{"title":"[实体恶性肿瘤相关静脉血栓栓塞症患者的临床特征和实验室指标分析]。","authors":"Yong-Mei Zhou, Hai-Ya Zhang, Qing-Qing Guo, Fang-Fang Lou, Xiang-Hong Zhou, Fei Ran","doi":"10.19746/j.cnki.issn.1009-2137.2024.03.030","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To analyze the clinical features and laboratory indicators in patients with solid malignant tumor-associated venous thromboembolism (Ta-VTE), and to study the risk factors for Ta-VTE.</p><p><strong>Methods: </strong>The hospitalized patients with VTE in Guizhou Provincial People's Hospital from January to December 2020 were enrolled, and they were divided into Ta-VTE group and pure VTE group based on the presence or absence of solid malignant tumor. The differences in clinical data and laboratory indicators between the two groups were analyzed, and the indicators with significant differences were included in logistic regression model to analyze the risk factors of Ta-VTE.</p><p><strong>Results: </strong>A total of 288 patients with VTE were included in this study, including 64 cases in Ta-VTE group and 224 cases in pure VTE group, respectively. There were significant differences in the following indexes between the two groups, including the hospitalization time (14.20±15.29 d <i>vs</i> 10.05±6.90 d, <i>t</i>=3.112, <i>P</i> =0.002), pain (35.94% <i>vs</i> 65.18%, <i>χ</i><sup>2</sup>=17.554, <i>P</i> =0.000), recent surgery (75.00% <i>vs</i> 37.50%, <i>χ</i><sup>2</sup>=28.196, <i>P</i> =0.000), D-dimer [2.8 (0.92, 7.55) μg/ml <i>vs</i> 5.69 (2.25, 13.91) μg/ml, <i>Z</i>=-2.710, <i>P</i> =0.007], PLR[198.59 (139.54, 312.16) <i>vs</i> 149.76 (114.08, 233.66), <i>Z</i>=-2.924, <i>P</i> =0.003] and TBIL[10.90 (7.63, 15.68) μmol/L <i>vs</i> 12.90 (9.33, 18.28) μmol/L, <i>Z</i>=-2.066, <i>P</i> =0.039]. There was no significant difference in the other indicators (<i>P</i> >0.05). The result of multivariate logistic regression analysis showed that elevated PLR (<i>OR</i> =1.003, 95%<i>CI</i> : 1.000-1.006, <i>P</i> =0.027), recent surgery (<i>OR</i> =4.312, 95%<i>CI</i> : 2.093-8.885, <i>P</i> =0.000) and prolonged hospitalization (<i>OR</i> =1.037, 95%<i>CI</i> : 1.002-1.074, <i>P</i> =0.038）were independent risk factors for Ta-VTE. However, pain (<i>OR</i> =0.274, 95%<i>CI</i> : 0.133-0.564, <i>P</i> =0.000) was a protective factor.</p><p><strong>Conclusion: </strong>Elevated PLR level, recent surgery and prolonged hospital stay are independent risk factors for Ta-VTE patients, and rational use of these indicators is helpful for the clinical diagnosis and treatment of Ta-VTE patients.</p>","PeriodicalId":35777,"journal":{"name":"中国实验血液学杂志","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[Analysis of Clinical Characteristics and Laboratory Indicators in Patients with Solid Malignant Tumor-Associated Venous Thromboembolism].\",\"authors\":\"Yong-Mei Zhou, Hai-Ya Zhang, Qing-Qing Guo, Fang-Fang Lou, Xiang-Hong Zhou, Fei Ran\",\"doi\":\"10.19746/j.cnki.issn.1009-2137.2024.03.030\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To analyze the clinical features and laboratory indicators in patients with solid malignant tumor-associated venous thromboembolism (Ta-VTE), and to study the risk factors for Ta-VTE.</p><p><strong>Methods: </strong>The hospitalized patients with VTE in Guizhou Provincial People's Hospital from January to December 2020 were enrolled, and they were divided into Ta-VTE group and pure VTE group based on the presence or absence of solid malignant tumor. The differences in clinical data and laboratory indicators between the two groups were analyzed, and the indicators with significant differences were included in logistic regression model to analyze the risk factors of Ta-VTE.</p><p><strong>Results: </strong>A total of 288 patients with VTE were included in this study, including 64 cases in Ta-VTE group and 224 cases in pure VTE group, respectively. There were significant differences in the following indexes between the two groups, including the hospitalization time (14.20±15.29 d <i>vs</i> 10.05±6.90 d, <i>t</i>=3.112, <i>P</i> =0.002), pain (35.94% <i>vs</i> 65.18%, <i>χ</i><sup>2</sup>=17.554, <i>P</i> =0.000), recent surgery (75.00% <i>vs</i> 37.50%, <i>χ</i><sup>2</sup>=28.196, <i>P</i> =0.000), D-dimer [2.8 (0.92, 7.55) μg/ml <i>vs</i> 5.69 (2.25, 13.91) μg/ml, <i>Z</i>=-2.710, <i>P</i> =0.007], PLR[198.59 (139.54, 312.16) <i>vs</i> 149.76 (114.08, 233.66), <i>Z</i>=-2.924, <i>P</i> =0.003] and TBIL[10.90 (7.63, 15.68) μmol/L <i>vs</i> 12.90 (9.33, 18.28) μmol/L, <i>Z</i>=-2.066, <i>P</i> =0.039]. There was no significant difference in the other indicators (<i>P</i> >0.05). The result of multivariate logistic regression analysis showed that elevated PLR (<i>OR</i> =1.003, 95%<i>CI</i> : 1.000-1.006, <i>P</i> =0.027), recent surgery (<i>OR</i> =4.312, 95%<i>CI</i> : 2.093-8.885, <i>P</i> =0.000) and prolonged hospitalization (<i>OR</i> =1.037, 95%<i>CI</i> : 1.002-1.074, <i>P</i> =0.038）were independent risk factors for Ta-VTE. However, pain (<i>OR</i> =0.274, 95%<i>CI</i> : 0.133-0.564, <i>P</i> =0.000) was a protective factor.</p><p><strong>Conclusion: </strong>Elevated PLR level, recent surgery and prolonged hospital stay are independent risk factors for Ta-VTE patients, and rational use of these indicators is helpful for the clinical diagnosis and treatment of Ta-VTE patients.</p>\",\"PeriodicalId\":35777,\"journal\":{\"name\":\"中国实验血液学杂志\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"中国实验血液学杂志\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.19746/j.cnki.issn.1009-2137.2024.03.030\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"中国实验血液学杂志","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.19746/j.cnki.issn.1009-2137.2024.03.030","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
摘要
目的分析实体瘤相关性静脉血栓栓塞症（Ta-VTE）患者的临床特征和实验室指标，研究Ta-VTE的危险因素：纳入贵州省人民医院2020年1月至12月住院的VTE患者，根据有无实体恶性肿瘤分为Ta-VTE组和单纯VTE组。分析两组患者临床资料和实验室指标的差异，并将差异显著的指标纳入Logistic回归模型，分析Ta-VTE的危险因素：本研究共纳入288例VTE患者，其中Ta-VTE组64例，单纯VTE组224例。两组患者住院时间（14.20±15.29 d vs 10.05±6.90 d，t=3.112，P=0.002）、疼痛（35.94% vs 65.18%，χ2=17.554，P=0.000）、近期手术（75.00% vs 37.50%，χ2=28.196，P =0.000）、D-二聚体[2.8（0.92，7.55）μg/ml vs 5.69（2.25，13.91）μg/ml，Z=-2.710，P =0.007]、PLR[198.59（139.54，312.16） vs 149.76 (114.08, 233.66), Z=-2.924, P =0.003]和 TBIL[10.90 (7.63, 15.68) μmol/L vs 12.90 (9.33, 18.28) μmol/L, Z=-2.066, P =0.039]。其他指标无明显差异（P>0.05）。多变量逻辑回归分析结果显示，PLR 升高（OR =1.003，95%CI：1.000-1.006，P =0.027）、近期手术（OR =4.312，95%CI：2.093-8.885，P =0.000）和长期住院（OR =1.037，95%CI：1.002-1.074，P =0.038）是 Ta-VTE 的独立危险因素。然而，疼痛（OR =0.274，95%CI : 0.133-0.564，P =0.000）是一个保护因素：结论：PLR水平升高、近期手术和住院时间延长是Ta-VTE患者的独立危险因素，合理使用这些指标有助于Ta-VTE患者的临床诊断和治疗。
[Analysis of Clinical Characteristics and Laboratory Indicators in Patients with Solid Malignant Tumor-Associated Venous Thromboembolism].
Objective: To analyze the clinical features and laboratory indicators in patients with solid malignant tumor-associated venous thromboembolism (Ta-VTE), and to study the risk factors for Ta-VTE.
Methods: The hospitalized patients with VTE in Guizhou Provincial People's Hospital from January to December 2020 were enrolled, and they were divided into Ta-VTE group and pure VTE group based on the presence or absence of solid malignant tumor. The differences in clinical data and laboratory indicators between the two groups were analyzed, and the indicators with significant differences were included in logistic regression model to analyze the risk factors of Ta-VTE.
Results: A total of 288 patients with VTE were included in this study, including 64 cases in Ta-VTE group and 224 cases in pure VTE group, respectively. There were significant differences in the following indexes between the two groups, including the hospitalization time (14.20±15.29 d vs 10.05±6.90 d, t=3.112, P =0.002), pain (35.94% vs 65.18%, χ2=17.554, P =0.000), recent surgery (75.00% vs 37.50%, χ2=28.196, P =0.000), D-dimer [2.8 (0.92, 7.55) μg/ml vs 5.69 (2.25, 13.91) μg/ml, Z=-2.710, P =0.007], PLR[198.59 (139.54, 312.16) vs 149.76 (114.08, 233.66), Z=-2.924, P =0.003] and TBIL[10.90 (7.63, 15.68) μmol/L vs 12.90 (9.33, 18.28) μmol/L, Z=-2.066, P =0.039]. There was no significant difference in the other indicators (P >0.05). The result of multivariate logistic regression analysis showed that elevated PLR (OR =1.003, 95%CI : 1.000-1.006, P =0.027), recent surgery (OR =4.312, 95%CI : 2.093-8.885, P =0.000) and prolonged hospitalization (OR =1.037, 95%CI : 1.002-1.074, P =0.038）were independent risk factors for Ta-VTE. However, pain (OR =0.274, 95%CI : 0.133-0.564, P =0.000) was a protective factor.
Conclusion: Elevated PLR level, recent surgery and prolonged hospital stay are independent risk factors for Ta-VTE patients, and rational use of these indicators is helpful for the clinical diagnosis and treatment of Ta-VTE patients.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
