坦桑尼亚乞力马扎罗山地区艾滋病病毒感染者忘记服药、坚持治疗及其与病毒载量抑制的关系。

IF 1.5 Q4 INFECTIOUS DISEASES HIV AIDS-Research and Palliative Care Pub Date : 2024-06-17 eCollection Date: 2024-01-01 DOI:10.2147/HIV.S452875
Lyidia V Masika, Innocent B Mboya, Rehema Anenmose Maro, Benson Mtesha, Mtoro J Mtoro, Kennedy Ngowi, Michael Johnson Mahande, I Marion Sumari-de Boer
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引用次数: 0

摘要

背景:坚持抗逆转录病毒疗法(ART)对于艾滋病病毒感染者(PLHIV)的病毒学抑制和积极治疗效果至关重要,但在确保患者实现并维持病毒载量抑制方面仍存在挑战。尽管建议使用数字工具提醒服药,但忘记服药的影响尚不清楚。本研究调查了忘记服药对漏服药物总量的影响及其对可检测到的病毒载量(VL)的影响:这项混合方法研究的对象是坦桑尼亚北部接受抗逆转录病毒疗法的儿童、青少年、孕妇和哺乳期女性艾滋病感染者。遗忘服药是指因遗忘而漏服药物。采用多变量逻辑回归模型估算调整后的几率比(AOR)和 95% 的置信区间(CI),以确定忘记服药对总漏服药物量的影响以及与检测到 VL 相关的其他因素:在 427 名受访者中,33.3% 是儿童,33.4% 是青少年,33.3% 是孕妇和哺乳期妇女,她们的中位年龄(四分位数间距)分别为 9(7-12)岁、18(16-18)岁和 31(27-36)岁。有 92 人(22.3%)报告在过去一个月中遗漏服药,其中 72 人(17.9%)是因为忘记服药。忘记服药(AOR:1.75 95% CI:1.01-3.06)和服用二线药物(AOR:2.89 95% CI:1.50-5.55)会增加检测到 VL 的几率,而女性检测到 VL 的几率较低(AOR:0.62 95% CI:0.41-0.98)。定性结果中关于忘记服药原因的主题包括工作繁忙和提醒的重要性:结论:忘记服药在 PLHIV 中很常见,也是检测到 VL 的一个重要预测因素。这就需要使用自动短信服务(SMS)提醒或带有提醒功能的数字坚持治疗工具来改善和促进艾滋病毒携带者坚持抗逆转录病毒疗法。
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Forgetting to Take Medication, Treatment Adherence and Their Relationship with Viral Load Suppression Among People Living with HIV in the Kilimanjaro Region, Tanzania.

Background: Antiretroviral therapy (ART) adherence is crucial for virological suppression and positive treatment outcomes among people living with HIV (PLHIV), but remains a challenge in ensuring patients achieve and sustain viral load suppression. Despite the recommended use of digital tools medications uptake reminders, the contribution of forgetting to take medication is unknown. This study investigated the contribution of forgetting to take medication on the total missed medication and its effects on detectable viral load (VL).

Methods: This mixed-method research was conducted among children, adolescents, pregnant, and breastfeeding women living with HIV on ART in northern Tanzania. Forgetting to take medication constituted reporting to have missed medication due to forgetfulness. A multivariable logistic regression model was used to estimate the adjusted odds ratio (AOR) with a 95% confidence interval (CI) to determine the contribution of forgetting medication intakes on total missed medication and other factors associated with having a detectable VL.

Results: Of 427 respondents, 33.3% were children, 33.4% adolescents, and 33.3% pregnant and breastfeeding women, whose median age (interquartile range) was 9 (7-12), 18 (16-18), and 31 (27-36) years, respectively. Ninety-two (22.3%) reported missing medication over the past month, of which 72 (17.9%) was due to forgetting. Forgetting to take medication (AOR: 1.75 95% CI: 1.01-3.06) and being on second-line regimen (AOR: 2.89 95% CI: 1.50-5.55) increased the chances of a detectable VL, while females had lower chances of detectable VL (AOR: 0.62 95% CI: 0.41-0.98). The themes on the reasons for forgetting to take medication from qualitative results included being busy with work and the importance of reminders.

Conclusion: Forgetting to take medication is common among PLHIV and an important predictor of a detectable VL. This calls for the use of automated short message services (SMS) reminders or Digital Adherence Tools with reminders to improve and promote good ART adherence among PLHIV.

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来源期刊
CiteScore
3.00
自引率
6.70%
发文量
61
审稿时长
16 weeks
期刊介绍: About Dove Medical Press Dove Medical Press Ltd is part of Taylor & Francis Group, the Academic Publishing Division of Informa PLC. We specialize in the publication of Open Access peer-reviewed journals across the broad spectrum of science, technology and especially medicine. Dove Medical Press was founded in 2003 with the objective of combining the highest editorial standards with the ''best of breed'' new publishing technologies. We have offices in Manchester and London in the United Kingdom, representatives in Princeton, New Jersey in the United States, and our editorial offices are in Auckland, New Zealand. Dr Scott Fraser is our Medical Director based in the UK. He has been in full time clinical practice for over 20 years as well as having an active research interest.
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