Elizabeth Asige, Gillian Saloojee, Carin Andrews, Lukia H Namaganda, Angelina Kakooza-Mwesige, Diane L Damiano, Hans Forssberg
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引用次数: 0
摘要
目的:评估 Akwenda 干预计划对脑瘫(CP)儿童和青少年的运动、自理和社会功能的疗效:这是一项分组随机对照、单盲干预研究,研究对象为乌干达东部农村地区的 100 名脑瘫患者(2-23 岁;52 名男性)。一半人被分配到干预计划中,其余人作为候补对照。在分组前和干预后收集了粗大运动功能测量-66(GMFM-66)和乌干达版儿科残疾评估量表(PEDI-UG)。一般线性模型和 t 检验用于比较组内和组间的变化。Cohen's d 估计了组间差异的效应大小。按年龄和活动能力分组对变化分数进行评估:在GMFM-66(P =0.003)和PEDI-UG结果(P 0.8)中发现了显著的组间时间交互作用,PEDI-UG结果中除活动能力外均存在差异:Akwenda干预计划对不同年龄和活动能力水平的功能和活动产生了巨大的积极影响。
Functioning and activity outcomes of the Akwenda Intervention Program for children and young adults with cerebral palsy in Uganda: A cluster-randomized trial.
Aim: To evaluate the efficacy of the Akwenda Intervention Program on motor, self-care, and social function of children and young people with cerebral palsy (CP).
Method: This was a cluster-randomized, controlled, single-blinded, intervention study of 100 participants with CP (2-23 years; 52 males) in rural eastern Uganda. Half were allocated to the intervention program, the remainder served as waitlist controls. Gross Motor Function Measure-66 (GMFM-66) and the Ugandan version of Pediatric Evaluation of Disability Inventory (PEDI-UG) were collected before group allocation and after intervention. General linear models and t-tests were used to compare changes within and between groups. Cohen's d estimated the effect size of group differences. Change scores were evaluated by age and mobility subgroups.
Results: Significant group by time interactions were found for GMFM-66 (p =0.003) and PEDI-UG outcomes (p <0.001), except mobility, with the intervention group demonstrating greater changes. Both groups increased their scores on the GMFM-66 and child PEDI-UG, while only the intervention group had significant increases in caregiver assistance scores and across all age and mobility subgroups. Cohen's d showed large effect sizes (d >0.8) of differences for PEDI-UG outcomes except mobility.
Interpretation: The Akwenda Intervention Program had a large positive impact on functioning and activity across age and mobility levels.
期刊介绍:
Wiley-Blackwell is pleased to publish Developmental Medicine & Child Neurology (DMCN), a Mac Keith Press publication and official journal of the American Academy for Cerebral Palsy and Developmental Medicine (AACPDM) and the British Paediatric Neurology Association (BPNA).
For over 50 years, DMCN has defined the field of paediatric neurology and neurodisability and is one of the world’s leading journals in the whole field of paediatrics. DMCN disseminates a range of information worldwide to improve the lives of disabled children and their families. The high quality of published articles is maintained by expert review, including independent statistical assessment, before acceptance.