Linda Kollenburg, Erkan Kurt, Wim Mulleners, Alaa Abd-Elsayed, Cyrus Yazdi, Michael E Schatman, R Jason Yong, Ivo H Cerda, Adlai Pappy, Sait Ashina, Christopher Louis Robinson, Moises Dominguez
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引用次数: 0
摘要
审查目的：慢性头痛是导致全球残疾的一个重要原因。尽管已开发出常规治疗策略，但仍有一部分患者在接受这些治疗后仍难治和/或出现副作用。因此，枕神经刺激疗法（ONS）应被视为治疗顽固性慢性头痛的替代方法。本综述旨在全面概述枕神经刺激疗法治疗头痛疾病的有效性、安全性、机制和实际应用：在丛集性头痛、慢性偏头痛和枕神经痛患者中，ONS的总体反应率分别为35.7%-100%、17%-100%和63%-100%。在所有组别的长期疗效方面，41.6%-88.0%的患者在≥18.3个月后仍有反应。最常见的不良反应包括导线移位/断裂（13%）和局部疼痛（7.3%）。根据我们的研究结果，可以认为 ONS 是治疗慢性顽固性头痛疾病的一种安全有效的方法。为支持更广泛地应用ONS，应进行更多的样本研究。
Four Decades of Occipital Nerve Stimulation for Headache Disorders: A Systematic Review.
Purpose of review: Chronic headaches are a significant source of disability worldwide. Despite the development of conventional strategies, a subset of patients remain refractory and/or experience side effects following these treatments. Hence, occipital nerve stimulation (ONS) should be considered as an alternative strategy for intractable chronic headaches. This review aims to provide a comprehensive overview of the effectiveness, safety, mechanisms and practical application of ONS for the treatment of headache disorders.
Recent findings: Overall response rate of ONS is 35.7-100%, 17-100%, and 63-100% in patients with cluster headache, chronic migraine and occipital neuralgia respectively. Regarding the long-term effectivity in all groups, 41.6-88.0% of patients remain responders after ≥ 18.3 months. The most frequently reported adverse events include lead migration/fracture (13%) and local pain (7.3%). Based on our results, ONS can be considered a safe and effective treatment for chronic intractable headache disorders. To support more widespread application of ONS, additional research with larger sample sizes should be conducted.
期刊介绍：
This journal aims to review the most important, recently published clinical findings regarding the diagnosis, treatment, and management of pain and headache. By providing clear, insightful, balanced contributions by international experts, the journal intends to serve all those involved in the care and prevention of pain and headache.
We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as anesthetic techniques in pain management, cluster headache, neuropathic pain, and migraine. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.
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