Kan Zhang MM, Ying Sun MD, Jiancao Ding MM, Qing Ma MD, Dai Zhang MM, Wei Huang MM, Yunli Xing MD
{"title":"营养状况对老年非瓣膜性心房颤动患者不良临床事件的影响：一项回顾性队列研究。","authors":"Kan Zhang MM, Ying Sun MD, Jiancao Ding MM, Qing Ma MD, Dai Zhang MM, Wei Huang MM, Yunli Xing MD","doi":"10.1111/anec.13130","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Objective</h3>\n \n <p>To explore the influence of nutritional status on adverse clinical events in elderly patients with nonvalvular atrial fibrillation.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>This retrospective observational cohort study included 196 patients, 75–102-years-old, with nonvalvular atrial fibrillation, hospitalized in our hospital. The nutritional status was assessed using Mini-Nutritional Assessment—Short Form (MNA-SF). Patients with MNA-SF scores of 0–11 and 12–14 were included in the malnutrition and nonmalnutrition groups, respectively.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>The average age of the malnutrition group was higher than that of the nonmalnutrition group, and the levels of body mass index (BMI), hemoglobin (HGB), and albumin (ALB) were significantly lower than those of the nonmalnutrition group, with statistical significance (<i>p</i> < .05). The incidence of all-cause death in the malnutrition group was higher than that in the nonmalnutrition group (<i>p</i> = .007). Kaplan–Meier curve indicated that malnutrition patients have a higher risk of all-cause death (log-rank test, <i>p</i> = .001) and major bleeding events (<i>p</i> = .017). Multivariate Cox proportional hazard regression analysis corrected for confounders showed that malnutrition was an independent risk factor of all-cause death (HR = 1.780, 95%CI:1.039–3.050, <i>p</i> = .036). The malnutrition group had a significantly high incidence of major bleeding than the nonmalnutrition group (<i>p</i> = .026), and there was no significant difference in the proportion of anticoagulation therapy (<i>p</i> = .082) and the incidence of ischemic stroke/systemic embolism (<i>p</i> = .310) between the two groups.</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>Malnutrition is an independent risk factor of all-cause death in elderly patients with atrial fibrillation. The incidence of major bleeding in malnourished elderly patients with atrial fibrillation is high, and the benefit of anticoagulation therapy is not obvious.</p>\n </section>\n </div>","PeriodicalId":8074,"journal":{"name":"Annals of Noninvasive Electrocardiology","volume":"29 4","pages":""},"PeriodicalIF":1.1000,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11208721/pdf/","citationCount":"0","resultStr":"{\"title\":\"Effect of nutritional status on adverse clinical events in elderly patients with nonvalvular atrial fibrillation: A retrospective cohort study\",\"authors\":\"Kan Zhang MM, Ying Sun MD, Jiancao Ding MM, Qing Ma MD, Dai Zhang MM, Wei Huang MM, Yunli Xing MD\",\"doi\":\"10.1111/anec.13130\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Objective</h3>\\n \\n <p>To explore the influence of nutritional status on adverse clinical events in elderly patients with nonvalvular atrial fibrillation.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>This retrospective observational cohort study included 196 patients, 75–102-years-old, with nonvalvular atrial fibrillation, hospitalized in our hospital. The nutritional status was assessed using Mini-Nutritional Assessment—Short Form (MNA-SF). Patients with MNA-SF scores of 0–11 and 12–14 were included in the malnutrition and nonmalnutrition groups, respectively.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>The average age of the malnutrition group was higher than that of the nonmalnutrition group, and the levels of body mass index (BMI), hemoglobin (HGB), and albumin (ALB) were significantly lower than those of the nonmalnutrition group, with statistical significance (<i>p</i> < .05). The incidence of all-cause death in the malnutrition group was higher than that in the nonmalnutrition group (<i>p</i> = .007). Kaplan–Meier curve indicated that malnutrition patients have a higher risk of all-cause death (log-rank test, <i>p</i> = .001) and major bleeding events (<i>p</i> = .017). Multivariate Cox proportional hazard regression analysis corrected for confounders showed that malnutrition was an independent risk factor of all-cause death (HR = 1.780, 95%CI:1.039–3.050, <i>p</i> = .036). The malnutrition group had a significantly high incidence of major bleeding than the nonmalnutrition group (<i>p</i> = .026), and there was no significant difference in the proportion of anticoagulation therapy (<i>p</i> = .082) and the incidence of ischemic stroke/systemic embolism (<i>p</i> = .310) between the two groups.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusions</h3>\\n \\n <p>Malnutrition is an independent risk factor of all-cause death in elderly patients with atrial fibrillation. 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Effect of nutritional status on adverse clinical events in elderly patients with nonvalvular atrial fibrillation: A retrospective cohort study
Objective
To explore the influence of nutritional status on adverse clinical events in elderly patients with nonvalvular atrial fibrillation.
Methods
This retrospective observational cohort study included 196 patients, 75–102-years-old, with nonvalvular atrial fibrillation, hospitalized in our hospital. The nutritional status was assessed using Mini-Nutritional Assessment—Short Form (MNA-SF). Patients with MNA-SF scores of 0–11 and 12–14 were included in the malnutrition and nonmalnutrition groups, respectively.
Results
The average age of the malnutrition group was higher than that of the nonmalnutrition group, and the levels of body mass index (BMI), hemoglobin (HGB), and albumin (ALB) were significantly lower than those of the nonmalnutrition group, with statistical significance (p < .05). The incidence of all-cause death in the malnutrition group was higher than that in the nonmalnutrition group (p = .007). Kaplan–Meier curve indicated that malnutrition patients have a higher risk of all-cause death (log-rank test, p = .001) and major bleeding events (p = .017). Multivariate Cox proportional hazard regression analysis corrected for confounders showed that malnutrition was an independent risk factor of all-cause death (HR = 1.780, 95%CI:1.039–3.050, p = .036). The malnutrition group had a significantly high incidence of major bleeding than the nonmalnutrition group (p = .026), and there was no significant difference in the proportion of anticoagulation therapy (p = .082) and the incidence of ischemic stroke/systemic embolism (p = .310) between the two groups.
Conclusions
Malnutrition is an independent risk factor of all-cause death in elderly patients with atrial fibrillation. The incidence of major bleeding in malnourished elderly patients with atrial fibrillation is high, and the benefit of anticoagulation therapy is not obvious.
期刊介绍：
The ANNALS OF NONINVASIVE ELECTROCARDIOLOGY (A.N.E) is an online only journal that incorporates ongoing advances in the clinical application and technology of traditional and new ECG-based techniques in the diagnosis and treatment of cardiac patients.
ANE is the first journal in an evolving subspecialty that incorporates ongoing advances in the clinical application and technology of traditional and new ECG-based techniques in the diagnosis and treatment of cardiac patients. The publication includes topics related to 12-lead, exercise and high-resolution electrocardiography, arrhythmias, ischemia, repolarization phenomena, heart rate variability, circadian rhythms, bioengineering technology, signal-averaged ECGs, T-wave alternans and automatic external defibrillation.
ANE publishes peer-reviewed articles of interest to clinicians and researchers in the field of noninvasive electrocardiology. Original research, clinical studies, state-of-the-art reviews, case reports, technical notes, and letters to the editors will be published to meet future demands in this field.
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