RNA 涂层促进种植体周围骨结合

IF 5.4 2区 医学 Q2 MATERIALS SCIENCE, BIOMATERIALS ACS Biomaterials Science & Engineering Pub Date : 2024-11-11 Epub Date: 2024-06-29 DOI:10.1021/acsbiomaterials.4c00133
Xiao Zhang, Yicheng Chen, Shanluo Zhou, Ya Liu, Simin Zhu, Xuelian Jia, Zihan Lu, Yufan Zhang, Wenhui Zhang, Zhou Ye, Bolei Cai, Liang Kong, Fuwei Liu
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引用次数: 0

摘要

除了传递和携带遗传信息,RNA 在纳米材料世界中还扮演着重要的非生物角色。RNA 是一种天然的多阴离子生物大分子,其作为成骨诱导剂通过与其他无机材料结合促进成骨的能力直到最近才被发现。然而,它是否能促进植入物的骨结合尚未见报道。在此,我们研究了含 RNA 涂层材料对种植体周围骨结合的影响。我们使用从大鼠肌肉组织中提取的总 RNA 作为成骨诱导剂,并使用透明质酸(HA)来维持其负电荷。体外研究表明,在模拟体液(SBF)中,这种材料能促进钙盐沉积。细胞学实验表明,与对照组相比,含 RNA 的涂层能诱导更多的细胞粘附和成骨分化。动物实验结果表明,含 RNA 涂层具有骨诱导和骨传导活性,有利于骨形成和骨结合。因此,含 RNA 涂层可用于钛种植体的表面改性,以促进骨结合。
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RNA Coating Promotes Peri-Implant Osseointegration.

In addition to transmitting and carrying genetic information, RNA plays an important abiotic role in the world of nanomaterials. RNA is a natural polyanionic biomacromolecule, and its ability to promote osteogenesis by binding with other inorganic materials as an osteogenic induction agent was discovered only recently. However, whether it can promote osseointegration on implants has not been reported. Here, we investigated the effect of the RNA-containing coating materials on peri-implant osseointegration. Total RNA extracted from rat muscle tissue was used as an osteogenic induction agent, and hyaluronic acid (HA) was used to maintain its negative charge. In simulated body fluids (SBF), in vitro studies demonstrated that the resulting material encouraged calcium salt deposition. Cytological experiments showed that the RNA-containing coating induced greater cell adhesion and osteogenic differentiation in comparison to the control. The results of animal experiments showed that the RNA-containing coating had osteoinductive and bone conduction activities, which are beneficial for bone formation and osseointegration. Therefore, the RNA-containing coatings are useful for the surface modification of titanium implants to promote osseointegration.

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来源期刊
ACS Biomaterials Science & Engineering
ACS Biomaterials Science & Engineering Materials Science-Biomaterials
CiteScore
10.30
自引率
3.40%
发文量
413
期刊介绍: ACS Biomaterials Science & Engineering is the leading journal in the field of biomaterials, serving as an international forum for publishing cutting-edge research and innovative ideas on a broad range of topics: Applications and Health – implantable tissues and devices, prosthesis, health risks, toxicology Bio-interactions and Bio-compatibility – material-biology interactions, chemical/morphological/structural communication, mechanobiology, signaling and biological responses, immuno-engineering, calcification, coatings, corrosion and degradation of biomaterials and devices, biophysical regulation of cell functions Characterization, Synthesis, and Modification – new biomaterials, bioinspired and biomimetic approaches to biomaterials, exploiting structural hierarchy and architectural control, combinatorial strategies for biomaterials discovery, genetic biomaterials design, synthetic biology, new composite systems, bionics, polymer synthesis Controlled Release and Delivery Systems – biomaterial-based drug and gene delivery, bio-responsive delivery of regulatory molecules, pharmaceutical engineering Healthcare Advances – clinical translation, regulatory issues, patient safety, emerging trends Imaging and Diagnostics – imaging agents and probes, theranostics, biosensors, monitoring Manufacturing and Technology – 3D printing, inks, organ-on-a-chip, bioreactor/perfusion systems, microdevices, BioMEMS, optics and electronics interfaces with biomaterials, systems integration Modeling and Informatics Tools – scaling methods to guide biomaterial design, predictive algorithms for structure-function, biomechanics, integrating bioinformatics with biomaterials discovery, metabolomics in the context of biomaterials Tissue Engineering and Regenerative Medicine – basic and applied studies, cell therapies, scaffolds, vascularization, bioartificial organs, transplantation and functionality, cellular agriculture
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