COVID-19 患者的细胞因子特征和免疫失调:转录组和血清分析

IF 1.9 4区 医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Journal of Interferon and Cytokine Research Pub Date : 2024-08-01 Epub Date: 2024-07-01 DOI:10.1089/jir.2024.0083
Nikola Ralchev, Silviya Lyubenova Bradyanova, Yana Valerieva Doneva, Nikolina Mihaylova, Elena Vikentieva Elefterova-Florova, Andrey Ivanov Tchorbanov, José Francisco Muñoz-Valle, Maria Cristina Petralia, Ferdinando Nicoletti, Paolo Fagone
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引用次数: 0

摘要

由 SARS-CoV-2 病毒引起的 COVID-19 已造成全球健康危机,因此有必要加深对其病理生理学的了解。在本研究中,我们探讨了 COVID-19 患者的免疫和血液动态,以深入了解疾病的严重程度和预后。我们的研究结果显示,中度和重度病例的细胞因子谱各不相同。在中度病例的外周血单核细胞中,IL12A明显上调,这表明它在启动有效的免疫反应中起着潜在的作用。相反,重症病例的主要促炎细胞因子(IL23A、TNFalpha、IL1B 和 IFNG)下调,同时免疫抑制因子 IL10 上调,表明免疫环境失调。血清分析表明,在中度和重度病例中,IL6 和 IL10 水平都有所升高,这说明它们有可能成为疾病严重程度的标志物。值得注意的是,恢复期病例和致死病例的血清细胞因子没有明显差异。在 COVID-19 的致死病例中,D-二聚体、尿素和肌酐的升高与 IL6 和 IL10 相关。这项研究为目前了解和管理作为 COVID-19 病理学基础的失调免疫反应提供了宝贵的信息。
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Cytokine Signatures and Immune Dysregulation in COVID-19 Patients: Transcriptomic and Serum Analysis.

COVID-19, caused by the SARS-CoV-2 virus, has caused a global health crisis, necessitating a deeper understanding of its pathophysiology. In this study, we explored the immune and hematological dynamics in COVID-19 patients to gain insights into disease severity and prognosis. Our findings revealed distinct cytokine profiles in moderate and severe cases. IL12A was significantly upregulated in peripheral blood mononuclear cells from moderate cases, suggesting a potential role in initiating an effective immune response. Conversely, severe cases exhibited downregulation of key pro-inflammatory cytokines (IL23A, TNFalpha, IL1B, and IFNG) alongside an upregulation of the immunosuppressive IL10, indicative of a dysregulated immune environment. Serum analysis showed elevated IL6 and IL10 levels in both moderate and severe cases, emphasizing their potential as markers for disease severity. Notably, no significant differences in serum cytokines were found between recovery and lethal cases. In lethal cases of COVID-19, elevated D-dimer, urea, and creatinine correlated with IL6 and IL10. This study contributes valuable information to the ongoing efforts to understand and manage the dysregulated immune responses underlying COVID-19 pathology.

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来源期刊
CiteScore
3.80
自引率
0.00%
发文量
78
审稿时长
2.2 months
期刊介绍: Journal of Interferon & Cytokine Research (JICR) provides the latest groundbreaking research on all aspects of IFNs and cytokines. The Journal delivers current findings on emerging topics in this niche community, including the role of IFNs in the therapy of diseases such as multiple sclerosis, the understanding of the third class of IFNs, and the identification and function of IFN-inducible genes.
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