心外膜脂肪组织和残余心血管风险:利拉鲁肽的综合病例分析和治疗启示。

IF 2.9 3区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Journal of Cardiovascular Medicine Pub Date : 2024-08-01 Epub Date: 2024-06-20 DOI:10.2459/JCM.0000000000001652
Fulvio Cacciapuoti, Ciro Mauro, Davide D'Andrea, Valentina Capone, Carlo Liguori, Federico Cacciapuoti
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引用次数: 0

摘要

导言:近年来,心外膜脂肪组织(EAT)在心血管健康中的作用发生了范式转变,从一个被动的储存库演变成心血管风险的动态贡献者。本病例批判性地研究了 EAT 的多方面功能,探讨了其对心血管风险的影响,并讨论了 GLP-1 受体激动剂利拉鲁肽在减轻其影响方面的潜在益处:我们介绍的病例是一位 62 岁的男性患者,他肥胖、高血压并有慢性冠状动脉综合征病史。他因主诉心悸和气短被送入急诊室。12 导联心电图显示心房颤动伴有快速心室反应,并有新发左束支传导阻滞的证据。经胸超声心动图显示心率依赖性区域运动障碍,而超声心动图和计算机断层扫描结果均显示存在厚EAT。冠状动脉造影显示,左前降支动脉存在血管内再狭窄,患者接受了经皮血运重建治疗。为了应对残余的心血管风险,患者在住院期间开始服用利拉鲁肽。随访结果显示,患者的低密度脂蛋白胆固醇和高敏C反应蛋白水平降低,EAT厚度和体重指数下降,超声心动图参数也有所改善:讨论:鉴于 EAT 在心血管风险中的积极作用,旨在减少 EAT 的针对性干预措施势在必行。GLP-1 受体激动剂(如利拉鲁肽)有望减轻 EAT 的影响,是解决残余心血管风险的潜在治疗途径。
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Epicardial adipose tissue and residual cardiovascular risk: a comprehensive case analysis and therapeutic insights with Liraglutide.
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来源期刊
Journal of Cardiovascular Medicine
Journal of Cardiovascular Medicine 医学-心血管系统
CiteScore
3.90
自引率
26.70%
发文量
189
审稿时长
6-12 weeks
期刊介绍: Journal of Cardiovascular Medicine is a monthly publication of the Italian Federation of Cardiology. It publishes original research articles, epidemiological studies, new methodological clinical approaches, case reports, design and goals of clinical trials, review articles, points of view, editorials and Images in cardiovascular medicine. Submitted articles undergo a preliminary review by the editor. Some articles may be returned to authors without further consideration. Those being considered for publication will undergo further assessment and peer-review by the editors and those invited to do so from a reviewer pool. ​
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