Yifan Hong , Jiaqi Yang , Xinyuan Liu , Sicong Huang , Tingbo Liang , Xueli Bai
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引用次数: 0
摘要
胰腺导管腺癌（PDAC）常常在无法手术的晚期才被诊断出来，这给治疗带来了巨大挑战。因此，开发可靠的 PDAC 筛查工具对于有效预防和治疗至关重要。细胞外囊泡（EVs）的特点是其杯状脂质双层结构和从各种类型细胞中无处不在的释放，作为一种新兴的液体活检技术，它具有快速、微创、易于取样和成本效益高等显著优势。EV 在癌症进展中扮演着重要角色，而 EV 蛋白则是多种细胞行为的直接介质，作为 PDAC 诊断和预后的生物标记物具有巨大潜力。本综述概述了有关 PDAC 诊断和预后影响以及疾病进展的 EV 蛋白。
Deciphering extracellular vesicles protein cargo in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) presents a significant therapeutic challenge as it is frequently diagnosed at advanced inoperable stages. Therefore, the development of a reliable screening tool for PDAC is crucial for effective prevention and treatment. Extracellular vesicles (EVs), characterized by their cup-shaped lipid bilayer structure and ubiquitous release from various cell types, offer notable advantages as an emerging liquid biopsy technique that is rapid, minimally invasive, easily sampled, and cost-effective. While EVs play a substantial role in cancer progression, EV proteins serve as direct mediators of diverse cellular behaviors and have immense potential as biomarkers for PDAC diagnosis and prognostication. This review provides an overview of EV proteins regarding PDAC diagnosis and prognostic implications as well as disease progression.
期刊介绍：
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer encompasses the entirety of cancer biology and biochemistry, emphasizing oncogenes and tumor suppressor genes, growth-related cell cycle control signaling, carcinogenesis mechanisms, cell transformation, immunologic control mechanisms, genetics of human (mammalian) cancer, control of cell proliferation, genetic and molecular control of organismic development, rational anti-tumor drug design. It publishes mini-reviews and full reviews.
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