心血管安全药理学评估的创新方法。

IF 1.3 4区 医学 Q4 PHARMACOLOGY & PHARMACY Journal of pharmacological and toxicological methods Pub Date : 2024-07-01 DOI:10.1016/j.vascn.2024.107533
Michael K. Pugsley , Brett R. Winters , Yevgeniya E. Koshman , Simon Authier , C. Michael Foley , Eric S. Hayes , Michael J. Curtis
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引用次数: 0

摘要

自 2004 年以来,《药理学和毒理学方法杂志》(JPTM)每年都会出版一期关于安全药理学(SP)方法的主题刊物,本期社论是该刊物的序言。在此,我们重点介绍在比利时布鲁塞尔举行的 2023 年安全药理学会(SPS)会议的内容。本次会议共收到 138 篇摘要,现刊于 JPTM 本卷。与往年一样,这些手稿反映了SPS的各个创新领域,包括搏出量、心输出量和全身血管阻力的硅学建模,比较药物诱导的人诱导多能干细胞衍生心肌细胞(hiPSC-CMs)促心律失常敏感性的计算方法、评估心电图中校正后的 J 峰值和 T 峰值-峰值参数作为潜在的促心律失常生物标志物的实用性,以及非临床浓度-QTc(C-QTc)建模的适用性,该建模是进行体内 QTc 研究得出的数据,是安全性药理学研究核心电池的组成部分。
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Innovative approaches to cardiovascular safety pharmacology assessment

This editorial prefaces the annual themed issue on safety pharmacology (SP) methods which has been published since 2004 in the Journal of Pharmacological and Toxicological Methods (JPTM). Here we highlight content derived from the 2023 Safety Pharmacology Society (SPS) meeting held in Brussels, Belgium. The meeting generated 138 abstracts, reproduced in the current volume of JPTM. As in prior years, the manuscripts reflect various areas of innovation in SP including in silico modeling of stroke volume, cardiac output and systemic vascular resistance, computational approaches that compare drug-induced proarrhythmic sensitivity of human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs), an evaluation of the utility of the corrected J-Tpeak and Tpeak-to-Tend parameters from the ECG as potential proarrhythmia biomarkers, and the applicability of nonclinical concentration-QTc (C-QTc) modeling of data derived from the conduct of the in vivo QTc study as a component of the core battery of safety pharmacology studies.

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来源期刊
Journal of pharmacological and toxicological methods
Journal of pharmacological and toxicological methods PHARMACOLOGY & PHARMACY-TOXICOLOGY
CiteScore
3.60
自引率
10.50%
发文量
56
审稿时长
26 days
期刊介绍: Journal of Pharmacological and Toxicological Methods publishes original articles on current methods of investigation used in pharmacology and toxicology. Pharmacology and toxicology are defined in the broadest sense, referring to actions of drugs and chemicals on all living systems. With its international editorial board and noted contributors, Journal of Pharmacological and Toxicological Methods is the leading journal devoted exclusively to experimental procedures used by pharmacologists and toxicologists.
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