还原石墨烯氧化物活化的 TiO2/UHMWPE 复合材料在白光下的光生物杀灭活性

IF 9.6 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY Nano Letters Pub Date : 2024-06-25 DOI:10.1021/acs.nanolett.4c00939

Sang Bin Jeong, Ki Joon Heo, Jae Hyun Yoo, Dong-Gi Kang, Leonardo Santoni, Caroline E. Knapp, Andreas Kafizas, Claire J. Carmalt, Ivan P. Parkin, Jae Hak Shin, Gi Byoung Hwang, Jae Hee Jung

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引用次数: 0

摘要

在此，我们介绍一种由白光激活的光生物杀灭表面。这种光生物杀灭表面是通过热压二氧化钛（TiO2）、超高分子量聚乙烯（UHMWPE）和还原氧化石墨烯（rGO）粉末的混合物制成的。在超高分子量聚乙烯-二氧化钛上没有观察到光生物杀灭活性。然而，UHMWPE-TiO2@rGO 在白光照射 12 小时后，对表皮葡萄球菌和大肠杆菌表现出强大的杀光活性（降低 3 个菌落）。对噬菌体 phi 6 病毒（SARS-CoV-2 的代用品）的活性更强，在白光下照射 6 小时后，可降低 5 个菌落。我们的机理研究表明，UHMWPE-TiO2@rGO 只被紫外线激活，紫外线占白光 LED 灯发出的光的 0.31%，产生的活性氧对微生物是致命的。这表明，在超高分子量聚乙烯-二氧化钛中加入 rGO 后，即使在较浅的紫外线通量水平下也能引发强烈的杀光活性。

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Photobiocidal Activity of TiO2/UHMWPE Composite Activated by Reduced Graphene Oxide under White Light

Herein, we introduce a photobiocidal surface activated by white light. The photobiocidal surface was produced through thermocompressing a mixture of titanium dioxide (TiO₂), ultra-high-molecular-weight polyethylene (UHMWPE), and reduced graphene oxide (rGO) powders. A photobiocidal activity was not observed on UHMWPE-TiO₂. However, UHMWPE-TiO₂@rGO exhibited potent photobiocidal activity (>3-log reduction) against Staphylococcus epidermidis and Escherichia coli bacteria after a 12 h exposure to white light. The activity was even more potent against the phage phi 6 virus, a SARS-CoV-2 surrogate, with a >5-log reduction after 6 h exposure to white light. Our mechanistic studies showed that the UHMWPE-TiO₂@rGO was activated only by UV light, which accounts for 0.31% of the light emitted by the white LED lamp, producing reactive oxygen species that are lethal to microbes. This indicates that adding rGO to UHMWPE-TiO₂ triggered intense photobiocidal activity even at shallow UV flux levels.

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来源期刊

Nano Letters 工程技术-材料科学：综合

CiteScore

16.80

自引率

2.80%

发文量

1182

审稿时长

1.4 months

期刊介绍： Nano Letters serves as a dynamic platform for promptly disseminating original results in fundamental, applied, and emerging research across all facets of nanoscience and nanotechnology. A pivotal criterion for inclusion within Nano Letters is the convergence of at least two different areas or disciplines, ensuring a rich interdisciplinary scope. The journal is dedicated to fostering exploration in diverse areas, including: - Experimental and theoretical findings on physical, chemical, and biological phenomena at the nanoscale - Synthesis, characterization, and processing of organic, inorganic, polymer, and hybrid nanomaterials through physical, chemical, and biological methodologies - Modeling and simulation of synthetic, assembly, and interaction processes - Realization of integrated nanostructures and nano-engineered devices exhibiting advanced performance - Applications of nanoscale materials in living and environmental systems Nano Letters is committed to advancing and showcasing groundbreaking research that intersects various domains, fostering innovation and collaboration in the ever-evolving field of nanoscience and nanotechnology.