Min Sun, Guanchi Yan, Siming Sun, Xiaonan Li, Wei Sun, Yuehui Wang
{"title":"丙二醛和锌可能与糖尿病微血管并发症的严重程度有关：中国东北地区老年 2 型糖尿病患者的初步研究》。","authors":"Min Sun, Guanchi Yan, Siming Sun, Xiaonan Li, Wei Sun, Yuehui Wang","doi":"10.2147/CIA.S464615","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Serum trace elements and oxidative stress factors are related to diabetic microvascular complications. The study was to investigate the complex relationship between trace elements, oxidative stress factors, and the severity of microvascular complications of diabetes in older adults.</p><p><strong>Methods: </strong>The present study included patients with or without type 2 diabetes, and blood glucose, blood lipids, trace elements (iron, magnesium, zinc), oxidative stress factors (malondialdehyde (MDA), nitric oxide (NO), superoxide dismutase (SOD), and total antioxidant capacity (T-AOC)) were evaluated. Risk factors for the severity of diabetic microvascular complications in older adults with diabetes were also estimated.</p><p><strong>Results: </strong>There were statistically significant differences in fasting blood glucose (FBG), triglycerides (TG), low density lipoprotein (LDL), glycated hemoglobin (HbAlc), MDA, NO, SOD, T-AOC, magnesium, and zinc between the two groups (<i>P<0.05</i>). Iron (r<sub>Zinc</sub> = 0.147, r<sub>SOD</sub> = 0.180, r<sub>T-AOC</sub> = 0.193, <i>P < 0.05</i>) was positively correlated with zinc, SOD and T-AOC. Iron was negatively correlated with MDA (r<sub>MDA</sub> = -0.146, <i>P < 0.05</i>). Magnesium was positively correlated with SOD (r<sub>Magnesium</sub> = 0.147, <i>P < 0.05</i>). Zinc (r<sub>SOD</sub> = 0.616, r<sub>T-AOC</sub> = 0.575, <i>P < 0.01</i>) was positively correlated with SOD and T-AOC. Zinc (r<sub>MDA</sub> =-0.636, r<sub>NO</sub>=-0.616, <i>P<0.01</i>) was positively correlated with MDA and negatively correlated with NO. The course of disease (18.653, [5.726; 60.764], <i>P <0.01</i>), FBG (1.265, [1.059; 1.511], <i>P <0.05</i>), HbAlc (1.545, [1.431; 1.680], P <0.01), MDA (2.989, [1.900; 4.702], <i>P <0.01</i>) were risk factor for the severity of diabetic microvascular complications. Zinc (0.680, [0.503; 0.919], <i>P < 0.05</i>) and SOD (0.820, [0.698; 0.964], <i>P < 0.05</i>) were protective factors for the severity of diabetic microvascular complications.</p><p><strong>Conclusion: </strong>Serum trace elements are related to oxidative stress levels in older adults with type 2 diabetes. The more stable trace element in older adults with diabetes, the lower the oxidative stress and the fewer microvascular complications of diabetes.</p>","PeriodicalId":48841,"journal":{"name":"Clinical Interventions in Aging","volume":"19 ","pages":"1141-1151"},"PeriodicalIF":3.5000,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11214795/pdf/","citationCount":"0","resultStr":"{\"title\":\"Malondialdehyde and Zinc May Relate to Severity of Microvascular Complications in Diabetes: A Preliminary Study on Older Adults with Type 2 Diabetes Mellitus in Northeast China.\",\"authors\":\"Min Sun, Guanchi Yan, Siming Sun, Xiaonan Li, Wei Sun, Yuehui Wang\",\"doi\":\"10.2147/CIA.S464615\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Serum trace elements and oxidative stress factors are related to diabetic microvascular complications. The study was to investigate the complex relationship between trace elements, oxidative stress factors, and the severity of microvascular complications of diabetes in older adults.</p><p><strong>Methods: </strong>The present study included patients with or without type 2 diabetes, and blood glucose, blood lipids, trace elements (iron, magnesium, zinc), oxidative stress factors (malondialdehyde (MDA), nitric oxide (NO), superoxide dismutase (SOD), and total antioxidant capacity (T-AOC)) were evaluated. Risk factors for the severity of diabetic microvascular complications in older adults with diabetes were also estimated.</p><p><strong>Results: </strong>There were statistically significant differences in fasting blood glucose (FBG), triglycerides (TG), low density lipoprotein (LDL), glycated hemoglobin (HbAlc), MDA, NO, SOD, T-AOC, magnesium, and zinc between the two groups (<i>P<0.05</i>). Iron (r<sub>Zinc</sub> = 0.147, r<sub>SOD</sub> = 0.180, r<sub>T-AOC</sub> = 0.193, <i>P < 0.05</i>) was positively correlated with zinc, SOD and T-AOC. Iron was negatively correlated with MDA (r<sub>MDA</sub> = -0.146, <i>P < 0.05</i>). Magnesium was positively correlated with SOD (r<sub>Magnesium</sub> = 0.147, <i>P < 0.05</i>). Zinc (r<sub>SOD</sub> = 0.616, r<sub>T-AOC</sub> = 0.575, <i>P < 0.01</i>) was positively correlated with SOD and T-AOC. Zinc (r<sub>MDA</sub> =-0.636, r<sub>NO</sub>=-0.616, <i>P<0.01</i>) was positively correlated with MDA and negatively correlated with NO. The course of disease (18.653, [5.726; 60.764], <i>P <0.01</i>), FBG (1.265, [1.059; 1.511], <i>P <0.05</i>), HbAlc (1.545, [1.431; 1.680], P <0.01), MDA (2.989, [1.900; 4.702], <i>P <0.01</i>) were risk factor for the severity of diabetic microvascular complications. Zinc (0.680, [0.503; 0.919], <i>P < 0.05</i>) and SOD (0.820, [0.698; 0.964], <i>P < 0.05</i>) were protective factors for the severity of diabetic microvascular complications.</p><p><strong>Conclusion: </strong>Serum trace elements are related to oxidative stress levels in older adults with type 2 diabetes. The more stable trace element in older adults with diabetes, the lower the oxidative stress and the fewer microvascular complications of diabetes.</p>\",\"PeriodicalId\":48841,\"journal\":{\"name\":\"Clinical Interventions in Aging\",\"volume\":\"19 \",\"pages\":\"1141-1151\"},\"PeriodicalIF\":3.5000,\"publicationDate\":\"2024-06-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11214795/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical Interventions in Aging\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.2147/CIA.S464615\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"GERIATRICS & GERONTOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Interventions in Aging","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2147/CIA.S464615","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"GERIATRICS & GERONTOLOGY","Score":null,"Total":0}
Malondialdehyde and Zinc May Relate to Severity of Microvascular Complications in Diabetes: A Preliminary Study on Older Adults with Type 2 Diabetes Mellitus in Northeast China.
Background: Serum trace elements and oxidative stress factors are related to diabetic microvascular complications. The study was to investigate the complex relationship between trace elements, oxidative stress factors, and the severity of microvascular complications of diabetes in older adults.
Methods: The present study included patients with or without type 2 diabetes, and blood glucose, blood lipids, trace elements (iron, magnesium, zinc), oxidative stress factors (malondialdehyde (MDA), nitric oxide (NO), superoxide dismutase (SOD), and total antioxidant capacity (T-AOC)) were evaluated. Risk factors for the severity of diabetic microvascular complications in older adults with diabetes were also estimated.
Results: There were statistically significant differences in fasting blood glucose (FBG), triglycerides (TG), low density lipoprotein (LDL), glycated hemoglobin (HbAlc), MDA, NO, SOD, T-AOC, magnesium, and zinc between the two groups (P<0.05). Iron (rZinc = 0.147, rSOD = 0.180, rT-AOC = 0.193, P < 0.05) was positively correlated with zinc, SOD and T-AOC. Iron was negatively correlated with MDA (rMDA = -0.146, P < 0.05). Magnesium was positively correlated with SOD (rMagnesium = 0.147, P < 0.05). Zinc (rSOD = 0.616, rT-AOC = 0.575, P < 0.01) was positively correlated with SOD and T-AOC. Zinc (rMDA =-0.636, rNO=-0.616, P<0.01) was positively correlated with MDA and negatively correlated with NO. The course of disease (18.653, [5.726; 60.764], P <0.01), FBG (1.265, [1.059; 1.511], P <0.05), HbAlc (1.545, [1.431; 1.680], P <0.01), MDA (2.989, [1.900; 4.702], P <0.01) were risk factor for the severity of diabetic microvascular complications. Zinc (0.680, [0.503; 0.919], P < 0.05) and SOD (0.820, [0.698; 0.964], P < 0.05) were protective factors for the severity of diabetic microvascular complications.
Conclusion: Serum trace elements are related to oxidative stress levels in older adults with type 2 diabetes. The more stable trace element in older adults with diabetes, the lower the oxidative stress and the fewer microvascular complications of diabetes.
期刊介绍：
Clinical Interventions in Aging, is an online, peer reviewed, open access journal focusing on concise rapid reporting of original research and reviews in aging. Special attention will be given to papers reporting on actual or potential clinical applications leading to improved prevention or treatment of disease or a greater understanding of pathological processes that result from maladaptive changes in the body associated with aging. This journal is directed at a wide array of scientists, engineers, pharmacists, pharmacologists and clinical specialists wishing to maintain an up to date knowledge of this exciting and emerging field.
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