一例食管胃交界处癌症患者通过胃造瘘术给美沙酮片剂控制疼痛

IF 2.2 3区 医学 Q2 HEALTH CARE SCIENCES & SERVICES Journal of palliative medicine Pub Date : 2024-12-01 Epub Date: 2024-06-25 DOI:10.1089/jpm.2024.0064
Ryusuke Ouchi, Hiroyuki Suzuki, Naoko Kurata, Takashi Watanabe, Munenori Nagao, Shinju Suzuki, Toshihiro Yamagata, Mie Chiba, Kensuke Usui, Yuriko Murai, Kaori Koyama, Kouji Okada
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引用次数: 0

摘要

导言:当其他阿片类镇痛药无效时,美沙酮可用于治疗顽固性癌痛。在胃肠道阻塞的情况下,美沙酮片剂可能难以服用。然而,改变美沙酮片剂的给药途径是可行的。病例描述:患者被诊断出患有食管胃交界处癌症并有多处转移,在无法继续口服药物后仍继续服用美沙酮片剂。治疗方法美沙酮片剂采用简单的混悬法经胃造瘘术给药。我们每天测量睡眠时的呼吸频率。我们还使用 12 导联心电图每周测量 QTc 值,并定期测量美沙酮的血液浓度。未观察到任何副作用。结论使用简单的悬浮方法给药美沙酮是一种安全的疼痛治疗方法,同时还需进行仔细监测。迄今为止,还没有研究探讨过美沙酮片剂的管给药安全性。因此,本病例报告具有重要的临床意义。
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A Case of Esophagogastric Junction Cancer Treated with Pain Control by Administering Methadone Tablets Through a Gastrostomy.

Introduction: Methadone is used to treat intractable cancer pain when other opioid analgesics are ineffective. Methadone tablets may be difficult to administer in cases of gastrointestinal passage obstruction. However, changing the route of methadone tablet administration is possible. Case Description: The patient, diagnosed with esophagogastric junction cancer with multiple metastases, continued to receive methadone tablets even after not being longer able to take oral medication. Method: Methadone tablets were administered using a simple suspension method via gastrostomy. We measured the respiratory rate during sleep daily. We also measured weekly QTc values using a 12-lead electrocardiogram and methadone blood concentration periodically. No side effects were observed. Conclusion: Using a simple suspension method to administer methadone is a safe pain management method when accompanied by careful monitoring. To date, no study has examined the tube administration safety of methadone tablets. Thus, this case report is of important clinical significance.

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来源期刊
Journal of palliative medicine
Journal of palliative medicine 医学-卫生保健
CiteScore
3.90
自引率
10.70%
发文量
345
审稿时长
2 months
期刊介绍: Journal of Palliative Medicine is the premier peer-reviewed journal covering medical, psychosocial, policy, and legal issues in end-of-life care and relief of suffering for patients with intractable pain. The Journal presents essential information for professionals in hospice/palliative medicine, focusing on improving quality of life for patients and their families, and the latest developments in drug and non-drug treatments. The companion biweekly eNewsletter, Briefings in Palliative Medicine, delivers the latest breaking news and information to keep clinicians and health care providers continuously updated.
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