抗癌免疫中的昼夜节律:机制与治疗机会。

IF 26.9 1区 医学 Q1 IMMUNOLOGY Annual review of immunology Pub Date : 2024-06-01 DOI:10.1146/annurev-immunol-090122-050842
Robert Pick, Chen Wang, Qun Zeng, Zeynep Melis Gül, Christoph Scheiermann
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引用次数: 0

摘要

约 24 小时的昼夜节律已成为免疫系统的重要调节器。这些振荡对启动短期的先天性免疫反应很重要,但令人惊讶的是,对长期的适应性免疫反应也很重要。最近的数据表明,它们在小鼠和人类的抗肿瘤免疫中发挥着核心作用。在这篇综述中,我们将讨论有关昼夜节律抗肿瘤免疫反应及其潜在控制机制的不断发展的文献。我们进一步概述了昼夜节律治疗方案--同步免疫疗法--利用免疫的日时差异获得最佳疗效。我们的目的是为研究人员和临床医生提供一个概览,以便更好地了解昼夜节律免疫系统以及如何最好地利用它进行时间治疗干预。这些知识对于更好地了解免疫反应本身非常重要,并能彻底改变我们治疗癌症和其他一系列疾病的方法,最终改善临床实践。
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Circadian Rhythms in Anticancer Immunity: Mechanisms and Treatment Opportunities.

Circadian rhythms of approximately 24 h have emerged as important modulators of the immune system. These oscillations are important for mounting short-term, innate immune responses, but surprisingly also long-term, adaptive immune responses. Recent data indicate that they play a central role in antitumor immunity, in both mice and humans. In this review, we discuss the evolving literature on circadian antitumor immune responses and the underlying mechanisms that control them. We further provide an overview of circadian treatment regimens-chrono-immunotherapies-that harness time-of-day differences in immunity for optimal efficacy. Our aim is to provide an overview for researchers and clinicians alike, for a better understanding of the circadian immune system and how to best harness it for chronotherapeutic interventions. This knowledge is important for a better understanding of immune responses per se and could revolutionize the way we approach the treatment of cancer and a range of other diseases, ultimately improving clinical practice.

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来源期刊
Annual review of immunology
Annual review of immunology 医学-免疫学
CiteScore
57.20
自引率
0.70%
发文量
29
期刊介绍: The Annual Review of Immunology, in publication since 1983, focuses on basic immune mechanisms and molecular basis of immune diseases in humans. Topics include innate and adaptive immunity; immune cell development and differentiation; immune control of pathogens (viruses, bacteria, parasites) and cancer; and human immunodeficiency and autoimmune diseases. The current volume of this journal has been converted from gated to open access through Annual Reviews' Subscribe to Open program, with all articles published under a CC BY license.
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