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引用次数: 0
摘要
肾脏在新陈代谢和排泄方面发挥着不可替代的作用。然而，由于局部药物浓度过高、炎症和创伤等原因，急性肾损伤（AKI）经常发生。具有优异检测性能的活化光学探针可在 AKI 初期有效识别生物标记物，在评估 AKI 和预防疾病发展方面发挥重要作用。本文总结了具有代表性的分子探针设计策略和特殊诊断应用。这些分子探针在基础研究和临床诊断方面显示出巨大的潜力，可增强组织结构和生物标志物的图像，并能对 AKI 进行早期诊断。此外，本文还讨论了光学探针在 AKI 开发和应用中可能面临的困难和挑战。
Optical Molecular Probes for Imaging and Early Diagnosis of Acute Kidney Injury.
The kidneys play an irreplaceable role in metabolism and excretion. However, Acute Kidney Injury (AKI) often occurs due to high local concentrations of drugs, inflammation, and trauma. Activated optical probes with excellent detection performance can effectively identify biomarkers in the initial stage of AKI and play an important role in evaluating AKI and preventing the development of diseases. This article summarizes representative design strategies for molecular probes and special diagnostic applications. These molecular probes show great potential in basic research and clinical diagnosis, enabling enhanced images of tissue structure and biomarkers, as well as early diagnosis of AKI. In addition, the difficulties and challenges that optical probes may face in the development and application of AKI are also discussed in this article.
期刊介绍：
Aims & Scope
Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews and guest edited thematic issues written by leaders in the field covering a range of the current topics in medicinal chemistry. The journal also publishes reviews on recent patents. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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