山羊(Capra aegagrus hircus)静脉注射和皮下注射纳布啡的药代动力学。

IF 1.5 4区 农林科学 Q3 PHARMACOLOGY & PHARMACY Journal of veterinary pharmacology and therapeutics Pub Date : 2024-06-27 DOI:10.1111/jvp.13463
Jessica D. Garcia, Joe S. Smith, David Minich, Makenna Hopson, Rebecca Rahn, Chiara Hampton, Meggan Graves, Geneviève Bussières, Pierre-Yves Mulon, Lisa S. Ebner, Sherry Cox
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引用次数: 0

摘要

本研究旨在评估家山羊静脉注射(IV)和皮下注射(SC)纳布啡的药代动力学(PK)。通过静脉注射和皮下注射两种途径给六只山羊注射盐酸纳布啡,剂量均为 0.8 毫克/千克,样本采集阶段之间至少有 10 天的冲洗期。在 36 小时内收集了 18 份血浆样本,并使用反相高效液相色谱法(HPLC)进行分析。血浆数据采用区室和非区室方法进行分析。静脉注射纳布啡后,消除半衰期、从时间 0 到无穷大的血浆浓度时间曲线下面积(AUC0 - ∞)、零时浓度(C0)和体内总清除率分别为 120.4 ± 39.1(min-1 ± SD)、17311.01 ± 7227.32(min-ng-mL-1 ± SD)、675.6 ± 337.13(ng-mL-1 ± SD)和 44.5 ± 13.8(mL-min-1-kg-1 ± SD)。纳布啡经皮下注射后,消除半衰期、血浆浓度时间曲线下从 0 到无穷大的面积(AUC0 - ∞)和最大血浆药物浓度分别为 129 ± 52.9(min-1 ± SD)、20826.5 ± 14376.2(min-ng-mL-1)和 368.03 ± 503.78(ng-mL-1)。经皮下注射途径计算的生物利用度为 138 ± 126(% ± SD)。纳布啡在山羊体内的特点是消除快、皮下生物利用度高,未来可能成为山羊的一种安全镇痛阿片类药物。
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Pharmacokinetics of nalbuphine administered intravenously and subcutaneously in goats (Capra aegagrus hircus)

The purpose of this study was to evaluate the pharmacokinetics (PK) of intravenously (IV) and subcutaneously (SC) administered nalbuphine in domestic goats. Nalbuphine hydrochloride was administered at 0.8 mg/kg for both IV and SC routes in six goats with a minimum of 10-day washout period between sample collection phases. Eighteen plasma samples were collected over a 36-hour period, analyzed using reverse phase high-performance liquid chromatography (HPLC). Plasma data were analyzed using compartmental and noncompartmental approaches. Following IV nalbuphine administration, elimination half-life, area under the plasma concentration time curve from time 0 to infinity (AUC0 − ∞), concentration at time zero (C0), and total body clearance were 120.4 ± 39.1 (min−1 ± SD), 17311.01 ± 7227.32 (min·ng·mL−1 ± SD), 675.6 ± 337.13 (ng·mL−1 ± SD), and 44.5 ± 13.8 (mL·min−1·kg−1 ± SD), respectively. After SC nalbuphine administration, elimination half-life, area under the plasma concentration time curve from time 0 to infinity (AUC0 − ∞), and maximum plasma drug concentration were 129 ± 52.9 (min−1 ± SD), 20826.5 ± 14376.2 (min·ng·mL−1), and 368.03 ± 503.78 (ng·mL−1). Calculated bioavailability for the SC route was 138 ± 126 (% ± SD). Nalbuphine in goats is characterized by rapid elimination and high subcutaneous bioavailability and may be a safe analgesic opioid option in goats in the future.

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来源期刊
CiteScore
3.10
自引率
15.40%
发文量
69
审稿时长
8-16 weeks
期刊介绍: The Journal of Veterinary Pharmacology and Therapeutics (JVPT) is an international journal devoted to the publication of scientific papers in the basic and clinical aspects of veterinary pharmacology and toxicology, whether the study is in vitro, in vivo, ex vivo or in silico. The Journal is a forum for recent scientific information and developments in the discipline of veterinary pharmacology, including toxicology and therapeutics. Studies that are entirely in vitro will not be considered within the scope of JVPT unless the study has direct relevance to the use of the drug (including toxicants and feed additives) in veterinary species, or that it can be clearly demonstrated that a similar outcome would be expected in vivo. These studies should consider approved or widely used veterinary drugs and/or drugs with broad applicability to veterinary species.
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