IL18 rs360717 和 rs187238 基因变异与偏头痛诊断有关。

IF 3.5 2区医学 Q1 ANESTHESIOLOGY European Journal of Pain Pub Date : 2024-06-23 DOI:10.1002/ejp.2302

Aline Vitali-Silva, Valéria Aparecida Bello, Regina Célia Poli, Carlos Eduardo Coral de Oliveira, Milene Valéria Lopes, Diogo Nabhan Silveira, Beatriz Bagatim Bossa, Beatriz Rabello Espinosa, Tainah Mendes Ahrens, Edna Maria Vissoci Reiche, Andréa Name Colado Simão

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引用次数: 0

摘要

背景：偏头痛是一种由基因决定的疾病，易导致反复发作的头痛。白细胞介素（IL）-18是一种促炎症细胞因子，似乎在偏头痛的病理生理学中起作用，其基因变异可能会影响偏头痛的易感性：研究 IL18 rs360717 和 rs187238 基因变异与偏头痛诊断及其临床特征之间的关系：方法：对 152 名偏头痛患者和 155 名健康对照者进行了病例对照研究。研究收集了偏头痛的临床特征，以及有关偏头痛的残疾和影响、是否存在异感症、焦虑、抑郁和听觉障碍的有效问卷。采用实时聚合酶链反应（qPCR）和TaqMan™方法对IL18 rs360717和rs187238变体进行了基因分型：结果：IL18 rs360717A和rs187238G等位基因与偏头痛确诊几率增加有关（OR=1.53，95%CI 1.05-2.24，p=0.028；OR=1.46，95%CI 1.00-2.14，p=0.049）。在显性模型中，rs360717GA + AA 基因型也比 GG 基因型与更高的偏头痛几率相关（OR = 1.69，95%CI 1.05-2.73，p = 0.030）。在女性中，除了之前的关联外，在共显性模型和显性模型中，变异体也对偏头痛的发生几率有影响。此外，在女性中，rs360717GA + AA（OR = 3.04，95%CI 1.10-8.42，p = 0.032）和rs187238CG + GG（OR = 2.97，95%CI 1.08-8.21，p = 0.035）对偏头痛后感知的发生率有影响：结论：IL18 rs360717 和 rs187238 变体与偏头痛诊断和偏头痛后症状有关，尤其是在女性中：本研究表明，IL18 rs360717 和 rs187238 变体在偏头痛中起作用，影响偏头痛的诊断几率，尤其是女性偏头痛患者。IL18变体有望被视为偏头痛的潜在遗传生物标志物。

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IL18 rs360717 and rs187238 genetic variants are associated with migraine diagnosis

Background

Migraine is a genetically determined disorder that predisposes to recurrent episodes of headache. Interleukin (IL)-18 is a pro-inflammatory cytokine that seems to play a role in migraine pathophysiology, and its genetic variants could potentially impact susceptibility to migraine.

Objective

To investigate the association between IL18 rs360717 and rs187238 genetic variants with migraine diagnosis and its clinical characteristics.

Methods

A case-control study was conducted with 152 people with migraine and 155 healthy controls, matched by sex, age, ethnicity, and body mass index. Clinical characteristics of migraine, as well as validated questionnaires regarding disability and impact of migraine, presence of allodynia, anxiety, depression, and hyperacusis were collected. Genotyping for IL18 rs360717 and rs187238 variants was performed using real-time polymerase chain reaction (qPCR) and TaqMan™ method.

Results

The IL18 rs360717A and rs187238G alleles were associated with increased chance of being diagnosed with migraine (OR = 1.53, 95%CI 1.05–2.24, p = 0.028 and OR = 1.46, 95%CI 1.00–2.14, p = 0.049, respectively). In the dominant model, the rs360717GA + AA genotypes were also associated with a higher chance of migraine than the GG genotype (OR = 1.69, 95%CI 1.05–2.73, p = 0.030). In women, in addition to the previous associations, there was also an effect of the variants on the chance of migraine in the codominant models and dominant models. Furthermore, among women, there was an influence on the prevalence of postdrome perception with rs360717GA + AA (OR = 3.04, 95%CI 1.10–8.42, p = 0.032) and rs187238CG + GG (OR = 2.97, 95%CI 1.08–8.21, p = 0.035).

Conclusion

IL18 rs360717 and rs187238 variants were associated with migraine diagnosis and postdrome symptoms, especially in women.

Significance

This study has demonstrated that IL18 rs360717 and rs187238 variants play a role in migraine, influencing the chance of being diagnosed with migraine, particularly among women. There are prospects that IL18 variants could be considered potential genetic biomarkers for migraine.

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来源期刊

European Journal of Pain 医学-临床神经学

CiteScore

7.50

自引率

5.60%

发文量

163

审稿时长

4-8 weeks

期刊介绍： European Journal of Pain (EJP) publishes clinical and basic science research papers relevant to all aspects of pain and its management, including specialties such as anaesthesia, dentistry, neurology and neurosurgery, orthopaedics, palliative care, pharmacology, physiology, psychiatry, psychology and rehabilitation; socio-economic aspects of pain are also covered. Regular sections in the journal are as follows: • Editorials and Commentaries • Position Papers and Guidelines • Reviews • Original Articles • Letters • Bookshelf The journal particularly welcomes clinical trials, which are published on an occasional basis. Research articles are published under the following subject headings: • Neurobiology • Neurology • Experimental Pharmacology • Clinical Pharmacology • Psychology • Behavioural Therapy • Epidemiology • Cancer Pain • Acute Pain • Clinical Trials.