重复经颅磁刺激对大脑皮层活动的影响:利用功能性近红外光谱评估进行的系统回顾和荟萃分析。

IF 5.2 2区 医学 Q1 ENGINEERING, BIOMEDICAL Journal of NeuroEngineering and Rehabilitation Pub Date : 2024-06-24 DOI:10.1186/s12984-024-01407-9
Shao-Yu Chen, Meng-Hsuan Tsou, Kuan-Yu Chen, Yan-Ci Liu, Meng-Ting Lin
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引用次数: 0

摘要

背景:重复经颅磁刺激(rTMS)可引起大脑皮层兴奋性的改变并促进神经可塑性。为了精确量化这些效应,人们在使用经颅磁刺激的同时还使用了功能性近红外光谱(fNIRS)--一种善于检测大脑皮层血流动力学反应变化的光学神经成像模式--来测量和调整不同经颅磁刺激方案对大脑皮层的影响:本系统综述和荟萃分析旨在阐明经颅磁刺激对 fNIRS 检测到的初级运动皮层(M1)皮层血流动力学反应的影响:在 PubMed、Embase 和 Scopus 数据库中系统检索了利用经颅磁刺激 M1 皮层并结合 fNIRS 评估皮质活动的原创文章。搜索范围包括从这些数据库建立之初到 2024 年 4 月的记录。同时还进行了偏倚风险评估。还对可提取原始数据的研究进行了荟萃分析:在 312 项研究中,有 14 篇文章符合定性审查的条件。7项研究符合荟萃分析条件。对 M1 皮层采用了多种经颅磁刺激方案。在抑制性经颅磁刺激中,多项研究观察到同侧 M1 的氧合血红蛋白 [HbO] 浓度降低,而对侧 M1 的氧合血红蛋白浓度升高。Meta 分析也证实了这一一致的趋势。然而,某些研究发现双侧 M1 的[HbO]有所降低。有几项研究还描述了不同皮质区域之间错综复杂的抑制或兴奋相互作用:结论:不同的经颅磁刺激方案导致 fNIRS 检测到的皮质活动模式各不相同。元分析显示,低频抑制性经颅磁刺激后,对侧皮质的[HbO]呈上升趋势,同侧皮质的[HbO]呈下降趋势。然而,由于不同研究之间存在异质性,有必要开展进一步研究,以全面了解经颅磁刺激引起的大脑活动改变。
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Impact of repetitive transcranial magnetic stimulation on cortical activity: a systematic review and meta-analysis utilizing functional near-infrared spectroscopy evaluation.

Background: Repeated transcranial magnetic stimulation (rTMS) could induce alterations in cortical excitability and promote neuroplasticity. To precisely quantify these effects, functional near-infrared spectroscopy (fNIRS), an optical neuroimaging modality adept at detecting changes in cortical hemodynamic responses, has been employed concurrently alongside rTMS to measure and tailor the impact of diverse rTMS protocols on the brain cortex.

Objective: This systematic review and meta-analysis aimed to elucidate the effects of rTMS on cortical hemodynamic responses over the primary motor cortex (M1) as detected by fNIRS.

Methods: Original articles that utilized rTMS to stimulate the M1 cortex in combination with fNIRS for the assessment of cortical activity were systematically searched across the PubMed, Embase, and Scopus databases. The search encompassed records from the inception of these databases up until April, 2024. The assessment for risk of bias was also conducted. A meta-analysis was also conducted in studies with extractable raw data.

Results: Among 312 studies, 14 articles were eligible for qualitative review. 7 studies were eligible for meta-analysis. A variety of rTMS protocols was employed on M1 cortex. In inhibitory rTMS, multiple studies observed a reduction in the concentration of oxygenated hemoglobin [HbO] at the ipsilateral M1, contrasted by an elevation at the contralateral M1. Meta-analysis also corroborated this consistent trend. Nevertheless, certain investigations unveiled diminished [HbO] in bilateral M1. Several studies also depicted intricate inhibitory or excitatory interplay among distinct cortical regions.

Conclusion: Diverse rTMS protocols led to varied patterns of cortical activity detected by fNIRS. Meta-analysis revealed a trend of increasing [HbO] in the contralateral cortices and decreasing [HbO] in the ipsilateral cortices following low frequency inhibitory rTMS. However, due to the heterogeneity between studies, further research is necessary to comprehensively understand rTMS-induced alterations in brain activity.

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来源期刊
Journal of NeuroEngineering and Rehabilitation
Journal of NeuroEngineering and Rehabilitation 工程技术-工程:生物医学
CiteScore
9.60
自引率
3.90%
发文量
122
审稿时长
24 months
期刊介绍: Journal of NeuroEngineering and Rehabilitation considers manuscripts on all aspects of research that result from cross-fertilization of the fields of neuroscience, biomedical engineering, and physical medicine & rehabilitation.
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