肿瘤血管生成和乳腺癌耐药性的研究进展。

IF 5.6 2区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL Cancer Biology & Medicine Pub Date : 2024-06-25 DOI:10.20892/j.issn.2095-3941.2023.0515
Jiancheng Mou, Chenhong Li, Qinghui Zheng, Xuli Meng, Hongchao Tang
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引用次数: 0

摘要

血管生成被认为是肿瘤发生的一个标志性病理生理过程。通过加剧肿瘤缺氧、降低肿瘤内有效药物浓度和免疫相关机制,肿瘤血管生成导致的血管畸形在乳腺癌治疗耐药性的形成过程中起着至关重要的作用。抗血管生成疗法可通过促进肿瘤血管正常化来抵消这些乳腺癌耐药因素。抗血管生成疗法与化疗、靶向治疗或免疫疗法相结合,已成为克服乳腺癌耐药性的一种很有前景的方法。本综述探讨了与血管生成相关的机制,以及乳腺癌中肿瘤血管生成、缺氧肿瘤微环境、药物分布和免疫机制之间的相互作用。此外,本综述还全面总结了特定的抗血管生成药物,以及评估乳腺癌耐药性逆转的相关研究。本综述讨论了这些干预措施的潜在机制,并强调了临床应用抗血管生成疗法克服乳腺癌耐药性的前景。
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Research progress in tumor angiogenesis and drug resistance in breast cancer.

Angiogenesis is considered a hallmark pathophysiological process in tumor development. Aberrant vasculature resulting from tumor angiogenesis plays a critical role in the development of resistance to breast cancer treatments, via exacerbation of tumor hypoxia, decreased effective drug concentrations within tumors, and immune-related mechanisms. Antiangiogenic therapy can counteract these breast cancer resistance factors by promoting tumor vascular normalization. The combination of antiangiogenic therapy with chemotherapy, targeted therapy, or immunotherapy has emerged as a promising approach for overcoming drug resistance in breast cancer. This review examines the mechanisms associated with angiogenesis and the interactions among tumor angiogenesis, the hypoxic tumor microenvironment, drug distribution, and immune mechanisms in breast cancer. Furthermore, this review provides a comprehensive summary of specific antiangiogenic drugs, and relevant studies assessing the reversal of drug resistance in breast cancer. The potential mechanisms underlying these interventions are discussed, and prospects for the clinical application of antiangiogenic therapy to overcome breast cancer treatment resistance are highlighted.

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来源期刊
Cancer Biology & Medicine
Cancer Biology & Medicine Medicine-Oncology
CiteScore
9.80
自引率
3.60%
发文量
1143
审稿时长
12 weeks
期刊介绍: Cancer Biology & Medicine (ISSN 2095-3941) is a peer-reviewed open-access journal of Chinese Anti-cancer Association (CACA), which is the leading professional society of oncology in China. The journal quarterly provides innovative and significant information on biological basis of cancer, cancer microenvironment, translational cancer research, and all aspects of clinical cancer research. The journal also publishes significant perspectives on indigenous cancer types in China.
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