条件辨别和抑制神经生物学研究的转化方法:对精神疾病的影响。

IF 1.6 4区 医学 Q3 BEHAVIORAL SCIENCES Behavioral neuroscience Pub Date : 2024-08-01 Epub Date: 2024-06-24 DOI:10.1037/bne0000594
Susan Sangha, Jacklynn M Fitzgerald
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引用次数: 0

摘要

越来越多的研究调查了辨别性恐惧条件反射和条件性恐惧抑制,以评估安全学习,以及提示性恐惧的消退。尽管所有这些范式都会导致恐惧表达的减少,但它们之间存在着细微的差异,这些差异可能是通过不同的行为和神经机制介导的。这些差异可能会影响我们如何在临床上治疗恐惧反应失调的疾病。本综述旨在概述在动物模型和人类神经精神疾病中报道的条件辨别和抑制结果。本文综述了人类和啮齿类动物的行为和神经研究结果,这些研究包括通过有强化和无强化的条件刺激(分别为 CS+ 和 CS-)进行的条件性恐惧辨别,以及/或通过评估对 CS-/CS+ 和 CS+ 复合线索的恐惧反应进行的条件性恐惧抑制。不同物种在行为恐惧表达以及神经回路方面存在若干相似之处,这些神经回路可促进对 CS- 和/或 CS-/CS+ 复合线索的恐惧反应的减少。我们需要继续加大力度比较不同物种间类似的行为恐惧抑制范式,以便在理解和治疗恐惧障碍患者方面取得突破性进展。(PsycInfo Database Record (c) 2024 APA,保留所有权利)。
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Translational approaches to the neurobiological study of conditional discrimination and inhibition: Implications for psychiatric disease.

There is a growing number of studies investigating discriminatory fear conditioning and conditioned inhibition of fear to assess safety learning, in addition to extinction of cued fear. Despite all of these paradigms resulting in a reduction in fear expression, there are nuanced differences among them, which could be mediated through distinct behavioral and neural mechanisms. These differences could impact how we approach potential treatment options in clinical disorders with dysregulated fear responses. The objective of this review is to give an overview of the conditional discrimination and inhibition findings reported in both animal models and human neuropsychiatric disorders. Both behavioral and neural findings are reviewed among human and rodent studies that include conditional fear discrimination via conditional stimuli with and without reinforcement (CS+ vs. CS-, respectively) and/or conditional inhibition of fear through assessment of the fear response to a compound CS-/CS+ cue versus CS+. There are several parallels across species in behavioral fear expression as well as neural circuits promoting fear reduction in response to a CS- and/or CS-/CS+ compound cue. Continued and increased efforts to compare similar behavioral fear inhibition paradigms across species are needed to make breakthrough advances in our understanding and treatment approaches to individuals with fear disorders. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

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来源期刊
Behavioral neuroscience
Behavioral neuroscience 医学-行为科学
CiteScore
3.40
自引率
0.00%
发文量
51
审稿时长
6-12 weeks
期刊介绍: Behavioral Neuroscience publishes original research articles as well as reviews in the broad field of the neural bases of behavior.
期刊最新文献
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