蛋白酪氨酸磷酸酶抑制剂:专利回顾与更新(2012-2023 年)。

IF 5.4 2区 医学 Q1 CHEMISTRY, MEDICINAL Expert Opinion on Therapeutic Patents Pub Date : 2024-04-01 Epub Date: 2024-06-19 DOI:10.1080/13543776.2024.2362203
Lakshmi Mounika Kelam, Vaishnavi Chhabra, Sarika Dhiman, Deevena Kumari, M Elizabeth Sobhia
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引用次数: 0

摘要

导言:蛋白酪氨酸磷酸酶(PTPs)是一种重要的、在进化过程中高度保守的酶,通过调节酪氨酸磷酸化这一信号转导的关键翻译后修饰来控制细胞功能。最近在磷酸酶药物发现方面取得了长足进步,从而确定了酶的选择性调节剂,恢复了对蛋白磷酸酶靶向治疗的兴趣:截至 2023 年的专利汇编侧重于各类酪氨酸磷酸酶及其抑制剂的功效,详细介绍了它们的化学结构和生化特性。这些发现具有广泛的意义,因为它们可用于治疗癌症、糖尿病、自身免疫性疾病和神经系统疾病等多种疾病。我们利用知名的不同平台对科学文章和专利文献进行了搜索,以收集截至 2023 年的信息:蛋白酪氨酸磷酸酶(PTP)研究的最新进展包括发现了针对特定 PTP 酶的新型抑制剂,重点是开发异位位点共价抑制剂,以提高疗效和特异性。这些进展不仅为各种疾病的治疗干预开辟了新的可能性,而且还为创新治疗带来了潜力。PTP 为药物发现工作和各种健康状况的创新治疗提供了前景广阔的途径。
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Protein tyrosine phosphatase inhibitors: a patent review and update (2012-2023).

Introduction: Protein tyrosine phosphatases (PTPs), essential and evolutionarily highly conserved enzymes, govern cellular functions by modulating tyrosine phosphorylation, a pivotal post-translational modification for signal transduction. The recent strides in phosphatase drug discovery, leading to the identification of selective modulators for enzymes, restoring interest in the therapeutic targeting of protein phosphatases.

Areas covered: The compilation of patents up to the year 2023 focuses on the efficacy of various classes of Tyrosine phosphatases and their inhibitors, detailing their chemical structure and biochemical characteristics. These findings have broad implications, as they can be applied to treating diverse conditions like cancer, diabetes, autoimmune disorders, and neurological diseases. The search for scientific articles and patent literature was conducted using well known different platforms to gather information up to 2023.

Expert opinion: The latest improvements in protein tyrosine phosphatase (PTP) research include the discovery of new inhibitors targeting specific PTP enzymes, with a focus on developing allosteric site covalent inhibitors for enhanced efficacy and specificity. These advancements have not only opened up new possibilities for therapeutic interventions in various disease conditions but also hold the potential for innovative treatments. PTPs offer promising avenues for drug discovery efforts and innovative treatments across a spectrum of health conditions.

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来源期刊
CiteScore
12.10
自引率
1.50%
发文量
50
审稿时长
6-12 weeks
期刊介绍: Expert Opinion on Therapeutic Patents (ISSN 1354-3776 [print], 1744-7674 [electronic]) is a MEDLINE-indexed, peer-reviewed, international journal publishing review articles on recent pharmaceutical patent claims, providing expert opinion the scope for future development, in the context of the scientific literature. The Editors welcome: Reviews covering recent patent claims on compounds or applications with therapeutic potential, including biotherapeutics and small-molecule agents with specific molecular targets; and patenting trends in a particular therapeutic area Patent Evaluations examining the aims and chemical and biological claims of individual patents Perspectives on issues relating to intellectual property The audience consists of scientists, managers and decision-makers in the pharmaceutical industry and others closely involved in R&D Sample our Bioscience journals, sign in here to start your access, Latest two full volumes FREE to you for 14 days.
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