噬菌体疗法--一种古老的治疗抗生素和耐多药细菌感染的潜在策略。

IF 2.1 4区 生物学 Q3 MICROBIOLOGY Brazilian Journal of Microbiology Pub Date : 2024-09-01 Epub Date: 2024-07-01 DOI:10.1007/s42770-024-01434-7
Rajal Dave, Debashis Banerjee
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引用次数: 0

摘要

抗菌素耐药性在全球范围内的普遍存在,再加上新型抗生素的匮乏,使得科学界重新开始关注新型替代疗法的发现,以应对这一威胁。因此,在当前的后抗生素时代,"噬菌体疗法 "已成为解决这一问题的最有前途的选择之一。噬菌体其实很早就被发现了,它在杀灭各种细菌病原体(包括临床上的抗药性病原体)方面显示出更大的潜力。利用噬菌体疗法治疗传染病的其他一些优势包括:这些微生物在自然界中的可获得性更广、对宿主具有特异性作用、对人体没有任何明显的副作用,而且通常还具有更广泛的抗菌潜力。近来,噬菌体疗法的潜力已在全球范围内的各种治疗、临床试验和感染模型中得到证实,甚至抗生素也完全无法奏效。为了应对 AMR 的全球威胁,世界卫生组织和联合国共同提出了 "一个健康 "方法,最近又将其扩展到了噬菌体疗法。许多制药公司最近也开始利用噬菌体来开发不同的配方,以满足医疗和其他行业的需要。它甚至与抗生素一起作为组合疗法,在治疗或控制各种严重的抗生素耐药性临床感染方面显示出巨大的效果。噬菌体的这种不断扩大的潜力为未来对抗全球不断上升的 AMR 威胁带来了巨大希望。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Bacteriophage therapy- a refurbished age-old potential strategy to treat antibiotic and multidrug resistant bacterial infections in future.

The worldwide prevalence of antimicrobial resistance coupled with the unavailability of newer antibiotics, has brought the sharp focus back among the scientific community, towards the discovery of novel alternative therapeutics to tackle the menace. Consequently, in the current post-antibiotic era, 'Bacteriophage Therapy' has emerged as one of the most promising option to address this problem. Bacteriophages, actually discovered long back, has shown greater potential to kill various bacterial pathogens, including the resistant clinical ones. Some of the other advantages for the use of bacteriophage therapy to treat infectious diseases include, wider availability of these microorganisms in nature, host-specific action, absence of any significant side-effects in humans and most often also exhibiting a broader anti-bacterial potential. In the recent times, the potential of phage therapy has been demonstrated in various treatments, clinical trials and infection models across the globe, where even antibiotics have completely failed. To address the global threat of AMR, WHO and UN have jointly illustrated "One Health" approach, recently extending the context to bacteriophage therapy. Many pharmaceutical companies have also recently started employing bacteriophages for developing different kinds of formulations for catering to medical and other industries. It has even shown great effect as combinatorial therapy along with antibiotics, to treat or manage various critical antibiotic resistant clinical infections. This continuously expanding potential of the bacteriophages holds great promise in the future, in the fight against the rising threat of AMR globally.

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来源期刊
Brazilian Journal of Microbiology
Brazilian Journal of Microbiology 生物-微生物学
CiteScore
4.10
自引率
4.50%
发文量
216
审稿时长
1.0 months
期刊介绍: The Brazilian Journal of Microbiology is an international peer reviewed journal that covers a wide-range of research on fundamental and applied aspects of microbiology. The journal considers for publication original research articles, short communications, reviews, and letters to the editor, that may be submitted to the following sections: Biotechnology and Industrial Microbiology, Food Microbiology, Bacterial and Fungal Pathogenesis, Clinical Microbiology, Environmental Microbiology, Veterinary Microbiology, Fungal and Bacterial Physiology, Bacterial, Fungal and Virus Molecular Biology, Education in Microbiology. For more details on each section, please check out the instructions for authors. The journal is the official publication of the Brazilian Society of Microbiology and currently publishes 4 issues per year.
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