脂肪干细胞驱动肥胖症中的 T 细胞浸润。

IF 11.4 1区医学 Q1 ENDOCRINOLOGY & METABOLISM Trends in Endocrinology and Metabolism Pub Date : 2024-11-01 Epub Date: 2024-06-29 DOI:10.1016/j.tem.2024.06.013

Aneta Balcerczyk, Assia Eljaafari, Luciano Pirola

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引用次数: 0

摘要

肥胖通常与脂肪组织（AT）炎症和免疫细胞浸润有关。最近，Liao 等人在《细胞报告》（Cell Reports）上撰文，利用单细胞（sc）RNA 序列分析（RNA-seq）、移植研究、体外共培养和基因敲除小鼠研究了 T 细胞浸润脂肪组织的机制。他们强调了分泌 C-C motif 趋化因子配体 5（CCL5）的脂肪干细胞（ASCs）的关键作用，为潜在疗法提供了启示。

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Adipose stem cells drive T cell infiltration in obesity.

Obesity is often associated with adipose tissue (AT) inflammation and immune cell infiltration. Writing recently in Cell Reports, Liao et al. investigated the mechanisms of T cell infiltration of AT using single cell (sc)RNA-sequencing (RNA-seq), transplantation studies, in vitro co-cultures, and knock-out mice. They highlighted the crucial role of C-C motif chemokine ligand 5 (CCL5)-secreting adipose stem cells (ASCs), offering insights for potential therapies.

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来源期刊

Trends in Endocrinology and Metabolism 医学-内分泌学与代谢

CiteScore

20.10

自引率

0.00%

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审稿时长

82 days

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