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引用次数: 0
摘要
肌肉疏松症是一种常见的临床症状,尤其是在老年群体和慢性病患者中。癌症患者经常会出现肌肉疏松症,并逐渐丧失肌肉质量、力量和功能。癌症及其治疗(包括药物治疗、放射治疗和手术)之间复杂的相互作用,是导致肌肉疏松症发病和恶化的重要原因。癌症通过炎症过程、新陈代谢改变和荷尔蒙失衡诱发肌肉萎缩。此外,药物和放射治疗会对肌肉产生直接毒性作用,导致身体功能受损。食欲不振、营养不良和缺乏运动会进一步加剧癌症患者的肌肉萎缩。影像技术是诊断肌肉疏松症的基石。磁共振成像、计算机断层扫描和双能 X 射线吸收测量法可提供有关肌肉结构和质量的宝贵信息。虽然每种模式都有其优势和局限性,但磁共振成像可生成高分辨率图像,并提供有关肌肉功能的动态信息。尽管存在这些挑战,但解决肌肉疏松症问题对于优化治疗效果和提高癌症患者的生存率至关重要。本综述探讨了导致肿瘤患者肌肉疏松症的因素,强调了早期检测和综合管理策略的重要性。
Unveiling the Intricate Dance: How Cancer Orchestrates Muscle Wasting and Sarcopenia.
Sarcopenia is a prevalent and clinically significant condition, particularly among older age groups and those with chronic disease. Patients with cancer frequently suffer from sarcopenia and progressive loss of muscle mass, strength, and function. The complex interplay between cancer and its treatment, including medical therapy, radiotherapy, and surgery, significantly contributes to the onset and worsening of sarcopenia. Cancer induces muscle wasting through inflammatory processes, metabolic alterations, and hormonal imbalance. Moreover, medical and radiation therapies exert direct toxic effects on muscles, contributing to the impairment of physical function. Loss of appetite, malnutrition, and physical inactivity further exacerbate muscle wasting in cancer patients. Imaging techniques are the cornerstones for sarcopenia diagnosis. Magnetic resonance imaging, computed tomography, and dual-energy X-ray absorptiometry provide valuable insights into muscle structure and quality. Although each modality has advantages and limitations, magnetic resonance imaging produces high-resolution images and provides dynamic information about muscle function. Despite these challenges, addressing sarcopenia is essential for optimizing treatment outcomes and improving survival rates in patients with cancer. This review explored the factors contributing to sarcopenia in oncologic patients, emphasizing the importance of early detection and comprehensive management strategies.
期刊介绍:
IN VIVO is an international peer-reviewed journal designed to bring together original high quality works and reviews on experimental and clinical biomedical research within the frames of physiology, pathology and disease management.
The topics of IN VIVO include: 1. Experimental development and application of new diagnostic and therapeutic procedures; 2. Pharmacological and toxicological evaluation of new drugs, drug combinations and drug delivery systems; 3. Clinical trials; 4. Development and characterization of models of biomedical research; 5. Cancer diagnosis and treatment; 6. Immunotherapy and vaccines; 7. Radiotherapy, Imaging; 8. Tissue engineering, Regenerative medicine; 9. Carcinogenesis.