl Imines with Oxalate Accelerated by Formation of EDA Complexes\",\"authors\":\"Wen-Wen Liu, Pei Xu, Hui-Xian Jiang, Meng-Lei Li, Tian-Zi Hao, Yi-Qin Liu, Song-Lei Zhu, Kun-Xiao Zhang* and Xu Zhu*, \",\"doi\":\"10.1021/acscatal.4c02007\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p >Herein, a visible-light-induced umpolung strategy for reductive carboxylation of imines for synthesis of unnatural α-amino acids was disclosed. A reaction mechanism involving electron-donor–acceptor (EDA) complex formation between substrate and oxalate to furnish the desired products was proposed. Oxalic salt in situ generates CO<sub>2</sub> radical anion (CO<sub>2</sub><sup>•–</sup>) and carbon dioxide (CO<sub>2</sub>) as the key single-electron reductant and carbonyl (C1) source, respectively, during the transformation with or without photocatalyst.</p>\",\"PeriodicalId\":9,\"journal\":{\"name\":\"ACS Catalysis \",\"volume\":null,\"pages\":null},\"PeriodicalIF\":11.3000,\"publicationDate\":\"2024-06-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ACS Catalysis \",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://pubs.acs.org/doi/10.1021/acscatal.4c02007\",\"RegionNum\":1,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, PHYSICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Catalysis ","FirstCategoryId":"92","ListUrlMain":"https://pubs.acs.org/doi/10.1021/acscatal.4c02007","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}
Photochemical Reductive Carboxylation of N-Benzoyl Imines with Oxalate Accelerated by Formation of EDA Complexes
Herein, a visible-light-induced umpolung strategy for reductive carboxylation of imines for synthesis of unnatural α-amino acids was disclosed. A reaction mechanism involving electron-donor–acceptor (EDA) complex formation between substrate and oxalate to furnish the desired products was proposed. Oxalic salt in situ generates CO2 radical anion (CO2•–) and carbon dioxide (CO2) as the key single-electron reductant and carbonyl (C1) source, respectively, during the transformation with or without photocatalyst.
期刊介绍：
ACS Catalysis is an esteemed journal that publishes original research in the fields of heterogeneous catalysis, molecular catalysis, and biocatalysis. It offers broad coverage across diverse areas such as life sciences, organometallics and synthesis, photochemistry and electrochemistry, drug discovery and synthesis, materials science, environmental protection, polymer discovery and synthesis, and energy and fuels.
The scope of the journal is to showcase innovative work in various aspects of catalysis. This includes new reactions and novel synthetic approaches utilizing known catalysts, the discovery or modification of new catalysts, elucidation of catalytic mechanisms through cutting-edge investigations, practical enhancements of existing processes, as well as conceptual advances in the field. Contributions to ACS Catalysis can encompass both experimental and theoretical research focused on catalytic molecules, macromolecules, and materials that exhibit catalytic turnover.
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