J. Kroesbergen, A.M.P. Van Steijn, W.J. Gelsema, C.L. De Ligny
{"title":"99mTc骨扫描剂- ii。99mTc(Sn)焦磷酸盐配合物在骨矿物相上的吸附","authors":"J. Kroesbergen, A.M.P. Van Steijn, W.J. Gelsema, C.L. De Ligny","doi":"10.1016/S0047-0740(86)80001-8","DOIUrl":null,"url":null,"abstract":"<div><p>The adsorption of pyrophosphate, tin-pyrophosphate and 99mTc(Sn)pyrophosphate on Ca<sub>3</sub>(PO<sub>4</sub>)<sub>2</sub> was investigated at pH 4.0 and pH 7.4. All components were radioactively labeled.</p><p>Tin and reduced technetium were in most cases almost completely bound. The adsorption of pyrophosphate, tin(II) and technetium-99m at pH 4.0 was higher than at pH 7.4. The presence of tin gave rise to an increase of the pyrophosphate adsorption that was much larger than can be accounted for by a stoichiometric adsorption of tin-pyrophosphate.</p><p>It is concluded that tin and technetium are bound as negatively charged complexes with pyrophosphate.</p><p>Finally it is argued that the fraction of the bone scanning agent that reaches the bone surface is adsorbed completely by the mineral phase.</p></div>","PeriodicalId":75939,"journal":{"name":"International journal of nuclear medicine and biology","volume":"12 6","pages":"Pages 411-417"},"PeriodicalIF":0.0000,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0047-0740(86)80001-8","citationCount":"4","resultStr":"{\"title\":\"99mTc bone scanning agents—II. Adsorption of 99mTc(Sn)pyrophosphate complexes on the mineral phase of bone\",\"authors\":\"J. Kroesbergen, A.M.P. Van Steijn, W.J. Gelsema, C.L. De Ligny\",\"doi\":\"10.1016/S0047-0740(86)80001-8\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The adsorption of pyrophosphate, tin-pyrophosphate and 99mTc(Sn)pyrophosphate on Ca<sub>3</sub>(PO<sub>4</sub>)<sub>2</sub> was investigated at pH 4.0 and pH 7.4. All components were radioactively labeled.</p><p>Tin and reduced technetium were in most cases almost completely bound. The adsorption of pyrophosphate, tin(II) and technetium-99m at pH 4.0 was higher than at pH 7.4. The presence of tin gave rise to an increase of the pyrophosphate adsorption that was much larger than can be accounted for by a stoichiometric adsorption of tin-pyrophosphate.</p><p>It is concluded that tin and technetium are bound as negatively charged complexes with pyrophosphate.</p><p>Finally it is argued that the fraction of the bone scanning agent that reaches the bone surface is adsorbed completely by the mineral phase.</p></div>\",\"PeriodicalId\":75939,\"journal\":{\"name\":\"International journal of nuclear medicine and biology\",\"volume\":\"12 6\",\"pages\":\"Pages 411-417\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1986-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/S0047-0740(86)80001-8\",\"citationCount\":\"4\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International journal of nuclear medicine and biology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0047074086800018\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International journal of nuclear medicine and biology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0047074086800018","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
99mTc bone scanning agents—II. Adsorption of 99mTc(Sn)pyrophosphate complexes on the mineral phase of bone
The adsorption of pyrophosphate, tin-pyrophosphate and 99mTc(Sn)pyrophosphate on Ca3(PO4)2 was investigated at pH 4.0 and pH 7.4. All components were radioactively labeled.
Tin and reduced technetium were in most cases almost completely bound. The adsorption of pyrophosphate, tin(II) and technetium-99m at pH 4.0 was higher than at pH 7.4. The presence of tin gave rise to an increase of the pyrophosphate adsorption that was much larger than can be accounted for by a stoichiometric adsorption of tin-pyrophosphate.
It is concluded that tin and technetium are bound as negatively charged complexes with pyrophosphate.
Finally it is argued that the fraction of the bone scanning agent that reaches the bone surface is adsorbed completely by the mineral phase.
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