母亲怀孕早期的体重指数与后代患睡眠呼吸暂停的风险。

IF 3.5 3区 医学 Q1 CLINICAL NEUROLOGY Journal of Clinical Sleep Medicine Pub Date : 2024-10-01 DOI:10.5664/jcsm.11228
Mia Q Zhu, Sven Cnattingius, Louise M O'Brien, Eduardo Villamor
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引用次数: 0

摘要

研究目的研究母亲孕早期体重指数(BMI)与后代睡眠呼吸暂停诊断之间的关系:我们对瑞典 3,281,803 名 1983-2015 年出生的单胎活产婴儿进行了全国性队列研究。我们利用具有前瞻性信息记录的国家登记册,对参与者进行了从 2 岁到 35 岁的睡眠呼吸暂停诊断跟踪。我们使用调整后的 Cox 模型中的危险比 (HR) 和 95% 置信区间 (CI),比较了不同孕早期 BMI 类别的睡眠呼吸暂停风险。为了解决家族内共有因素的干扰,我们进行了同胞对照分析,并研究了同胞母亲的 BMI 与指数后代睡眠呼吸暂停风险的关系:共有 17,830 例睡眠呼吸暂停诊断。与 BMI 值正常(18.5-24.9)的女性相比,母亲 BMI 值为 25.0-29.9(超重)的女性后代睡眠呼吸暂停的调整 HR 值(95% CI)高于母亲 BMI 值为 25.5-24.9(超重)的女性后代睡眠呼吸暂停的调整 HR 值(95% CI)。0-29.9(超重)、30.0-34.9(肥胖 I 级)和≥35.0(肥胖 II 级或 III 级)的后代睡眠呼吸暂停调整 HR(95% CI)分别为 1.14(1.09,1.19)、1.28(1.20,1.36)和 1.40(1.27,1.54)。根据同胞对照分析得出的相应 HR 分别为 1.13(1.01,1.26)、1.17(0.97,1.42)和 1.32(0.97,1.80)。兄弟姐妹的母体体重指数对死亡率的影响有所减弱,这表明共同的家族因素作用微弱。其他妊娠、分娩和新生儿并发症与后代睡眠呼吸暂停的风险有关,但并未在很大程度上介导与母亲肥胖的关联:结论:母体超重和肥胖与后代睡眠呼吸暂停的风险呈剂量反应关系。
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Maternal early pregnancy body mass index and risk of sleep apnea in the offspring.

Study objectives: We investigated the association between maternal early pregnancy body mass index (BMI) and offspring sleep apnea diagnosis.

Methods: We conducted a nationwide cohort study among 3,281,803 singleton live births in Sweden born 1983-2015. Using national registers with prospectively recorded information, we followed participants for a sleep apnea diagnosis from 2 to up to 35 years of age. We compared sleep apnea risks by early pregnancy BMI categories using hazard ratios with 95% confidence intervals from adjusted Cox models. To address confounding by factors shared within families, we conducted sibling-controlled analyses and studied the relation of siblings' maternal BMI with index offspring's sleep apnea risk.

Results: There were 17,830 sleep apnea diagnoses. Maternal early pregnancy BMI was positively associated with offspring sleep apnea risk; compared with women with normal BMI (18.5-24.9), adjusted hazard ratios (95% confidence intervals) of offspring sleep apnea for maternal BMI categories 25.0-29.9 (overweight), 30.0-34.9 (obesity class I), and ≥35.0 (obesity class II or III) were, respectively, 1.14 (1.09, 1.19), 1.28 (1.20, 1.36), and 1.40 (1.27, 1.54). Corresponding hazard ratios from sibling-controlled analyses representing risk change for maternal BMI differences between pregnancies were, respectively, 1.13 (1.01, 1.26), 1.17 (0.97, 1.42), and 1.32 (0.97, 1.80). Hazard ratios by siblings' maternal BMI were attenuated, suggesting a weak role for shared familial factors. Other pregnancy, birth, and neonatal complications were associated with offspring sleep apnea risk but did not substantially mediate the association with maternal obesity.

Conclusions: Maternal overweight and obesity are associated with offspring sleep apnea risk in a dose-response manner.

Citation: Zhu MQ, Cnattingius S, O'Brien LM, Villamor E. Maternal early pregnancy body mass index and risk of sleep apnea in the offspring. J Clin Sleep Med. 2024;20(10):1675-1684.

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来源期刊
CiteScore
6.20
自引率
7.00%
发文量
321
审稿时长
1 months
期刊介绍: Journal of Clinical Sleep Medicine focuses on clinical sleep medicine. Its emphasis is publication of papers with direct applicability and/or relevance to the clinical practice of sleep medicine. This includes clinical trials, clinical reviews, clinical commentary and debate, medical economic/practice perspectives, case series and novel/interesting case reports. In addition, the journal will publish proceedings from conferences, workshops and symposia sponsored by the American Academy of Sleep Medicine or other organizations related to improving the practice of sleep medicine.
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