一项为期四年的回顾性研究:XEN45 对青光眼患者的临床疗效。

IF 2 4区 医学 Q2 OPHTHALMOLOGY Ophthalmic Research Pub Date : 2024-01-01 Epub Date: 2024-07-17 DOI:10.1159/000539504
María Pilar Bambó, Álvaro Tello, María José Vicente, Víctor Mallén, Andrés Biescas-Merino, Jacobo Yáñez, Carlos Isanta, Blanca Ferrández, Enrique Fuentemilla, Susana Pérez-Oliván, Noemí Güerri, José Manuel Larrosa, Vicente Polo, Luis Emilio Pablo
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引用次数: 0

摘要

引言评估 XEN45 人工晶体植入术对青光眼患者的长期有效性和安全性:方法:对2016年11月至2021年10月期间接受XEN45植入手术(单独或与白内障手术联合)的连续患者进行回顾性单中心研究。主要终点是平均眼压从术前值降低的情况:在筛选出的 230 名患者中,有 206 只眼睛(176 名患者)被纳入其中。53只眼睛(25.7%)单独接受了XEN手术,153只眼睛(74.3%)接受了联合手术(XEN+超声乳化)。单用 XEN 组的术前平均眼压(22.2±5.9 mmHg)明显高于 XEN+Phaco 组(19.8±4.5 mmHg)(P=0.0035)。在整个研究人群中,术前平均眼压从 20.5±5.0 mmHg 显著降至第 4 年的 15.8±4.4,p<0.0001。XEN-alone 组和 XEN+Phaco 组的术前平均眼压(95% CI)分别从 22.2(20.6 至 23.8)mmHg 和 19.8(19.1 至 20.6)mmHg 显著降至第 4 年的 15.6(12.2 至 16.9)mmHg 和 15.9(15.2 至 16.5)mmHg(p<0.0001)。降眼压药物的数量从 2.6±1.0 种显著减少到 1.3±1.3 种,XEN-alone 组和 XEN+Phaco 组之间无显著差异(p=0.1671)。术后第一天,62 只眼睛(30.1%)出现了某种并发症。15只眼睛(7.3%)接受了针刺手术:结论:无论是单独使用还是与超声乳化联合使用,XEN45 都能显著降低眼压,并减少长期使用降眼压药物的需求。
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A 4-Year Retrospective Study: Clinical Outcomes of XEN45 in Patients with Glaucoma.

Introduction: The main purpose of the current study was to evaluate the long-term effectiveness and safety of XEN45 implant, either alone or in combination with cataract surgery, in patients with glaucoma.

Methods: Retrospective and single center study conducted on consecutive patients who underwent a XEN45 implant, either alone or in combination with cataract surgery, between November 2016 and October 2021. The primary endpoint was the mean intraocular pressure (IOP) lowering from preoperative values.

Results: Among the 230 screened patients, 206 eyes (176 patients) were included. Fifty-three (25.7%) eyes had undergone XEN alone and 153 (74.3%) eyes had undergone a combined procedure (XEN+phacoemulsification). The mean preoperative IOP was significantly higher in the XEN-alone (22.2 ± 5.9 mm Hg) than in the XEN+Phaco (19.8 ± 4.5 mm Hg) group (p = 0.0035). In the overall study population, the mean preoperative IOP was significantly lowered from 20.5 ± 5.0 mm Hg to 15.8 ± 4.4 at year-4, p < 0.0001. The mean preoperative (95% confidence interval) IOP was significantly lowered from 22.2 (20.6-23.8) mm Hg and 19.8 (19.1-20.6) mm Hg to 15.6 (12.2-16.9) mm Hg and 15.9 (15.2-16.5) mm Hg at year-4 in the XEN-alone and XEN+Phaco groups, respectively (p < 0.0001 each, respectively). The number of ocular hypotensive medications was significant reduced from 2.6 ± 1.0 drugs to 1.3 ± 1.3 drugs, with no significant differences between XEN-alone and XEN+Phaco groups (p = 0.1671). On the first postoperative day, 62 (30.1%) eyes presented some type of complication. Fifteen (7.3%) eyes underwent a needling procedure.

Conclusion: XEN45, either alone or in combination with phacoemulsification, significantly lowered the IOP and reduced the need of ocular hypotensive medication in the long-term.

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来源期刊
Ophthalmic Research
Ophthalmic Research 医学-眼科学
CiteScore
3.80
自引率
4.80%
发文量
75
审稿时长
6-12 weeks
期刊介绍: ''Ophthalmic Research'' features original papers and reviews reporting on translational and clinical studies. Authors from throughout the world cover research topics on every field in connection with physical, physiologic, pharmacological, biochemical and molecular biological aspects of ophthalmology. This journal also aims to provide a record of international clinical research for both researchers and clinicians in ophthalmology. Finally, the transfer of information from fundamental research to clinical research and clinical practice is particularly welcome.
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