产前和产后高脂肪饮食对大脑代谢功能障碍和记忆损伤的易感性与性别有关。

IF 4.8 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Journal of Nutritional Biochemistry Pub Date : 2024-06-28 DOI:10.1016/j.jnutbio.2024.109675
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引用次数: 0

摘要

发育中的大脑对早期营养摄入的影响非常敏感。本研究探讨了母体高脂饮食(HFD)是否会导致未成熟和成年后代的葡萄糖代谢障碍、神经炎症和记忆障碍,以及断奶后饮食是否会以性别依赖的方式影响成年后代。雌性大鼠断奶后,在交配前、妊娠期和哺乳期喂食高脂饮食(脂肪含量为 55.9%)或普通饲料(脂肪含量为 10%)8 周。在出生后第 21 天(PND21),两组的雌雄后代被分成两个新的组,NCD 或 HFD 饲喂一直持续到 PND180。在PND21和PND180,通过qPCR检测脑糖代谢、炎症和阿尔茨海默病病理相关标记物。对成年后代的外周胰岛素抵抗参数、空间记忆能力和脑糖代谢(18F-FDG-PET扫描以及IDE和GLUT3的蛋白水平)进行了评估。我们还对 PND21 和成年后代进行了组织学分析。我们发现,在 PND21 期,母体高氟酸膳食影响了两性葡萄糖代谢标记物的转录水平。在成年后代中,断奶后高频分解膳食与母体高频分解膳食相结合会诱发外周和大脑代谢紊乱、记忆能力受损以及炎症、痴呆症风险标记物和神经元损失的升高,这一点在雄性后代中更为明显。我们的研究结果表明,母体高频分解膳食会影响婴幼儿大脑葡萄糖代谢。断奶后高频分解膳食会导致后代的大脑代谢功能障碍和记忆力减退,而这种影响与母体高频分解膳食共同作用时会加剧。
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Sex-dependent susceptibility to brain metabolic dysfunction and memory impairment in response to pre and postnatal high-fat diet

The developing brain is sensitive to the impacts of early-life nutritional intake. This study investigates whether maternal high fat diet (HFD) causes glucose metabolism impairment, neuroinflammation, and memory impairment in immature and adult offspring, and whether it may be affected by postweaning diets in a sex-dependent manner in adult offspring. After weaning, female rats were fed HFD (55.9% fat) or normal chow diet (NCD; 10% fat) for 8 weeks before mating, during pregnancy, and lactation. On postnatal day 21 (PND21), the male and female offspring of both groups were split into two new groups, and NCD or HFD feeding was maintained until PND180. On PND21 and PND180, brain glucose metabolism, inflammation, and Alzheimer's pathology-related markers were by qPCR. In adult offspring, peripheral insulin resistance parameters, spatial memory performance, and brain glucose metabolism (18F-FDG-PET scan and protein levels of IDE and GLUT3) were assessed. Histological analysis was also performed on PND21 and adult offspring. On PND21, we found that maternal HFD affected transcript levels of glucose metabolism markers in both sexes. In adult offspring, more profoundly in males, postweaning HFD in combination with maternal HFD induced peripheral and brain metabolic disturbances, impaired memory performance and elevated inflammation, dementia risk markers, and neuronal loss. Our results suggest that maternal HFD affects brain glucose metabolism in the early ages of both sexes. Postweaning HFD sex-dependently causes brain metabolic dysfunction and memory impairment in later-life offspring; effects that can be worsened in combination with maternal HFD.

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来源期刊
Journal of Nutritional Biochemistry
Journal of Nutritional Biochemistry 医学-生化与分子生物学
CiteScore
9.50
自引率
3.60%
发文量
237
审稿时长
68 days
期刊介绍: Devoted to advancements in nutritional sciences, The Journal of Nutritional Biochemistry presents experimental nutrition research as it relates to: biochemistry, molecular biology, toxicology, or physiology. Rigorous reviews by an international editorial board of distinguished scientists ensure publication of the most current and key research being conducted in nutrition at the cellular, animal and human level. In addition to its monthly features of critical reviews and research articles, The Journal of Nutritional Biochemistry also periodically publishes emerging issues, experimental methods, and other types of articles.
期刊最新文献
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