小鼠摄食行为和能量平衡的变化与体重增加的时间相关性。

IF 4.2 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM Obesity Pub Date : 2024-06-27 DOI:10.1002/oby.24052
Payam A. Fathi, Michelle B. Bales, Julio E. Ayala
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引用次数: 0

摘要

目的:肥胖的特点是体内平衡机制失调,导致能量正平衡;然而,这种失调何时发生尚不清楚。我们评估了改用致肥高脂饮食(HFD)的雌雄小鼠促进体重增加的行为改变的时间过程:雄性和雌性 C57BL/6J 小鼠被饲养在代谢室中,并分别在 4 周和 3 周内从饲料改为 60% 或 45% 的高脂饮食。连续测量食物摄入量、进食模式、能量消耗(EE)和体重。另一批雄性小鼠从饲料改为60%高纤维食物,并可使用带锁或不带锁的跑步轮:结果:将小鼠换成致肥胖饮食会在头两周内引起短暂的摄食过多,随后出现持续的热量摄食过多。EE会增加,但不足以抵消增加的热量摄入,从而导致持续的净正能量平衡。摄入过多与更频繁地进食热量较高的食物(饱腹感受损)有关,尤其是在光照周期。跑步轮运动通过提高饱腹感和增加EE来延缓喂食60%高饱和脂肪酸的雄性小鼠的体重增加。然而,运动对饱腹感的影响在两周后不再明显,这与体重增加同时发生:结论:暴露于致肥性膳食会使平衡调节机制持续约 2 周,但最终会失效,因此体重增加的特点是饱腹感和饱腹感受损。通过研究暴露于高氟膳食的最初约两周内饱食和饱腹感机制的变化,可以深入了解肥胖的病因。
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Time-dependent changes in feeding behavior and energy balance associated with weight gain in mice fed obesogenic diets

Objective

Obesity is characterized by dysregulated homeostatic mechanisms resulting in positive energy balance; however, when this dysregulation occurs is unknown. We assessed the time course of alterations to behaviors promoting weight gain in male and female mice switched to an obesogenic high-fat diet (HFD).

Methods

Male and female C57BL/6J mice were housed in metabolic chambers and were switched from chow to a 60% or 45% HFD for 4 and 3 weeks, respectively. Food intake, meal patterns, energy expenditure (EE), and body weight were continuously measured. A separate cohort of male mice was switched from chow to a 60% HFD and was given access to locked or unlocked running wheels.

Results

Switching mice to obesogenic diets promotes transient bouts of hyperphagia during the first 2 weeks followed by persistent caloric hyperphagia. EE increases but not sufficiently enough to offset increased caloric intake, resulting in a sustained net positive energy balance. Hyperphagia is associated with consumption of calorically larger meals (impaired satiation) more frequently (impaired satiety), particularly during the light cycle. Running wheel exercise delays weight gain in male mice fed a 60% HFD by enhancing satiation and increasing EE. However, exercise effects on satiation are no longer apparent after 2 weeks, coinciding with weight gain.

Conclusions

Exposure to obesogenic diets engages homeostatic regulatory mechanisms for ~2 weeks that ultimately fail, and consequent weight gain is characterized by impaired satiation and satiety. Insights into the etiology of obesity can be obtained by investigating changes to satiation and satiety mechanisms during the initial ~2 weeks of HFD exposure.

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来源期刊
Obesity
Obesity 医学-内分泌学与代谢
CiteScore
11.70
自引率
1.40%
发文量
261
审稿时长
2-4 weeks
期刊介绍: Obesity is the official journal of The Obesity Society and is the premier source of information for increasing knowledge, fostering translational research from basic to population science, and promoting better treatment for people with obesity. Obesity publishes important peer-reviewed research and cutting-edge reviews, commentaries, and public health and medical developments.
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