一碳代谢影响癌症中的 T 细胞免疫。

IF 11.4 1区 医学 Q1 ENDOCRINOLOGY & METABOLISM Trends in Endocrinology and Metabolism Pub Date : 2024-11-01 Epub Date: 2024-06-25 DOI:10.1016/j.tem.2024.05.010
Yajing Qiu, Ermei Xie, Haipeng Xu, Hongcheng Cheng, Guideng Li
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引用次数: 0

摘要

单碳代谢(1CM)包括叶酸代谢和蛋氨酸代谢,是细胞提供能量和产生重要信号分子(包括单碳分子)的重要机制。它的调节在维持癌细胞增殖和促进癌细胞转移方面起着重要作用;此外,最近的研究还揭示了它对 T 细胞介导的免疫疗法疗效的影响。在本综述中,我们整合了目前对 1CM 如何影响 T 细胞活化、分化和功能的见解。此外,我们还深入探讨了调节 T 细胞和肿瘤细胞中 1CM 的策略,以提高被收养转移 T 细胞的疗效,克服肿瘤微环境 (TME) 中的代谢挑战,并最大限度地提高 T 细胞介导的免疫疗法的效益。
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One-carbon metabolism shapes T cell immunity in cancer.

One-carbon metabolism (1CM), comprising folate metabolism and methionine metabolism, serves as an important mechanism for cellular energy provision and the production of vital signaling molecules, including single-carbon moieties. Its regulation is instrumental in sustaining the proliferation of cancer cells and facilitating metastasis; in addition, recent research has shed light on its impact on the efficacy of T cell-mediated immunotherapy. In this review, we consolidate current insights into how 1CM affects T cell activation, differentiation, and functionality. Furthermore, we delve into the strategies for modulating 1CM in both T cells and tumor cells to enhance the efficacy of adoptively transferred T cells, overcome metabolic challenges in the tumor microenvironment (TME), and maximize the benefits of T cell-mediated immunotherapy.

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来源期刊
Trends in Endocrinology and Metabolism
Trends in Endocrinology and Metabolism 医学-内分泌学与代谢
CiteScore
20.10
自引率
0.00%
发文量
98
审稿时长
82 days
期刊介绍: Trends in Endocrinology and Metabolism (TEM) stands as a premier Reviews journal in the realms of metabolism and endocrinology. Our commitment is reflected in the publication of refined, concise, and highly impactful articles that delve into cutting-edge topics, encompassing basic, translational, and clinical aspects. From state-of-the-art treatments for endocrine diseases to groundbreaking developments in molecular biology, TEM provides comprehensive coverage. Explore recent advancements in diabetes, endocrine diseases, obesity, neuroendocrinology, immunometabolism, molecular and cellular biology, and a myriad of other areas through our journal. TEM serves as an invaluable resource for researchers, clinicians, lecturers, teachers, and students. Each monthly issue is anchored by Reviews and Opinion articles, with Reviews meticulously chronicling recent and significant developments, often contributed by leading researchers in specific fields. Opinion articles foster debate and hypotheses. Our shorter pieces include Science & Society, shedding light on issues at the intersection of science, society, and policy; Spotlights, which focus on exciting recent developments in the literature, and single-point hypotheses as Forum articles. We wholeheartedly welcome and encourage responses to previously published TEM content in the form of Letters.
期刊最新文献
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