用沙雷霉素治疗口周皮炎患者队列的回顾性研究

Q2 Medicine Journal of Clinical and Aesthetic Dermatology Pub Date : 2024-06-01
Kirsten Swenson, Aliza Stern, Emmy Graber
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引用次数: 0

摘要

简介:口周皮炎(POD)是一种常见的慢性面部炎症性皮疹,表现为微小丘疹和丘疹性脓疱,下层为湿疹样斑块,通常局限于口周、脐周和眶周。目前,美国食品和药物管理局(FDA)还没有指定治疗 POD 的方法;不过,广谱抗生素是一种有效的治疗选择。广谱抗生素会对肠道菌群产生负面影响,导致抗生素耐药性。窄谱四环素类药物(如沙瑞霉素)产生细菌耐药性和胃肠道问题的可能性较低:我们进行了一项回顾性病历审查,以评估使用沙瑞环素治疗的 POD 患者群中沙瑞环素的疗效:方法:使用电子病历完成病历回顾。纳入标准包括年龄在 18 至 95 岁之间、诊断为 POD、接受过沙雷霉素治疗并有随访记录的男性和女性:结果:有六名患者符合纳入标准,所有患者的病情均有所好转,且无任何副作用报告。六名患者中,四名女性,两名男性,年龄从 26 岁到 58 岁不等(平均年龄为 41 岁)。疗程从 30 天到 180 天不等(中位数=90 天):根据研究结果,与其他四环素类抗生素相比,沙雷霉素治疗 POD 有许多潜在的益处。有必要开展更大规模的临床研究,评估 POD 的治疗方案。鉴于沙雷霉素在大规模痤疮研究中的疗效和耐受性,沙雷霉素可能是治疗 POD 的一种合适的新疗法,应进一步加以探讨。
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A Retrospective Review of a Cohort of Patients with Periorificial Dermatitis Treated with Sarecycline.

Introduction: Periorificial dermatitis (POD) is a common, chronic, inflammatory facial skin rash that presents as tiny papules and papulopustules with underlying eczematous-like patches, typically confined to the perioral, perinasal, and periorbital areas. There is currently no Food and Drug Administration (FDA)-indicated treatment for POD; however, broad-spectrum antibiotics are efficacious as a treatment option. Broad-spectrum antibiotics negatively impact gut flora and lead to antibiotic resistance. Narrow-spectrum tetracyclines, such as sarecycline, have a low potential for promoting bacterial resistance and gastrointestinal issues.

Objective: We conducted a retrospective chart review in order to evaluate the efficacy of sarecycline in a cohort of patients diagnosed with POD that were treated with sarecycline.

Methods: A review of medical records was completed using an electronic medical record. Inclusion criteria included males and females aged 18 to 95 with a diagnosis of POD, treated with sarecycline with a documented follow-up.

Results: Six patients met inclusion criteria, all of which had shown improvement with no reported side effects. Of the six patients, four were female and two were male and the patient ages ranged from 26 to 58 years old (mean=41 years). The course of therapy ranged from 30 to180 days (median=90 days).

Conclusion: Based on the outcomes, there are many potential benefits to treatment of POD with sarecycline over the alternative tetracycline-class antibiotics. There is a need for more large-scale clinical studies evaluating treatment options for POD. Based on the efficacy and tolerability of sarecycline in large- scale acne studies, sarecycline may be an appropriate novel treatment option for POD and should be explored further.

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CiteScore
2.60
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发文量
104
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