Sissel B T Sørensen, Dóra K Farkas, Christian Vestergaard, Sigrun A J Schmidt, Lise Maria Lindahl, Kathryn E Mansfield, Sinead M Langan, Henrik T Sørensen
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In a cross-sectional analysis, we examined whether the extent of cancer spread differed between people with vs. without a previous urticaria diagnosis.</p><p><strong>Results: </strong>The overall SIR for all types of cancer was 1.09 (95% CI 1.06-1.11) based on 7788 observed vs. 7161 expected cases. The risk for any cancer was 0.7% (95% CI 0.6-0.7) for the first year of follow-up. Cancer was diagnosed in 588 people with urticaria during the first year of follow-up (SIR 1.49, 95% CI 1.38-1.62) and in 7200 people thereafter (SIR 1.06, 95% CI 1.04-1.09). During the first year of follow-up, we found strong associations with haematological cancers (e.g. non-Hodgkin lymphoma; SIR 2.91, 95% CI 1.92-4.23). Cancer stage was similar in people with vs. without a previous urticaria diagnosis.</p><p><strong>Conclusions: </strong>At the time of urticaria diagnosis, or in the first year afterward, we found a large increase in the risk of cancer. In subsequent years, a persistent 6% increase in risk remained. Diagnostic efforts may partly explain the elevated short-term risk, but occult cancer may promote urticaria, or cancer and urticaria share common risk factors.</p>","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":null,"pages":null},"PeriodicalIF":11.0000,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Urticaria and the risk of cancer: a Danish population-based cohort study.\",\"authors\":\"Sissel B T Sørensen, Dóra K Farkas, Christian Vestergaard, Sigrun A J Schmidt, Lise Maria Lindahl, Kathryn E Mansfield, Sinead M Langan, Henrik T Sørensen\",\"doi\":\"10.1093/bjd/ljae264\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Urticaria has been tentatively linked to cancer, but epidemiological evidence supporting this link is sparse and conflicting. We conducted a population-based cohort study using healthcare databases covering the Danish population (January 1980-December 2022). We followed 87 507 people for a median of 10.1 years after their first hospital contact for urticaria.</p><p><strong>Objectives: </strong>To examine associations of a hospital diagnosis of urticaria with incident cancer.</p><p><strong>Methods: </strong>We computed the absolute risk of cancer and standardized incidence ratios (SIRs) with 95% confidence intervals (CIs) standardized to Danish national cancer rates. In a cross-sectional analysis, we examined whether the extent of cancer spread differed between people with vs. without a previous urticaria diagnosis.</p><p><strong>Results: </strong>The overall SIR for all types of cancer was 1.09 (95% CI 1.06-1.11) based on 7788 observed vs. 7161 expected cases. The risk for any cancer was 0.7% (95% CI 0.6-0.7) for the first year of follow-up. Cancer was diagnosed in 588 people with urticaria during the first year of follow-up (SIR 1.49, 95% CI 1.38-1.62) and in 7200 people thereafter (SIR 1.06, 95% CI 1.04-1.09). During the first year of follow-up, we found strong associations with haematological cancers (e.g. non-Hodgkin lymphoma; SIR 2.91, 95% CI 1.92-4.23). Cancer stage was similar in people with vs. without a previous urticaria diagnosis.</p><p><strong>Conclusions: </strong>At the time of urticaria diagnosis, or in the first year afterward, we found a large increase in the risk of cancer. In subsequent years, a persistent 6% increase in risk remained. Diagnostic efforts may partly explain the elevated short-term risk, but occult cancer may promote urticaria, or cancer and urticaria share common risk factors.</p>\",\"PeriodicalId\":9238,\"journal\":{\"name\":\"British Journal of Dermatology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":11.0000,\"publicationDate\":\"2024-10-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"British Journal of Dermatology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1093/bjd/ljae264\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"DERMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"British Journal of Dermatology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1093/bjd/ljae264","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"DERMATOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
背景:荨麻疹与癌症有初步联系,但支持这种联系的流行病学证据很少,而且相互矛盾。因此,我们利用丹麦人口的医疗保健数据库(1980 年 1 月至 2022 年 12 月)开展了一项基于人口的队列研究。我们对 87,507 名首次因荨麻疹住院的患者进行了中位数为 10.1 年的跟踪调查:研究荨麻疹的医院诊断与癌症发病率之间的关系:我们计算了癌症的绝对风险和标准化发病率比 (SIR),并根据丹麦全国癌症发病率标准化了 95% 置信区间 (CI)。在一项横断面分析中,我们研究了既往确诊过荨麻疹与未确诊过荨麻疹的人群的癌症扩散程度是否存在差异:根据 7788 例观察病例和 7161 例预期病例,所有类型癌症的总体 SIR 为 1.09(95% CI,1.06-1.11)。在随访的第一年中,罹患任何癌症的风险为 0.7%(95% CI,0.6-0.7)。在随访的第一年中,588 名荨麻疹患者被确诊为癌症(SIR 为 1.49,95% CI 为 1.38-1.62),之后的 7200 人被确诊为癌症(SIR 为 1.06,95% CI 为 1.04-1.09)。在第一年的随访中,我们发现了与血液癌症的密切联系(例如,非霍奇金淋巴瘤的 SIR 为 2.91,95% CI 为 1.92-4.23)。曾诊断出荨麻疹与未诊断出荨麻疹的患者的癌症分期相似:结论:在荨麻疹确诊时或确诊后的第一年,我们发现患癌症的风险大幅增加。在随后的几年中,患癌风险仍持续增加 6%。诊断工作可能是短期风险升高的部分原因,但隐性癌症可能会促进荨麻疹的发生,或者癌症和荨麻疹有共同的风险因素。
Urticaria and the risk of cancer: a Danish population-based cohort study.
Background: Urticaria has been tentatively linked to cancer, but epidemiological evidence supporting this link is sparse and conflicting. We conducted a population-based cohort study using healthcare databases covering the Danish population (January 1980-December 2022). We followed 87 507 people for a median of 10.1 years after their first hospital contact for urticaria.
Objectives: To examine associations of a hospital diagnosis of urticaria with incident cancer.
Methods: We computed the absolute risk of cancer and standardized incidence ratios (SIRs) with 95% confidence intervals (CIs) standardized to Danish national cancer rates. In a cross-sectional analysis, we examined whether the extent of cancer spread differed between people with vs. without a previous urticaria diagnosis.
Results: The overall SIR for all types of cancer was 1.09 (95% CI 1.06-1.11) based on 7788 observed vs. 7161 expected cases. The risk for any cancer was 0.7% (95% CI 0.6-0.7) for the first year of follow-up. Cancer was diagnosed in 588 people with urticaria during the first year of follow-up (SIR 1.49, 95% CI 1.38-1.62) and in 7200 people thereafter (SIR 1.06, 95% CI 1.04-1.09). During the first year of follow-up, we found strong associations with haematological cancers (e.g. non-Hodgkin lymphoma; SIR 2.91, 95% CI 1.92-4.23). Cancer stage was similar in people with vs. without a previous urticaria diagnosis.
Conclusions: At the time of urticaria diagnosis, or in the first year afterward, we found a large increase in the risk of cancer. In subsequent years, a persistent 6% increase in risk remained. Diagnostic efforts may partly explain the elevated short-term risk, but occult cancer may promote urticaria, or cancer and urticaria share common risk factors.
期刊介绍:
The British Journal of Dermatology (BJD) is committed to publishing the highest quality dermatological research. Through its publications, the journal seeks to advance the understanding, management, and treatment of skin diseases, ultimately aiming to improve patient outcomes.