黑色素细胞的异常代谢参与了晕痣中树突状细胞的激活。

IF 4.5 3区 医学 Q2 IMMUNOLOGY Clinical immunology Pub Date : 2024-06-29 DOI:10.1016/j.clim.2024.110300
Ling Jiang , Yibo Hu , Yushan Zhang , Yuanyuan Zhao , Lijuan Gao , Yumeng Dong , Yixuan Liang , Haoran Guo , Songjiang Wu , Yuanmin Zhang , Jing Chen , Qinghai Zeng
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引用次数: 0

摘要

为了更好地了解晕痣的发展过程,我们对空间转录组学进行了全面分析。我们发现,晕痣的特点是过度活跃的免疫反应,由趋化因子和树突状细胞(DC)、T 细胞和巨噬细胞引发。因此,我们在晕痣中观察到细胞异常死亡,如凋亡和二硫化钼,其中一些与免疫密切相关。有趣的是,我们在晕痣中发现了尿苷二磷酸葡萄糖(UDP-G)等异常代谢物。伴随着直流电和 T 细胞的浸润,UDP-G 与某些形式的细胞死亡相关。随后的实验证实,UDP-G 在白癜风血清中增加,并能激活 DCs。我们还证实,氧化反应是 UDP-G 的诱导剂。总之,晕痣的免疫反应(包括 DC 激活)伴随着异常的细胞死亡和代谢产物。尤其是黑色素细胞衍生的UDP-G可能在DC活化过程中起着至关重要的作用。
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Abnormal metabolism in melanocytes participates in the activation of dendritic cell in halo nevus

A comprehensive analysis of spatial transcriptomics was carried out to better understand the progress of halo nevus. We found that halo nevus was characterized by overactive immune responses, triggered by chemokines and dendritic cells (DCs), T cells, and macrophages. Consequently, we observed abnormal cell death, such as apoptosis and disulfidptosis in halo nevus, some were closely related to immunity. Interestingly, we identified aberrant metabolites such as uridine diphosphate glucose (UDP-G) within the halo nevus. UDP-G, accompanied by the infiltration of DCs and T cells, exhibited correlations with certain forms of cell death. Subsequent experiments confirmed that UDP-G was increased in vitiligo serum and could activate DCs. We also confirmed that oxidative response is an inducer of UDP-G. In summary, the immune response in halo nevus, including DC activation, was accompanied by abnormal cell death and metabolites. Especially, melanocyte-derived UDP-G may play a crucial role in DC activation.

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来源期刊
Clinical immunology
Clinical immunology 医学-免疫学
CiteScore
12.30
自引率
1.20%
发文量
212
审稿时长
34 days
期刊介绍: Clinical Immunology publishes original research delving into the molecular and cellular foundations of immunological diseases. Additionally, the journal includes reviews covering timely subjects in basic immunology, along with case reports and letters to the editor.
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