微生物驱动的抗癌疗法:从天然产品向前迈进。

IF 4.5 Q1 MICROBIOLOGY mLife Pub Date : 2024-05-27 eCollection Date: 2024-06-01 DOI:10.1002/mlf2.12118
Yunxuan Guan, Di Wu, Hui Wang, Ning-Ning Liu
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引用次数: 0

摘要

人类微生物组被认为是一种新出现的致癌标志,越来越多的人认识到微生物组是癌症发生和发展的关键影响因素。操纵微生物组,利用天然产品振兴抗癌疗法,有望改善癌症预后。在此,我们总结了我们目前对人类微生物组驱动的影响癌症进展和抗癌疗法的分子机制的理解。我们强调了天然产物通过开发靶向治疗策略作为化疗和免疫疗法的辅助剂来预防和治疗癌症的潜在转化和临床意义。本综述还进一步讨论了未来利用微生物组调节进行癌症治疗研究的挑战和机遇。
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Microbiome-driven anticancer therapy: A step forward from natural products.

Human microbiomes, considered as a new emerging and enabling cancer hallmark, are increasingly recognized as critical effectors in cancer development and progression. Manipulation of microbiome revitalizing anticancer therapy from natural products shows promise toward improving cancer outcomes. Herein, we summarize our current understanding of the human microbiome-driven molecular mechanisms impacting cancer progression and anticancer therapy. We highlight the potential translational and clinical implications of natural products for cancer prevention and treatment by developing targeted therapeutic strategies as adjuvants for chemotherapy and immunotherapy against tumorigenesis. The challenges and opportunities for future investigations using modulation of the microbiome for cancer treatment are further discussed in this review.

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