印度 1 型糖尿病儿童和青少年的动态肌肉功能参数:病例对照研究

Sonal V Kasture, Shruti A Mondkar, Anuradha V Khadilkar, Ketan Gondhalekar, Anshu Sethi, Vaman V Khadilkar
{"title":"印度 1 型糖尿病儿童和青少年的动态肌肉功能参数:病例对照研究","authors":"Sonal V Kasture, Shruti A Mondkar, Anuradha V Khadilkar, Ketan Gondhalekar, Anshu Sethi, Vaman V Khadilkar","doi":"10.4103/ijem.ijem_140_23","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Recent evidence reveals that type 1 diabetes mellitus (T1DM) impairs muscle function (MF) in adolescents. However, despite its importance in physical well-being, data on dynamic MF in Indian children and adolescents (C and Y) with T1DM are scarce. We assessed MF using Jumping Mechanography (JM, a measurement method for motion analysis and assessment of muscle power and force). (1) To assess dynamic MF by JM in C and Y with T1DM as compared to healthy controls (2) To determine predictors of MF in children with T1DM.</p><p><strong>Methods: </strong>A cross-sectional observational study on 266 children (133 - T1DM duration >1 year with no known comorbidities + 133 age and gender-matched healthy controls) aged 6-19 years. Anthropometry, body composition, and MF (maximum relative power Pmax/mass, maximum relative force Fmax/BW by JM) were recorded. The lean mass index (LMI) was calculated as lean mass (kg)/height (m<sup>2</sup>). HbA1c was assessed in T1DM. Independent sample <i>t</i>-test and linear regression were performed.</p><p><strong>Results: </strong>MF parameters (Pmax/mass 33.5 ± 7.2 vs 38.0 ± 8.6 W/kg and Fmax/BW 10.5 ± 2.9 vs 11.4 ± 4.1 N/kg, <i>P</i> < 0.05) were significantly lower in T1DM group vs controls. Positive association of body mass index and LMI with both MF parameters and negative association of insulin requirement and HbA1c with Fmax was observed in T1DM. Predictors of MF identified were MMI (Pmax/mass:b = 1.6,95%CI = 0.6-2.6; Fmax/BW:b =2.0,95%CI = 1.6-2.4) and HbA1c (Pmax/mass:b = -2.1,95%CI = -4.5--0.5; Fmax/BW:b = -1.1,95%CI = -2.0--0.2) (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>C and Y with T1DM exhibits compromised muscle function. Poor glycaemic control increases the risk of having decreased MF, irrespective of diabetes duration and may contribute to sarcopenia in adulthood.</p>","PeriodicalId":13353,"journal":{"name":"Indian Journal of Endocrinology and Metabolism","volume":"28 2","pages":"201-207"},"PeriodicalIF":0.0000,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11189292/pdf/","citationCount":"0","resultStr":"{\"title\":\"Dynamic Muscle Function Parameters in Indian Children and Adolescents with Type 1 Diabetes Mellitus: A Case-Control Study.\",\"authors\":\"Sonal V Kasture, Shruti A Mondkar, Anuradha V Khadilkar, Ketan Gondhalekar, Anshu Sethi, Vaman V Khadilkar\",\"doi\":\"10.4103/ijem.ijem_140_23\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>Recent evidence reveals that type 1 diabetes mellitus (T1DM) impairs muscle function (MF) in adolescents. However, despite its importance in physical well-being, data on dynamic MF in Indian children and adolescents (C and Y) with T1DM are scarce. We assessed MF using Jumping Mechanography (JM, a measurement method for motion analysis and assessment of muscle power and force). (1) To assess dynamic MF by JM in C and Y with T1DM as compared to healthy controls (2) To determine predictors of MF in children with T1DM.</p><p><strong>Methods: </strong>A cross-sectional observational study on 266 children (133 - T1DM duration >1 year with no known comorbidities + 133 age and gender-matched healthy controls) aged 6-19 years. Anthropometry, body composition, and MF (maximum relative power Pmax/mass, maximum relative force Fmax/BW by JM) were recorded. The lean mass index (LMI) was calculated as lean mass (kg)/height (m<sup>2</sup>). HbA1c was assessed in T1DM. Independent sample <i>t</i>-test and linear regression were performed.</p><p><strong>Results: </strong>MF parameters (Pmax/mass 33.5 ± 7.2 vs 38.0 ± 8.6 W/kg and Fmax/BW 10.5 ± 2.9 vs 11.4 ± 4.1 N/kg, <i>P</i> < 0.05) were significantly lower in T1DM group vs controls. Positive association of body mass index and LMI with both MF parameters and negative association of insulin requirement and HbA1c with Fmax was observed in T1DM. Predictors of MF identified were MMI (Pmax/mass:b = 1.6,95%CI = 0.6-2.6; Fmax/BW:b =2.0,95%CI = 1.6-2.4) and HbA1c (Pmax/mass:b = -2.1,95%CI = -4.5--0.5; Fmax/BW:b = -1.1,95%CI = -2.0--0.2) (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>C and Y with T1DM exhibits compromised muscle function. Poor glycaemic control increases the risk of having decreased MF, irrespective of diabetes duration and may contribute to sarcopenia in adulthood.</p>\",\"PeriodicalId\":13353,\"journal\":{\"name\":\"Indian Journal of Endocrinology and Metabolism\",\"volume\":\"28 2\",\"pages\":\"201-207\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11189292/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Indian Journal of Endocrinology and Metabolism\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4103/ijem.ijem_140_23\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/4/29 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Indian Journal of Endocrinology and Metabolism","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/ijem.ijem_140_23","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/4/29 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

导言:最新证据显示,1 型糖尿病(T1DM)会损害青少年的肌肉功能(MF)。然而,尽管肌肉功能对身体健康非常重要,但有关患有 T1DM 的印度儿童和青少年(C 和 Y)动态肌肉功能的数据却很少。我们使用跳跃力学成像(JM,一种用于运动分析和肌肉力量与作用力评估的测量方法)对肌肉力量进行了评估。(1)与健康对照组相比,通过 JM 评估患有 T1DM 的 C 和 Y 的动态 MF;(2)确定 T1DM 儿童 MF 的预测因素:对 266 名 6-19 岁儿童(133 名 T1DM 病程超过 1 年且无已知合并症的儿童 + 133 名年龄和性别匹配的健康对照组)进行横断面观察研究。研究记录了人体测量、身体成分和最大相对力量(最大相对力量 Pmax/体重、最大相对力量 Fmax/JM)。瘦体重指数(LMI)按瘦体重(公斤)/身高(平方米)计算。对 T1DM 进行 HbA1c 评估。进行了独立样本 t 检验和线性回归:MF参数(Pmax/mass 33.5 ± 7.2 vs 38.0 ± 8.6 W/kg,Fmax/BW 10.5 ± 2.9 vs 11.4 ± 4.1 N/kg,P < 0.05)在T1DM组与对照组相比明显较低。在 T1DM 组中,体重指数和 LMI 与 MF 参数均呈正相关,而胰岛素需求量和 HbA1c 与 Fmax 呈负相关。MF的预测因子为MMI(Pmax/mass:b = 1.6,95%CI = 0.6-2.6;Fmax/BW:b = 2.0,95%CI = 1.6-2.4)和HbA1c(Pmax/mass:b = -2.1,95%CI = -4.5--0.5;Fmax/BW:b = -1.1,95%CI = -2.0--0.2)(P < 0.05):结论:患有T1DM的C和Y表现出肌肉功能受损。无论糖尿病持续时间长短,血糖控制不佳都会增加肌肉功能下降的风险,并可能导致成年期肌肉疏松症。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Dynamic Muscle Function Parameters in Indian Children and Adolescents with Type 1 Diabetes Mellitus: A Case-Control Study.

Introduction: Recent evidence reveals that type 1 diabetes mellitus (T1DM) impairs muscle function (MF) in adolescents. However, despite its importance in physical well-being, data on dynamic MF in Indian children and adolescents (C and Y) with T1DM are scarce. We assessed MF using Jumping Mechanography (JM, a measurement method for motion analysis and assessment of muscle power and force). (1) To assess dynamic MF by JM in C and Y with T1DM as compared to healthy controls (2) To determine predictors of MF in children with T1DM.

Methods: A cross-sectional observational study on 266 children (133 - T1DM duration >1 year with no known comorbidities + 133 age and gender-matched healthy controls) aged 6-19 years. Anthropometry, body composition, and MF (maximum relative power Pmax/mass, maximum relative force Fmax/BW by JM) were recorded. The lean mass index (LMI) was calculated as lean mass (kg)/height (m2). HbA1c was assessed in T1DM. Independent sample t-test and linear regression were performed.

Results: MF parameters (Pmax/mass 33.5 ± 7.2 vs 38.0 ± 8.6 W/kg and Fmax/BW 10.5 ± 2.9 vs 11.4 ± 4.1 N/kg, P < 0.05) were significantly lower in T1DM group vs controls. Positive association of body mass index and LMI with both MF parameters and negative association of insulin requirement and HbA1c with Fmax was observed in T1DM. Predictors of MF identified were MMI (Pmax/mass:b = 1.6,95%CI = 0.6-2.6; Fmax/BW:b =2.0,95%CI = 1.6-2.4) and HbA1c (Pmax/mass:b = -2.1,95%CI = -4.5--0.5; Fmax/BW:b = -1.1,95%CI = -2.0--0.2) (P < 0.05).

Conclusion: C and Y with T1DM exhibits compromised muscle function. Poor glycaemic control increases the risk of having decreased MF, irrespective of diabetes duration and may contribute to sarcopenia in adulthood.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Indian Journal of Endocrinology and Metabolism
Indian Journal of Endocrinology and Metabolism Medicine-Endocrinology, Diabetes and Metabolism
CiteScore
2.10
自引率
0.00%
发文量
75
期刊介绍: The Indian Journal of Endocrinology and Metabolism (IJEM) aims to function as the global face of Indian endocrinology research. It aims to act as a bridge between global and national advances in this field. The journal publishes thought-provoking editorials, comprehensive reviews, cutting-edge original research, focused brief communications and insightful letters to editor. The journal encourages authors to submit articles addressing aspects of science related to Endocrinology and Metabolism in particular Diabetology. Articles related to Clinical and Tropical endocrinology are especially encouraged. Sub-topic based Supplements are published regularly. This allows the journal to highlight issues relevant to Endocrine practitioners working in India as well as other countries. IJEM is free access in the true sense of the word, (it charges neither authors nor readers) and this enhances its global appeal.
期刊最新文献
The Burden of Diabetic Foot Ulcers in Urban India: A Community Healthcare Setup-Based Study. Approved and Emerging Hormone-Based Anti-Obesity Medications: A Review Article. Assessment of Correlation Between Glycaemic Variability Indices and Measures of Hypoglycaemia in Patients with Type 2 Diabetes Mellitus. Association Between Type 2 Diabetes and Hypogonadism in India: An Observational Study. Carotid Intima-Media Thickness and Sheehan's Syndrome.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1