{"title":"68Ga-pentixafor PET/CT 在原发性醛固酮增多症并发亚临床库欣综合征定位诊断中的应用：两个病例报告。","authors":"Xin Wei, Feifei Wu, Haoyu Dong, Ying Jing, Ying Song, Hua Pang, Jing Chen, Zhipeng Du, Wenwen He, Linqiang Ma, Yue Wang, Jinbo Hu, Qifu Li, Shumin Yang","doi":"10.1007/s12020-024-03865-6","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>Adrenal venous sampling (AVS) is recommended for subtyping primary aldosteronism (PA). However, in cases of PA, concurrent subclinical Cushing's syndrome (SCS) has the potential to confound AVS results. Pentixafor, a CXC chemokine receptor type 4-specific ligand, has been reported as a promising marker to evaluate functional nature of adrenal adenomas. This study aims to investigate the clinical value of Gallium-68 Pentixafor Positron Emission Tomography-Computed Tomography (<sup>68</sup>Ga-Pentixafor PET/CT) in the localization diagnosis of patients with PA plus SCS.</p><p><strong>Methods: </strong>Two patients with a confirmed diagnosis of PA plus SCS underwent AVS and <sup>68</sup>Ga-Pentixafor PET/CT.</p><p><strong>Results: </strong>AVS results revealed no lateralization for both patients while <sup>68</sup>Ga-Pentixafor PET/CT showed a unilateral adrenal nodule with increased uptake of <sup>68</sup>Ga-Pentixafor. Unilateral adrenalectomy was performed based on the results of <sup>68</sup>Ga-Pentixafor PET/CT. Subsequently, complete biochemical remission of autonomous aldosterone and cortisol secretion were achieved in both cases.</p><p><strong>Conclusions: </strong><sup>68</sup>Ga-Pentixafor PET/CT shows promising potential for the localization of aldosterone and cortisol co-secreting adrenal adenoma in patients with PA plus SCS.</p>","PeriodicalId":49211,"journal":{"name":"Endocrine","volume":null,"pages":null},"PeriodicalIF":3.0000,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"<sup>68</sup>Ga-pentixafor PET/CT in the localization diagnosis of primary aldosteronism concurrent subclinical cushing's syndrsome: two case reports.\",\"authors\":\"Xin Wei, Feifei Wu, Haoyu Dong, Ying Jing, Ying Song, Hua Pang, Jing Chen, Zhipeng Du, Wenwen He, Linqiang Ma, Yue Wang, Jinbo Hu, Qifu Li, Shumin Yang\",\"doi\":\"10.1007/s12020-024-03865-6\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>Adrenal venous sampling (AVS) is recommended for subtyping primary aldosteronism (PA). However, in cases of PA, concurrent subclinical Cushing's syndrome (SCS) has the potential to confound AVS results. Pentixafor, a CXC chemokine receptor type 4-specific ligand, has been reported as a promising marker to evaluate functional nature of adrenal adenomas. This study aims to investigate the clinical value of Gallium-68 Pentixafor Positron Emission Tomography-Computed Tomography (<sup>68</sup>Ga-Pentixafor PET/CT) in the localization diagnosis of patients with PA plus SCS.</p><p><strong>Methods: </strong>Two patients with a confirmed diagnosis of PA plus SCS underwent AVS and <sup>68</sup>Ga-Pentixafor PET/CT.</p><p><strong>Results: </strong>AVS results revealed no lateralization for both patients while <sup>68</sup>Ga-Pentixafor PET/CT showed a unilateral adrenal nodule with increased uptake of <sup>68</sup>Ga-Pentixafor. Unilateral adrenalectomy was performed based on the results of <sup>68</sup>Ga-Pentixafor PET/CT. Subsequently, complete biochemical remission of autonomous aldosterone and cortisol secretion were achieved in both cases.</p><p><strong>Conclusions: </strong><sup>68</sup>Ga-Pentixafor PET/CT shows promising potential for the localization of aldosterone and cortisol co-secreting adrenal adenoma in patients with PA plus SCS.</p>\",\"PeriodicalId\":49211,\"journal\":{\"name\":\"Endocrine\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.0000,\"publicationDate\":\"2024-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Endocrine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s12020-024-03865-6\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/6/24 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Endocrine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s12020-024-03865-6","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/6/24 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
引用次数: 0
摘要
目的：建议采用肾上腺静脉采样（AVS）对原发性醛固酮增多症（PA）进行亚型鉴定。然而，在 PA 病例中，并发亚临床库欣综合征（SCS）有可能混淆 AVS 的结果。据报道，CXC 趋化因子受体 4 型特异性配体 Pentixafor 是评估肾上腺腺瘤功能性质的一种有前途的标记物。本研究旨在探讨镓-68 Pentixafor 正电子发射断层扫描-计算机断层扫描（68Ga-Pentixafor PET/CT）在 PA 加 SCS 患者定位诊断中的临床价值：两名确诊为 PA 加 SCS 的患者接受了 AVS 和 68Ga-Pentixafor PET/CT 检查：结果：AVS结果显示两名患者均无侧位，而68Ga-Pentixafor PET/CT显示单侧肾上腺结节，68Ga-Pentixafor摄取量增加。根据 68Ga-Pentixafor PET/CT 的结果，对患者进行了单侧肾上腺切除术。随后，两个病例的自主醛固酮和皮质醇分泌均实现了完全生化缓解：68Ga-Pentixafor正电子发射计算机断层显像/计算机断层扫描在定位PA加SCS患者的醛固酮和皮质醇共分泌肾上腺腺瘤方面显示出良好的潜力。
68Ga-pentixafor PET/CT in the localization diagnosis of primary aldosteronism concurrent subclinical cushing's syndrsome: two case reports.
Purpose: Adrenal venous sampling (AVS) is recommended for subtyping primary aldosteronism (PA). However, in cases of PA, concurrent subclinical Cushing's syndrome (SCS) has the potential to confound AVS results. Pentixafor, a CXC chemokine receptor type 4-specific ligand, has been reported as a promising marker to evaluate functional nature of adrenal adenomas. This study aims to investigate the clinical value of Gallium-68 Pentixafor Positron Emission Tomography-Computed Tomography (68Ga-Pentixafor PET/CT) in the localization diagnosis of patients with PA plus SCS.
Methods: Two patients with a confirmed diagnosis of PA plus SCS underwent AVS and 68Ga-Pentixafor PET/CT.
Results: AVS results revealed no lateralization for both patients while 68Ga-Pentixafor PET/CT showed a unilateral adrenal nodule with increased uptake of 68Ga-Pentixafor. Unilateral adrenalectomy was performed based on the results of 68Ga-Pentixafor PET/CT. Subsequently, complete biochemical remission of autonomous aldosterone and cortisol secretion were achieved in both cases.
Conclusions: 68Ga-Pentixafor PET/CT shows promising potential for the localization of aldosterone and cortisol co-secreting adrenal adenoma in patients with PA plus SCS.
期刊介绍：
Well-established as a major journal in today’s rapidly advancing experimental and clinical research areas, Endocrine publishes original articles devoted to basic (including molecular, cellular and physiological studies), translational and clinical research in all the different fields of endocrinology and metabolism. Articles will be accepted based on peer-reviews, priority, and editorial decision. Invited reviews, mini-reviews and viewpoints on relevant pathophysiological and clinical topics, as well as Editorials on articles appearing in the Journal, are published. Unsolicited Editorials will be evaluated by the editorial team. Outcomes of scientific meetings, as well as guidelines and position statements, may be submitted. The Journal also considers special feature articles in the field of endocrine genetics and epigenetics, as well as articles devoted to novel methods and techniques in endocrinology.
Endocrine covers controversial, clinical endocrine issues. Meta-analyses on endocrine and metabolic topics are also accepted. Descriptions of single clinical cases and/or small patients studies are not published unless of exceptional interest. However, reports of novel imaging studies and endocrine side effects in single patients may be considered. Research letters and letters to the editor related or unrelated to recently published articles can be submitted.
Endocrine covers leading topics in endocrinology such as neuroendocrinology, pituitary and hypothalamic peptides, thyroid physiological and clinical aspects, bone and mineral metabolism and osteoporosis, obesity, lipid and energy metabolism and food intake control, insulin, Type 1 and Type 2 diabetes, hormones of male and female reproduction, adrenal diseases pediatric and geriatric endocrinology, endocrine hypertension and endocrine oncology.
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