利用硅学技术将二甲双胍重新用作潜在的抗癌药物。

IF 2.5 4区 医学 Q3 PHARMACOLOGY & PHARMACY DARU Journal of Pharmaceutical Sciences Pub Date : 2024-12-01 Epub Date: 2024-06-26 DOI:10.1007/s40199-024-00523-0
Mona Mahfauz, Ozel Yuruker, Rasime Kalkan
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引用次数: 0

摘要

背景:近来,人们越来越关注将现成的知名药物重新用于新的创造性用途。二甲双胍就是这样一种药物,它是一种常用于控制糖尿病的药物,其使用与降低癌症发病率和死亡率之间存在良好的相关性。根据这一结论,人们进行了大量调查和临床试验,以评估二甲双胍作为抗癌药物的应用可能性:本研究使用 "通路/基因组分析 "Gene2drug、基因本体(GO)资源和DepMap来确定二甲双胍是否对治疗癌症有潜在优势:方法:使用药物敏感性(初筛)19Q4 工具分析了 1826 个肿瘤细胞系:结果:在1826个肿瘤细胞系的402个基因中,SGPL1、CXCR6、ATXN2L、LAMP3、RTN3、BTN2A1、FOXM1、NQO1和L1TD1等9个基因对二甲双胍表现出统计学敏感性:该研究显示了特定癌细胞株对二甲双胍的敏感性。因此,二甲双胍和肿瘤靶向治疗策略大有可为。不过,建议对二甲双胍的潜在有效性和作用机制进行进一步研究。
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Repurposing metformin as a potential anticancer agent using in silico technique.

Background: The focus on repurposing readily available, well-known drugs for new, creative uses has grown recently. One such medication is metformin, a drug commonly used to manage diabetes, which shows a favorable correlation between its use and lower cancer morbidity and death. Numerous investigations and clinical trials have been conducted to evaluate the possible application of metformin as an anticancer medication in light of this conclusion.

Objective: This study used 'pathway/gene-set analysis' Gene2drug, a resource for Gene Ontology (GO), and DepMap to determine whether metformin would be potentially advantageous for treating cancer.

Methods: A total of 1826 tumor cell lines were analyzed using the Drug Sensitivity (Primary Purposing Primary Screening) 19Q4 Tool.

Results: 9 genes from 402 genes, SGPL1, CXCR6, ATXN2L, LAMP3, RTN3, BTN2A1, FOXM1, NQO1, and L1TD1 in 1826 cancer cell line showed statistical sensitivity to metformin.

Conclusion: This in-silico study showed the sensitivity of specific cancer cell lines to metformin. Therefore, holding promises for metformin and tumor-targeted treatment strategies. It is recommended, however, to conduct further research into its potential effectiveness and mechanism of action.

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DARU Journal of Pharmaceutical Sciences
DARU Journal of Pharmaceutical Sciences PHARMACOLOGY & PHARMACY-
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期刊介绍: DARU Journal of Pharmaceutical Sciences is a peer-reviewed journal published on behalf of Tehran University of Medical Sciences. The journal encompasses all fields of the pharmaceutical sciences and presents timely research on all areas of drug conception, design, manufacture, classification and assessment. The term DARU is derived from the Persian name meaning drug or medicine. This journal is a unique platform to improve the knowledge of researchers and scientists by publishing novel articles including basic and clinical investigations from members of the global scientific community in the forms of original articles, systematic or narrative reviews, meta-analyses, letters, and short communications.
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