Katherine Nguyen, Diana M. Perriman, Jennie M. Scarvell, Mark R. Pickering, Catherine R. Galvin, Paul N. Smith, Joseph T. Lynch
{"title":"形状建模揭示了无症状膝关节中与年龄相关的膝关节骨骼形状变化。","authors":"Katherine Nguyen, Diana M. Perriman, Jennie M. Scarvell, Mark R. Pickering, Catherine R. Galvin, Paul N. Smith, Joseph T. Lynch","doi":"10.1002/jor.25923","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n <p>Osteoarthritis (OA) causes bony shape changes within the knee. Furthermore, the risk of developing OA increases with age. However, age alone does not cause OA. It is therefore important to understand the healthy age-related trajectories of knee shape before attributing these changes to OA. The aim of this study was to determine the association between bony knee shape and age using statistical-shape modelling (SSM). 96 participants received a CT scan of their knee. Three-dimensional models were created using manual segmentation. Separate SSM's for the distal femur and proximal tibia were created. Linear regression models were used to assess the association between age and femoral and tibial shape. Fourteen modes of the femoral and tibial SSM's captured 68% and 73% shape variation, respectively. Only femoral mode 3 and tibial mode 7 were associated with age. Increasing age was related to larger femoral bone volume and deepening of the femoral trochlear groove. Furthermore, increased age was associated with medial tibial plateau expansion. Aspects of bony femoral and tibial shape were significantly associated with aging, including femoral and tibial bone size, femoral trochlear groove, and medial tibial plateau area. Changes in knee morphology occur as a normal process of aging without osteoarthritis development. This may be a response to mechanical loading over time<i>.</i> Further research investigating the effect of these changes on loading in the knee may provide valuable information for knee health in older age.</p>\n </section>\n </div>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":null,"pages":null},"PeriodicalIF":2.1000,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jor.25923","citationCount":"0","resultStr":"{\"title\":\"Shape modelling reveals age-related knee bony shape changes in asymptomatic knees\",\"authors\":\"Katherine Nguyen, Diana M. Perriman, Jennie M. Scarvell, Mark R. Pickering, Catherine R. Galvin, Paul N. Smith, Joseph T. Lynch\",\"doi\":\"10.1002/jor.25923\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n <p>Osteoarthritis (OA) causes bony shape changes within the knee. Furthermore, the risk of developing OA increases with age. However, age alone does not cause OA. It is therefore important to understand the healthy age-related trajectories of knee shape before attributing these changes to OA. The aim of this study was to determine the association between bony knee shape and age using statistical-shape modelling (SSM). 96 participants received a CT scan of their knee. Three-dimensional models were created using manual segmentation. Separate SSM's for the distal femur and proximal tibia were created. Linear regression models were used to assess the association between age and femoral and tibial shape. Fourteen modes of the femoral and tibial SSM's captured 68% and 73% shape variation, respectively. Only femoral mode 3 and tibial mode 7 were associated with age. Increasing age was related to larger femoral bone volume and deepening of the femoral trochlear groove. Furthermore, increased age was associated with medial tibial plateau expansion. Aspects of bony femoral and tibial shape were significantly associated with aging, including femoral and tibial bone size, femoral trochlear groove, and medial tibial plateau area. Changes in knee morphology occur as a normal process of aging without osteoarthritis development. This may be a response to mechanical loading over time<i>.</i> Further research investigating the effect of these changes on loading in the knee may provide valuable information for knee health in older age.</p>\\n </section>\\n </div>\",\"PeriodicalId\":16650,\"journal\":{\"name\":\"Journal of Orthopaedic Research®\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.1000,\"publicationDate\":\"2024-06-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jor.25923\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Orthopaedic Research®\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/jor.25923\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"ORTHOPEDICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Orthopaedic Research®","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/jor.25923","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ORTHOPEDICS","Score":null,"Total":0}
引用次数: 0
摘要
骨关节炎(OA)会导致膝关节骨骼形状发生变化。此外,患 OA 的风险会随着年龄的增长而增加。然而,年龄本身并不会导致 OA。因此,在将这些变化归因于 OA 之前,了解膝关节形状与健康年龄相关的轨迹非常重要。本研究旨在利用统计形状建模(SSM)确定膝关节骨骼形状与年龄之间的关联。96 名参与者接受了膝关节 CT 扫描。通过手动分割创建了三维模型。分别创建了股骨远端和胫骨近端的 SSM。线性回归模型用于评估年龄与股骨和胫骨形状之间的关系。股骨和胫骨SSM的14种模式分别捕获了68%和73%的形状变化。只有股骨模式 3 和胫骨模式 7 与年龄有关。年龄的增长与股骨头体积增大和股骨蹄状沟加深有关。此外,年龄的增长还与胫骨内侧平台的扩张有关。股骨和胫骨骨性形状的各个方面都与年龄增长有显著关系,包括股骨和胫骨骨量、股骨蹄状沟和胫骨内侧平台面积。膝关节形态的变化是正常的衰老过程,不会发展成骨关节炎。这可能是对长期机械负荷的一种反应。进一步研究这些变化对膝关节负荷的影响,可能会为老年人的膝关节健康提供有价值的信息。
Osteoarthritis (OA) causes bony shape changes within the knee. Furthermore, the risk of developing OA increases with age. However, age alone does not cause OA. It is therefore important to understand the healthy age-related trajectories of knee shape before attributing these changes to OA. The aim of this study was to determine the association between bony knee shape and age using statistical-shape modelling (SSM). 96 participants received a CT scan of their knee. Three-dimensional models were created using manual segmentation. Separate SSM's for the distal femur and proximal tibia were created. Linear regression models were used to assess the association between age and femoral and tibial shape. Fourteen modes of the femoral and tibial SSM's captured 68% and 73% shape variation, respectively. Only femoral mode 3 and tibial mode 7 were associated with age. Increasing age was related to larger femoral bone volume and deepening of the femoral trochlear groove. Furthermore, increased age was associated with medial tibial plateau expansion. Aspects of bony femoral and tibial shape were significantly associated with aging, including femoral and tibial bone size, femoral trochlear groove, and medial tibial plateau area. Changes in knee morphology occur as a normal process of aging without osteoarthritis development. This may be a response to mechanical loading over time. Further research investigating the effect of these changes on loading in the knee may provide valuable information for knee health in older age.
期刊介绍:
The Journal of Orthopaedic Research is the forum for the rapid publication of high quality reports of new information on the full spectrum of orthopaedic research, including life sciences, engineering, translational, and clinical studies.