黄芩苷和黄芩素的潜在治疗作用。

IF 1.9 Q3 CHEMISTRY, MEDICINAL Avicenna Journal of Phytomedicine Pub Date : 2024-01-01 DOI:10.22038/AJP.2023.22307
Kamyar Sabry, Zahra Jamshidi, Seyed Ahmad Emami, Amirhossein Sahebka
{"title":"黄芩苷和黄芩素的潜在治疗作用。","authors":"Kamyar Sabry, Zahra Jamshidi, Seyed Ahmad Emami, Amirhossein Sahebka","doi":"10.22038/AJP.2023.22307","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>Baicalin and baicalein are natural flavonoids reported for the first time from <i>Scutellaria baicalensis</i> Georgi. Recently, attention has been paid to these valuable flavonoids due to their promising effects. This paper aims to have a comprehensive review of their pharmacological effects.</p><p><strong>Materials and methods: </strong>An extensive search through scientific databases including Scopus, PubMed, and ISI Web of Science was established.</p><p><strong>Results: </strong>According to literature, these compounds have been mainly effective in the treatment of neurological and neurodegenerative diseases, hepatic and cardiovascular disorders, metabolic syndrome, and cancers through anti-inflammatory and antioxidant pathways. Induction of apoptosis and autophagy, and inhibition of migration and metastasis are the main mechanisms for their cytotoxic and antitumor activities. Decreasing inflammation, reducing oxidative stress, regulating the metabolism of lipids, and decreasing fibrosis, apoptosis, and steatosis are their main hepatoprotective mechanisms. Inhibiting the development of cardiac fibrosis and reducing inflammation, oxidative stress, and apoptosis are also the mechanisms suggested for cardioprotective activities. Decreasing the accumulation of inflammatory mediators and improving cognitive function and depressive-like behaviours are the main mechanisms for neurological and neurodegenerative activities.</p><p><strong>Conclusion: </strong>The findings suggest the therapeutic potential of baicalin and baicalein. However, complementary research in different <i>in vitro</i> and <i>in vivo</i> models to investigate their mechanisms of action as well as clinical trials to evaluate their efficacy and safety are suggested.</p>","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"14 1","pages":"23-49"},"PeriodicalIF":1.9000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11210699/pdf/","citationCount":"0","resultStr":"{\"title\":\"Potential therapeutic effects of baicalin and baicalein.\",\"authors\":\"Kamyar Sabry, Zahra Jamshidi, Seyed Ahmad Emami, Amirhossein Sahebka\",\"doi\":\"10.22038/AJP.2023.22307\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>Baicalin and baicalein are natural flavonoids reported for the first time from <i>Scutellaria baicalensis</i> Georgi. Recently, attention has been paid to these valuable flavonoids due to their promising effects. This paper aims to have a comprehensive review of their pharmacological effects.</p><p><strong>Materials and methods: </strong>An extensive search through scientific databases including Scopus, PubMed, and ISI Web of Science was established.</p><p><strong>Results: </strong>According to literature, these compounds have been mainly effective in the treatment of neurological and neurodegenerative diseases, hepatic and cardiovascular disorders, metabolic syndrome, and cancers through anti-inflammatory and antioxidant pathways. Induction of apoptosis and autophagy, and inhibition of migration and metastasis are the main mechanisms for their cytotoxic and antitumor activities. Decreasing inflammation, reducing oxidative stress, regulating the metabolism of lipids, and decreasing fibrosis, apoptosis, and steatosis are their main hepatoprotective mechanisms. Inhibiting the development of cardiac fibrosis and reducing inflammation, oxidative stress, and apoptosis are also the mechanisms suggested for cardioprotective activities. Decreasing the accumulation of inflammatory mediators and improving cognitive function and depressive-like behaviours are the main mechanisms for neurological and neurodegenerative activities.</p><p><strong>Conclusion: </strong>The findings suggest the therapeutic potential of baicalin and baicalein. However, complementary research in different <i>in vitro</i> and <i>in vivo</i> models to investigate their mechanisms of action as well as clinical trials to evaluate their efficacy and safety are suggested.</p>\",\"PeriodicalId\":8677,\"journal\":{\"name\":\"Avicenna Journal of Phytomedicine\",\"volume\":\"14 1\",\"pages\":\"23-49\"},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2024-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11210699/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Avicenna Journal of Phytomedicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.22038/AJP.2023.22307\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, MEDICINAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Avicenna Journal of Phytomedicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.22038/AJP.2023.22307","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
引用次数: 0

摘要

目的:黄芩苷和黄芩素是首次从黄芩(Scutellaria baicalensis Georgi)中发现的天然黄酮类化合物。最近,这些珍贵的黄酮类化合物因其良好的功效而受到关注。本文旨在对其药理作用进行全面综述:通过 Scopus、PubMed 和 ISI Web of Science 等科学数据库进行了广泛搜索:文献显示,这些化合物主要通过抗炎和抗氧化途径有效治疗神经和神经退行性疾病、肝脏和心血管疾病、代谢综合征和癌症。诱导细胞凋亡和自噬,以及抑制迁移和转移是其细胞毒性和抗肿瘤活性的主要机制。减轻炎症反应、减少氧化应激、调节脂质代谢、减少纤维化、细胞凋亡和脂肪变性是其主要的保肝机制。抑制心脏纤维化的发展,减少炎症、氧化应激和细胞凋亡也是其心脏保护作用的机制。减少炎症介质的积累、改善认知功能和抑郁样行为是神经和神经退行性活动的主要机制:研究结果表明黄芩苷和黄芩素具有治疗潜力。结论:研究结果表明黄芩苷和黄芩素具有治疗潜力,但建议在不同的体外和体内模型中进行补充研究,以探究其作用机制,并进行临床试验,以评估其疗效和安全性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Potential therapeutic effects of baicalin and baicalein.

Objective: Baicalin and baicalein are natural flavonoids reported for the first time from Scutellaria baicalensis Georgi. Recently, attention has been paid to these valuable flavonoids due to their promising effects. This paper aims to have a comprehensive review of their pharmacological effects.

Materials and methods: An extensive search through scientific databases including Scopus, PubMed, and ISI Web of Science was established.

Results: According to literature, these compounds have been mainly effective in the treatment of neurological and neurodegenerative diseases, hepatic and cardiovascular disorders, metabolic syndrome, and cancers through anti-inflammatory and antioxidant pathways. Induction of apoptosis and autophagy, and inhibition of migration and metastasis are the main mechanisms for their cytotoxic and antitumor activities. Decreasing inflammation, reducing oxidative stress, regulating the metabolism of lipids, and decreasing fibrosis, apoptosis, and steatosis are their main hepatoprotective mechanisms. Inhibiting the development of cardiac fibrosis and reducing inflammation, oxidative stress, and apoptosis are also the mechanisms suggested for cardioprotective activities. Decreasing the accumulation of inflammatory mediators and improving cognitive function and depressive-like behaviours are the main mechanisms for neurological and neurodegenerative activities.

Conclusion: The findings suggest the therapeutic potential of baicalin and baicalein. However, complementary research in different in vitro and in vivo models to investigate their mechanisms of action as well as clinical trials to evaluate their efficacy and safety are suggested.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Avicenna Journal of Phytomedicine
Avicenna Journal of Phytomedicine CHEMISTRY, MEDICINAL-
CiteScore
3.40
自引率
4.50%
发文量
17
审稿时长
6 weeks
期刊最新文献
Aloe vera supplementation improves cardiovascular risk factors in hemodialysis patients: A randomized, double-blind, placebo-controlled trial. An in vitro antiviral evaluation of punicalagin toward influenza A virus. Apigenin attenuates serum concentrations of TNF-a, interleukin 1b and interleukin 6 in lipopolysaccharide-stimulated rats. Comparison of effects of P-coumaric acid and coumarin on colorectal cancer cell line by inducing apoptosis and autophagy. Effect of pretreatment with Devil's Claw on locomotor activity, infarct volume, and neuronal density in focal cerebral ischemia in rats.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1